Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

11,351–11,400 of 18,558 reactions from Rhea

a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1alpha + CMP + H(+)
Direction not assertedBalance undeterminableRhea 57652
a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1balpha + CMP + H(+)
Direction not assertedBalance undeterminableRhea 57656
(+)-valencene + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = (+)-nootkatone + 2 oxidized [NADPH--hemoprotein reductase] + 3 H2O + 2 H(+)
Direction not assertedBalance undeterminableRhea 57660
(+)-valencene + reduced [NADPH--hemoprotein reductase] + O2 = alpha-nootkatol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not assertedBalance undeterminableRhea 57664
alpha-nootkatol + reduced [NADPH--hemoprotein reductase] + O2 = (+)-nootkatone + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)
Direction not assertedBalance undeterminableRhea 57668
(+)-5-epi-aristolochene + reduced [NADPH--hemoprotein reductase] + O2 = 2beta-hydroxy-5-epi-aristolochene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

? Direction not asserted

Balance undeterminable

Rhea 57672

4-epi-eremophilene + reduced [NADPH--hemoprotein reductase] + O2 = 4-epi-eremophilene-2beta-ol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 57676

a flavanone + reduced [NADPH--hemoprotein reductase] + O2 = a flavone + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 57680

4-hydroxyestrone + NH4(+) + O2 = pyridinestrone carboxylate + 2 H2O + 2 H(+)

Direction not assertedBalancedRhea 57684

cob(II)inamide + apo-[corrinoid adenosyltransferase] = cob(II)inamide-[corrinoid adenosyltransferase]

Direction not assertedBalance undeterminableRhea 57688

2 cob(II)inamide-[corrinoid adenosyltransferase] + reduced [electron-transfer flavoprotein] = 2 cob(I)inamide-[corrinoid adenosyltransferase] + oxidized [electron-transfer flavoprotein] + 3 H(+)

Direction not assertedBalance undeterminableRhea 57692

cob(I)inamide-[corrinoid adenosyltransferase] + ATP = apo-[corrinoid adenosyltransferase] + adenosylcob(III)inamide + triphosphate

Direction not assertedBalance undeterminableRhea 57696

a 2-demethylmenaquinone + reduced [flavodoxin] + 2 S-adenosyl-L-methionine = a 2-demethyl-8-methylmenaquinone + oxidized [flavodoxin] + 5'-deoxyadenosine + L-methionine + S-adenosyl-L-homocysteine + 3 H(+)

Direction not assertedBalance undeterminableRhea 57700

(2R)-3-(3,4-dihydroxyphenyl)lactate + NADP(+) = 3-(3,4-dihydroxyphenyl)pyruvate + NADPH + H(+)

Direction not assertedBalancedRhea 57704

(E)-coniferaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-(E)-coniferyl aldehyde + UDP + H(+)

Direction not assertedBalancedRhea 57708

(E)-sinapaldehyde + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-4-trans-sinapoyl aldehyde + UDP + H(+)

Direction not assertedBalancedRhea 57712

hydrogencarbonate + NH4(+) = carbamate + H2O + H(+)

Direction not assertedBalancedRhea 57716

ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)

Right to leftBalancedTransportRhea 57720

oxaloacetate + 2 Na(+)(in) + H(+) = pyruvate + 2 Na(+)(out) + CO2

Direction not assertedBalancedTransportRhea 57724

trans-aconitate + H(+) = itaconate + CO2

Direction not assertedBalancedRhea 57728

all-trans-7,8-dihydroretinol + A = all-trans-retinol + AH2

Direction not assertedBalancedRhea 57732

all-trans-3,4-didehydro-13,14-dihydroretinol + A = all-trans-3,4-didehydroretinol + AH2

Direction not assertedBalancedRhea 57736

a 2,3-saturated meromycolyl-[ACP] + NAD(+) = a trans-Delta(2)-meromycolyl-[ACP] + NADH + H(+)

Direction not assertedBalance undeterminableRhea 57740

phylloquinol + [protein]-disulfide = phylloquinone + [protein]-dithiol

Right to leftBalance undeterminableRhea 57744

icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)-methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H(+) = C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 NADP(+) + 5 CoA + 2 H2O

Direction not assertedBalance undeterminableRhea 57748

docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)-methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H(+) = C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 NADP(+) + 5 CoA + 2 H2O

Direction not assertedBalance undeterminableRhea 57752

17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)-methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H(+) = C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 NADP(+) + 5 CoA + 2 H2O

Direction not assertedBalance undeterminableRhea 57756

19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)-methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H(+) = C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 NADP(+) + 5 CoA + 2 H2O

Direction not assertedBalance undeterminableRhea 57760

2,6-dinitrotoluene + NADH + O2 = 3-methyl-4-nitrocatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57764

2-nitrotoluene + NADH + O2 = 3-methylcatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57768

3-nitrotoluene + NADH + O2 = 4-methylcatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57772

2-chloro-6-nitrotoluene + NADH + O2 = 4-chloro-3-methylcatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57776

2-chloro-4-nitrotoluene + NADH + O2 = 3-chloro-4-methylcatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57780

1,4-dinitrobenzene + NADH + O2 = 4-nitrocatechol + nitrite + NAD(+) + H(+)

Direction not assertedBalancedRhea 57784

1,3-dinitrobenzene + NADH + O2 = 4-nitrocatechol + nitrite + NAD(+) + H(+)

Direction not assertedBalancedRhea 57788

3,4-dinitrotoluene + NADH + O2 = 4-methyl-6-nitrocatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57792

4-nitrotoluene + NADH + O2 = 4-methylcatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57796

2,3-dinitrotoluene + NADH + O2 = 4-methyl-3-nitrocatechol + nitrite + NAD(+) + H(+)

Direction not assertedBalancedRhea 57800

1-chloro-3-nitrobenzene + NADH + O2 = 4-chlorocatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57804

1-chloro-3-nitrobenzene + NADH + O2 = 3-chlorocatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57808

1-chloro-2-nitrobenzene + NADH + O2 = 3-chlorocatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57812

dGMP + H2O = 2-deoxy-D-ribose 5-phosphate + guanine

Direction not assertedBalancedRhea 57816

[phosphate](n) + ADP = [phosphate](n+1) + AMP

Direction not assertedBalance undeterminableRhea 57820

dAMP + H2O = 2-deoxy-D-ribose 5-phosphate + adenine

Direction not assertedBalancedRhea 57824

dIMP + H2O = 2-deoxy-D-ribose 5-phosphate + hypoxanthine

Direction not assertedBalancedRhea 57828

5-oxopentanoate + NADP(+) + H2O = glutarate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 57832

thermospermine + O2 + H2O = 3-aminopropanal + spermidine + H2O2

Direction not assertedBalancedRhea 57836

1D-myo-inositol 1,3-bisphosphate + H2O = 1D-myo-inositol 1-phosphate + phosphate

Direction not assertedBalancedRhea 57840

fraxetin + reduced [NADPH--hemoprotein reductase] + O2 = sideretin (reduced form) + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 57844

scopoletin + 2-oxoglutarate + O2 = fraxetin + succinate + CO2

Direction not assertedBalancedRhea 57848

Page 228 of 372