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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
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Reference

Evidence

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Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

11,151–11,200 of 18,558 reactions from Rhea

5-amino-2-hydroxybenzoate + O2 = (2Z,4E)-4-amino-6-oxohepta-2,4-dienedioate + H(+)
Direction not assertedBalancedRhea 56840
nocamycin E + S-adenosyl-L-methionine = nocamycin I + S-adenosyl-L-homocysteine
Direction not assertedBalancedRhea 56844
1,6-didemethyltoxoflavin + S-adenosyl-L-methionine = reumycin + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 56848
reumycin + S-adenosyl-L-methionine = toxoflavin + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 56852
an aldehyde + A + H2O = a carboxylate + AH2 + H(+)
Direction not assertedBalance undeterminableRhea 56856
a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate = a 2-oxo-3-(phosphooxy)propyl medium-chain 3-oxoalkanoate + holo-[ACP]
Direction not assertedBalance undeterminableRhea 56860

6 malonyl-CoA + NADH + 5 NADPH + 12 H(+) = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + NAD(+) + 5 NADP(+) + 6 CoA + 4 H2O

Direction not assertedBalancedRhea 56864

(2R)-2-O-[alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + octanoyl-CoA = (2R)-2-O-[6-O-octanoyl-alpha-D-glucopyranosyl-(1->6)-alpha-D-glucopyranosyl]-glycerate + CoA

Direction not assertedBalancedRhea 56868

(S)-N-acetyl-1-phenylethylamine + H2O = (S)-1-phenylethylamine + acetate

Direction not assertedBalancedRhea 56872

(R)-N-acetyl-1-phenylethylamine + H2O = (R)-1-phenylethylamine + acetate

Direction not assertedBalancedRhea 56876

a 3beta-hydroxy-Delta(5)-steroid + NADP(+) = a 3-oxo-Delta(5)-steroid + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 56880

adenosine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(32) in tRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 56884

UDP-4-dehydro-6-deoxy-alpha-D-glucose = UDP-4-dehydro-beta-L-rhamnose

Direction not assertedBalancedRhea 56888

UDP-4-dehydro-beta-L-rhamnose + NADPH + H(+) = UDP-beta-L-rhamnose + NADP(+)

Direction not assertedBalancedRhea 56892

a carboxylate + ATP + H(+) = an acyl-AMP + diphosphate

Direction not assertedBalance undeterminableRhea 56896

a globoside GalGb4Cer + UDP-N-acetyl-alpha-D-glucosamine = a globoside GlcNAc-(beta1->6)-GalGb4Cer + UDP + H(+)

Left to rightBalance undeterminableRhea 56900

an acyl-AMP + CoA = an acyl-CoA + AMP + H(+)

Direction not assertedBalance undeterminableRhea 56904

(7S)-O-acetylsalutaridinol = thebaine + acetate + H(+)

Direction not assertedBalancedRhea 56908

(Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + NAD(+) + H2O = (E)-2-((N-methylformamido) methylene)succinate + NADH + 3 H(+)

Direction not assertedBalancedRhea 56912

3beta-hydroxy-5alpha-androstan-17-one + NADP(+) = 5alpha-androstan-3,17-dione + NADPH + H(+)

Direction not assertedBalancedRhea 56916

a medium-chain fatty acid + ATP + H(+) = a medium-chain fatty acyl-AMP + diphosphate

Direction not assertedBalance undeterminableRhea 56920

L-threonyl-[Goodpasture antigen-binding protein] + ATP = O-phospho-L-threonyl-[Goodpasture antigen-binding protein] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 56924

abieta-7,13-dien-18-al + reduced [NADPH--hemoprotein reductase] + O2 = abieta-7,13-dien-18-oate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 56928

androst-5-en-3beta,17beta-diol + NAD(+) = 17beta-hydroxy-androst-5-en-3-one + NADH + H(+)

Direction not assertedBalancedRhea 56932

17beta-hydroxy-androst-5-en-3-one = testosterone

Direction not assertedBalancedRhea 56936

5-(methylsulfanyl)-D-ribulose 1-phosphate = 2-(methylsulfanyl)acetaldehyde + dihydroxyacetone phosphate

Direction not assertedBalancedRhea 56940

D-ribulose 5-phosphate + AH2 = 1-deoxy-D-xylulose 5-phosphate + A + H2O

Direction not assertedBalancedRhea 56944

UTP + pyruvate = phosphoenolpyruvate + UDP + H(+)

Direction not assertedBalancedRhea 56948

CTP + pyruvate = CDP + phosphoenolpyruvate + H(+)

Direction not assertedBalancedRhea 56952

ITP + pyruvate = IDP + phosphoenolpyruvate + H(+)

Direction not assertedBalancedRhea 56956

a ribonucleoside 5'-triphosphate + pyruvate = a ribonucleoside 5'-diphosphate + phosphoenolpyruvate + H(+)

Direction not assertedBalance undeterminableRhea 56960

a 2'-deoxyribonucleoside 5'-triphosphate + pyruvate = a 2'-deoxyribonucleoside 5'-diphosphate + phosphoenolpyruvate + H(+)

Direction not assertedBalance undeterminableRhea 56964

dCTP + pyruvate = dCDP + phosphoenolpyruvate + H(+)

Direction not assertedBalancedRhea 56968

(R)-3-hydroxy-2-methylpropanoate + NAD(+) = (R)-2-methyl-3-oxopropanoate + NADH + H(+)

Direction not assertedBalancedRhea 56972

4-methylphenol + 2 oxidized [azurin] + H2O = 4-hydroxybenzyl alcohol + 2 reduced [azurin] + 2 H(+)

Direction not assertedBalance undeterminableRhea 56976

4-hydroxybenzyl alcohol + 2 oxidized [azurin] = 2 reduced [azurin] + 4-hydroxybenzaldehyde + 2 H(+)

Direction not assertedBalance undeterminableRhea 56980

(2E,6E)-farnesyl diphosphate + H2O = (6E)-nerolidol + diphosphate

Direction not assertedBalancedRhea 56984

germacra-1(10),4,11(13)-trien-12-oate + reduced [NADPH--hemoprotein reductase] + O2 = 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 56988

6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + H(+) = (+)-costunolide + H2O

Direction not assertedBalancedRhea 56992

aldehydo-D-apiose = apulose

Direction not assertedBalancedRhea 56996

streptothricin F + acetyl-CoA = N(beta)-acetylstreptothricin F + CoA + H(+)

Direction not assertedBalancedRhea 57000

streptothricin D + acetyl-CoA = N(beta)-acetylstreptothricin D + CoA + H(+)

Direction not assertedBalancedRhea 57004

5,5'-dehydrodivanillate + NADH + O2 + H(+) = 2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl + formaldehyde + NAD(+) + H2O

Direction not assertedBalancedRhea 57008

a menaquinone + sulfite + H2O = a menaquinol + sulfate

Direction not assertedBalance undeterminableRhea 57012

3,6-dichloro-2-methoxybenzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 3,6-dichlorosalicylate + formaldehyde + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 57016

apulose + ATP = apulose 4-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 57020

apulose 4-phosphate + D-glyceraldehyde 3-phosphate = D-xylulose 5-phosphate + dihydroxyacetone phosphate

Direction not assertedBalancedRhea 57024

N-methylnicotinate + FADH2 + O2 = (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FAD + H(+)

Direction not assertedBalancedRhea 57028

(E)-2-((N-methylformamido) methylene)succinate + 2 H2O + H(+) = succinate semialdehyde + methylamine + formate + CO2

Direction not assertedBalancedRhea 57032

[(1->6)-alpha-D-glucosyl](n) + sucrose = (1->3)-alpha-D-glucosyl-[(1->6)-alpha-D-glucosyl](n) + D-fructose

Direction not assertedBalance undeterminableRhea 57036

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