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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

1,051–1,100 of 18,558 reactions from Rhea

biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)
Direction not assertedBalancedRhea 14413
acetyl phosphate + L-lysine = N(6)-acetyl-L-lysine + phosphate + H(+)
Direction not assertedBalancedRhea 14417
N(2)-benzoyl-D-arginine-4-nitroanilide + H2O = N(2)-benzoyl-D-arginine + 4-nitroaniline + H(+)
Direction not assertedBalancedRhea 14421
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
Left to rightBalance undeterminableRhea 14425
a [oligopeptide](in) + ATP + H2O = a [oligopeptide](out) + ADP + phosphate + H(+)
Left to rightBalance undeterminableTransportRhea 14429
a tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate
Left to rightBalance undeterminableRhea 14433

L-lysine + O2 + H2O = 6-amino-2-oxohexanoate + H2O2 + NH4(+)

Direction not assertedBalancedRhea 14437

gentamicin C + acetyl-CoA = N(3)-acetylgentamycin C + CoA + H(+)

Direction not assertedBalance undeterminableRhea 14441

a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)

Left to rightBalance undeterminableRhea 14445

chlorophyllide a + NADP(+) = 3,8-divinyl chlorophyllide a + NADPH + H(+)

Direction not assertedBalancedRhea 14449

pentanoyl-CoA + glyoxylate + H2O = 3-propylmalate + CoA + H(+)

Direction not assertedBalancedRhea 14457

(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 14461

L-histidinol phosphate + H2O = L-histidinol + phosphate

Direction not assertedBalancedRhea 14465

2-aminomuconate 6-semialdehyde + NAD(+) + H2O = (2Z,4E)-2-aminomuconate + NADH + 2 H(+)

Direction not assertedBalancedRhea 14469

a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)

Right to leftBalance undeterminableRhea 14473

a medium-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]

Left to rightBalance undeterminableRhea 14477

2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate

Direction not assertedBalancedRhea 14481

(2E,6E)-farnesyl diphosphate + H2O = 10-epi-juneol + diphosphate

Direction not assertedBalancedRhea 14485

a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 2'-phosphate + H(+)

Direction not assertedBalance undeterminableRhea 14489

N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + H2O = L-arginyl-[dinitrogen reductase] + ADP-D-ribose

Direction not assertedBalance undeterminableRhea 14493

pyridoxine + A = isopyridoxal + AH2

Direction not assertedBalancedRhea 14497

L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+)

Left to rightBalancedRhea 14501

thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

Direction not assertedBalancedRhea 14505

mugineate + 2-oxoglutarate + O2 = 3-epihydroxymugineate + succinate + CO2 + H(+)

Direction not assertedBalancedRhea 14509

L-aspartyl-tRNA(Asn) + L-glutamine + ATP + H2O = L-asparaginyl-tRNA(Asn) + L-glutamate + ADP + phosphate + 2 H(+)

Direction not assertedBalancedRhea 14513

(E)-feruloyl-CoA + H2O = 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA

Direction not assertedBalancedRhea 14517

(2E)-geraniol + NADP(+) = (2E)-geranial + NADPH + H(+)

Direction not assertedBalancedRhea 14521

beta-cyclopiazonate + A = alpha-cyclopiazonate + AH2

Direction not assertedBalancedRhea 14525

D-ribose 5-phosphate + ADP + H(+) = ADP-D-ribose + phosphate

Direction not assertedBalancedRhea 14529

creatinine + H2O = creatine

Direction not assertedBalancedRhea 14533

1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H2O + H(+) = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)

Direction not assertedBalancedRhea 14537

choloyl-CoA + H2O = cholate + CoA + H(+)

Left to rightBalancedRhea 14541

nicotinamide + H2O = nicotinate + NH4(+)

Direction not assertedBalancedRhea 14545

(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + formate + H(+)

Direction not assertedBalancedRhea 14549

(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = cephalosporin C + 2-oxoglutarate

Direction not assertedBalancedRhea 14553

raucaffricine + H2O = vomilenine + D-glucose

Direction not assertedBalancedRhea 14557

piperidine + (E,E)-piperoyl-CoA = piperine + CoA + H(+)

Direction not assertedBalancedRhea 14561

(11Z)-hexadecenoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxo-(13Z)-octadecenoyl-[ACP] + holo-[ACP] + CO2

Direction not assertedBalance undeterminableRhea 14565

propane-1,2-diol = propanal + H2O

Direction not assertedBalancedRhea 14569

D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O

Direction not assertedBalancedRhea 14573

2 monodehydro-L-ascorbate radical + NADH + H(+) = 2 L-ascorbate + NAD(+)

Direction not assertedBalancedRhea 14581

gibberellin A12 + 4 reduced [2Fe-2S]-[ferredoxin] + 3 O2 + 5 H(+) = gibberellin A9 + 4 oxidized [2Fe-2S]-[ferredoxin] + CO2 + 4 H2O

Direction not assertedBalance undeterminableRhea 14585

luteolin + S-adenosyl-L-methionine = chrysoeriol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 14589

a CDP-1,2-diacyl-sn-glycerol + choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)

Direction not assertedBalance undeterminableRhea 14597

L-lysine + O2 = 5-aminopentanamide + CO2 + H2O

Direction not assertedBalancedRhea 14601

GDP-alpha-D-glucose + D-glucose 6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP + H(+)

Direction not assertedBalancedRhea 14605

D-sorbitol + NADP(+) = keto-L-sorbose + NADPH + H(+)

Direction not assertedBalancedRhea 14609

taurine(out) + ATP + H2O = taurine(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 14613

glutathione + NADP(+) + CoA = CoA-glutathione + NADPH + H(+)

Direction not assertedBalancedRhea 14617

(S)-2,3-epoxysqualene = lanosterol

Left to rightBalancedRhea 14621

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