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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

10,901–10,950 of 18,558 reactions from Rhea

a bacteriochlorophyllide d + 2 S-adenosyl-L-methionine + H2O = a bacteriochlorophyllide f + 2 5'-deoxyadenosine + 2 L-methionine + 2 H(+)
Direction not assertedBalance undeterminableRhea 55812
a bacteriochlorophyllide d + S-adenosyl-L-methionine + H2O = a 7(1)-hydroxybacteriochlorophyllide d + 5'-deoxyadenosine + L-methionine + H(+)
Direction not assertedBalance undeterminableRhea 55816
a 7(1)-hydroxybacteriochlorophyllide d + S-adenosyl-L-methionine + H2O = a 7(1),7(1)-dihydroxybacteriochlorophyllide d + 5'-deoxyadenosine + L-methionine + H(+)
Direction not assertedBalance undeterminableRhea 55820
a 7(1),7(1)-dihydroxybacteriochlorophyllide d = a bacteriochlorophyllide f + H2O
Direction not assertedBalance undeterminableRhea 55824
cortisol + reduced [NADPH--hemoprotein reductase] + O2 = 6beta-hydroxycortisol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Left to rightBalance undeterminableRhea 55828
cortisone + reduced [NADPH--hemoprotein reductase] + O2 = 6beta-hydroxycortisone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 55832

calcitriol + UDP-alpha-D-glucuronate = calcitriol 25-O-(beta-D-glucuronide) + UDP + H(+)

Left to rightBalancedRhea 55836

calcidiol + UDP-alpha-D-glucuronate = calcidiol 25-O-(beta-D-glucuronide) + UDP + H(+)

Left to rightBalancedRhea 55840

calcidiol + UDP-alpha-D-glucuronate = calcidiol 3-O-(beta-D-glucuronide) + UDP + H(+)

Left to rightBalancedRhea 55844

[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->6)-alpha-D-glucosyl-(1->4)-N,7-O-diacetyl-alpha-D-neuraminosyl](n) + n CoA

Direction not assertedBalance undeterminableRhea 55848

[(2->6)-alpha-D-glucosyl-(1->4)-N-acetyl-alpha-D-neuraminosyl](n) + n acetyl-CoA = [(2->6)-alpha-D-glucosyl-(1->4)-N,O(9)-diacetyl-alpha-D-neuraminosyl](n) + n CoA

Direction not assertedBalance undeterminableRhea 55852

all-trans-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-18-hydroxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 55856

all-trans-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-5,6-epoxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 55860

(S)-lactate + O2 = pyruvate + H2O2

Direction not assertedBalancedRhea 55868

N,N-dimethyl-1,4-phenylenediamine + anthranilate + 2 NAD(+) = 2-(4-dimethylaminophenyl)diazenylbenzoate + 2 NADH + 2 H(+)

Direction not assertedBalancedRhea 55872

apo-[aequorin] + coelenterazine = apo-[aequorin]--coelenterazine

Direction not assertedBalance undeterminableRhea 55876

apo-[aequorin]--coelenterazine + O2 = [aequorin]

Direction not assertedBalance undeterminableRhea 55880

[aequorin] + 3 Ca(2+) = [aequorin]--dioxetanone

Direction not assertedBalance undeterminableRhea 55884

[aequorin]--dioxetanone = excited state-[aequorin] + CO2

Direction not assertedBalance undeterminableRhea 55888

a 2-(all-trans-polyprenyl)phenol + NADPH + O2 + H(+) = a 3-(all-trans-polyprenyl)benzene-1,2-diol + NADP(+) + H2O

Direction not assertedBalance undeterminableRhea 55892

L-tryptophan + FADH2 + chloride + O2 = 5-chloro-L-tryptophan + FAD + 2 H2O

Direction not assertedBalancedRhea 55896

L-tryptophan + FADH2 + chloride + O2 = 6-chloro-L-tryptophan + FAD + 2 H2O

Direction not assertedBalancedRhea 55900

7-chloro-L-tryptophan + FADH2 + chloride + O2 = 6,7-dichloro-L-tryptophan + FAD + 2 H2O

Direction not assertedBalancedRhea 55904

(cis-1,4-isoprene)(n) + O2 = (4Z,8Z)-4,8-dimethyl-12-oxotrideca-4,8-dienal + (cis-1,4-isoprene)(n-3)

Direction not assertedBalance undeterminableRhea 55920

albendazole + reduced [NADPH--hemoprotein reductase] + O2 = albendazole S-oxide + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 55924

fenbendazole + reduced [NADPH--hemoprotein reductase] + O2 = fenbendazole S-oxide + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 55928

3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 55932

all-trans-4-hydroxyretinol + NAD(+) = all-trans-4-hydroxyretinal + NADH + H(+)

Left to rightBalancedRhea 55936

all-trans-3,4-didehydroretinol + NAD(+) = all-trans-3,4-didehydroretinal + NADH + H(+)

Left to rightBalancedRhea 55940

2-chloroethanol + 2 Fe(III)-[cytochrome c] = chloroacetaldehyde + 2 Fe(II)-[cytochrome c] + 2 H(+)

Direction not assertedBalance undeterminableRhea 55944

D-alanine + A + H2O = pyruvate + AH2 + NH4(+)

Direction not assertedBalancedRhea 55948

an inositol-1-phosphoceramide + GDP-alpha-D-mannose = a mannosylinositol-1-phospho-N-acyl-sphingoid base + GDP + H(+)

Direction not assertedBalance undeterminableRhea 55952

(9Z)-octadecenoate + AH2 + O2 = (12R)-hydroxy-(9Z)-octadecenoate + A + H2O

Direction not assertedBalancedRhea 55956

4-(trimethylamino)butanoate + ATP + CoA = 4-(trimethylamino)butanoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 55960

1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)

Left to rightBalancedRhea 55964

(+)-kolavelool + S-adenosyl-L-methionine = (+)-O-methylkolavelool + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 55968

ethanol + acetyl-CoA = ethyl acetate + CoA

Direction not assertedBalancedRhea 55972

thiosulfate + glutathione = S-sulfanylglutathione + sulfite + H(+)

Direction not assertedBalancedRhea 55976

a 1,2-saturated acyl-CoA + an acyl-CoA + H2O = an (R)-2-alkyl-3-oxoalkanoate + 2 CoA + H(+)

Direction not assertedBalance undeterminableRhea 55980

(R)-mandelonitrile + UDP-alpha-D-glucose = (R)-prunasin + UDP + H(+)

Direction not assertedBalancedRhea 55984

N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose

Left to rightBalance undeterminableRhea 55988

1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)

Left to rightBalancedRhea 55992

N(4)-(alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose

Direction not assertedBalance undeterminableRhea 55996

N(4)-(alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + beta-D-glucose

Direction not assertedBalance undeterminableRhea 56000

N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + H2O = N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + beta-D-mannose

Direction not assertedBalance undeterminableRhea 56004

N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose

Direction not assertedBalance undeterminableRhea 56008

N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + H2O = N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) + beta-D-mannose

Direction not assertedBalance undeterminableRhea 56012

N(4)-{alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlaNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,2) + H2O = N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) + beta-D-mannose

Direction not assertedBalance undeterminableRhea 56016

N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 7A1,2,3B2) + H2O = N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) + beta-D-mannose

Direction not assertedBalance undeterminableRhea 56020

N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 6A1,2B2) + H2O = N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + beta-D-mannose

Direction not assertedBalance undeterminableRhea 56024

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