Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

10,751–10,800 of 18,558 reactions from Rhea

5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 5'-deoxyadenosine + L-methionine + NH4(+) + H(+)
Direction not assertedBalancedRhea 55204
(4R)-hydroxysphinganine 1-phosphate = (2R)-hydroxyhexadecanal + phosphoethanolamine
Direction not assertedBalancedRhea 55208
(2R)-hydroxyhexadecanoyl-CoA = pentadecanal + formyl-CoA
Left to rightBalancedRhea 55212
(2E,6E,10E)-geranylgeranyl diphosphate = rhizathalene A + diphosphate
Direction not assertedBalancedRhea 55216
4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 6 Fe(II)-[cytochrome b5] + 3 O2 + 5 H(+) = 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O
Left to rightBalance undeterminableRhea 55220
4,4-dimethyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O
Direction not asserted

?

Balance undeterminable

Rhea 55224

4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-7-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 55228

3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + O2 + H(+) = 2 Fe(III)-[cytochrome b561] + 4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + H2O

Direction not assertedBalance undeterminableRhea 55232

1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O = 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + (9Z)-octadecenoate + H(+)

Left to rightBalancedRhea 55236

1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + (9Z)-octadecenoate + H(+)

Left to rightBalancedRhea 55240

4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 6 Fe(II)-[cytochrome b5] + 3 O2 + 5 H(+) = 4beta-methylzymosterol-4alpha-carboxylate + 6 Fe(III)-[cytochrome b5] + 4 H2O

Left to rightBalance undeterminableRhea 55244

1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)

Left to rightBalancedRhea 55248

1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = 2-octadecanoyl-sn-glycero-3-phosphocholine + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)

Left to rightBalancedRhea 55252

1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H(+)

Left to rightBalancedRhea 55256

2 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H(+)

Left to rightBalancedRhea 55260

N-(30-hydroxytriacontanoyl)-sphing-4-enine + 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol = N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine + di-(9Z,12Z)-octadecadienoylglycerol

Left to rightBalancedRhea 55264

(2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate = (R)-glycerate + alpha-D-glucose 1-phosphate

Direction not assertedBalancedRhea 55268

11-cis-retinol + tetradecanoyl-CoA = 11-cis-retinyl tetradecanoate + CoA

Left to rightBalancedRhea 55272

9-cis-retinol + tetradecanoyl-CoA = 9-cis-retinyl tetradecanoate + CoA

Left to rightBalancedRhea 55276

13-cis-retinol + tetradecanoyl-CoA = 13-cis-retinyl tetradecanoate + CoA

Left to rightBalancedRhea 55280

all-trans-retinol + tetradecanoyl-CoA = all-trans-retinyl tetradecanoate + CoA

Left to rightBalancedRhea 55284

tetradecan-1-ol + tetradecanoyl-CoA = tetradecyl tetradecanoate + CoA

Left to rightBalancedRhea 55288

pseudouridine(54) in tRNA + S-adenosyl-L-methionine = N(1)-methylpseudouridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 55292

13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoA

Left to rightBalancedRhea 55296

(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 55300

1-octadecanoyl-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 55304

1-octadecanoyl-sn-glycero-3-phosphate + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 55308

(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 55312

hydrogen sulfide + 3 NAD(+) + 3 H2O = sulfite + 3 NADH + 4 H(+)

Direction not assertedBalancedRhea 55316

1,2-diheptanoyl-sn-glycero-3-phosphocholine + all-trans-retinol--[retinol-binding protein] = all-trans-retinyl heptanoate + 2-heptanoyl-sn-glycero-3-phosphocholine + apo--[retinol-binding protein]

Left to rightBalance undeterminableRhea 55320

11-cis-retinol + hexadecanoyl-CoA = 11-cis-retinyl hexadecanoate + CoA

Left to rightBalancedRhea 55324

9-cis-retinol + hexadecanoyl-CoA = 9-cis-retinyl hexadecanoate + CoA

Left to rightBalancedRhea 55328

a 3'-hydroxyflavone + S-adenosyl-L-methionine = a 3'-methoxyflavone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 55332

a 5'-hydroxy-3'-methoxyflavone + S-adenosyl-L-methionine = a 3',5'-dimethoxyflavone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 55336

1-O-(9Z-octadecenyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoA

Left to rightBalancedRhea 55340

1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoA

Left to rightBalancedRhea 55344

all-trans-retinol = 9-cis-retinol

Left to rightBalancedRhea 55348

all-trans-retinol = 13-cis-retinol

Left to rightBalancedRhea 55352

11-cis-retinol = 13-cis-retinol

Left to rightBalancedRhea 55356

11-cis-retinol = 9-cis-retinol

Left to rightBalancedRhea 55360

6 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-nonaprenyl diphosphate + 6 diphosphate

Left to rightBalancedRhea 55364

(R)-carnitine + NADPH + O2 + H(+) = (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP(+) + H2O

Direction not assertedBalancedRhea 55368

methyl (-)-jasmonate + H2O = jasmonate + methanol + H(+)

Direction not assertedBalancedRhea 55372

2 a quinol + O2 = 2 a quinone + 2 H2O

Direction not assertedBalance undeterminableRhea 55376

a 3alpha-hydroxy bile acid CoA + NAD(+) = a 3-oxo bile acid CoA + NADH + H(+)

Direction not assertedBalancedRhea 55380

(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 6 isopentenyl diphosphate = tetra-trans,hexa-cis-undecaprenyl diphosphate + 6 diphosphate

Direction not assertedBalancedRhea 55384

(3R)-3-hydroxy-2,3-dihydrotabersonine + A = (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + AH2

Direction not assertedBalancedRhea 55388

an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 55392

(R)-carnitine + NADH + O2 + H(+) = (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD(+) + H2O

Direction not assertedBalancedRhea 55396

7-cyano-7-carbaguanosine(15) in tRNA + NH4(+) = archaeosine(15) in tRNA

Direction not assertedBalancedRhea 55400

Page 216 of 372