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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
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Reference

Evidence

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

10,601–10,650 of 18,558 reactions from Rhea

octanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctanoyl-CoA + succinate + CO2
Left to rightBalancedRhea 54600
decanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydecanoyl-CoA + succinate + CO2
Left to rightBalancedRhea 54604
N(epsilon)-GMP-L-lysyl-[protein] + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + 2 H(+) = a 5'-end (5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-lysyl-[protein]
Direction not assertedBalance undeterminableRhea 54608
3-methylbutanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxy-3-methylbutanoyl-CoA + succinate + CO2
Left to rightBalancedRhea 54612
heptadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyheptadecanoyl-CoA + succinate + CO2
Left to rightBalancedRhea 54616
eicosanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyeicosanoyl-CoA + succinate + CO2
Left to rightBalancedRhea 54620

octadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctadecanoyl-CoA + succinate + CO2

Left to rightBalancedRhea 54624

dodecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydodecanoyl-CoA + succinate + CO2

Left to rightBalancedRhea 54628

tetradecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxytetradecanoyl-CoA + succinate + CO2

Left to rightBalancedRhea 54632

(13E)-labda-7,13-dien-15-yl diphosphate = labda-7,13(16),14-triene + diphosphate

Direction not assertedBalancedRhea 54636

(+)-copalyl diphosphate = (12E)-labda-8(17),12,14-triene + diphosphate

Direction not assertedBalancedRhea 54640

trans-4-hydroxy-L-proline = (S)-1-pyrroline-5-carboxylate + H2O + H(+)

Direction not assertedBalancedRhea 54644

ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + H2O

Direction not assertedBalancedRhea 54648

peregrinol diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + H2O

Direction not assertedBalancedRhea 54652

linalool = (2E)-geraniol

Direction not assertedBalancedRhea 54656

an aromatic (S)-hydroxynitrile = an aromatic aldehyde + hydrogen cyanide

Direction not assertedBalance undeterminableRhea 54660

(3S,22S)-2,3:22,23-diepoxysqualene = pre-alpha-onocerin

Direction not assertedBalancedRhea 54664

pre-alpha-onocerin = alpha-onocerin

Direction not assertedBalancedRhea 54668

(+)-kolavenyl diphosphate + H2O = (+)-kolavelool + diphosphate

Direction not assertedBalancedRhea 54672

(2E,6E,10E)-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate

Direction not assertedBalancedRhea 54676

(2E,6E,10E)-geranylgeranyl diphosphate = (-)-kolavenyl diphosphate

Direction not assertedBalancedRhea 54684

alliin = allylsulfenate + 2-aminoprop-2-enoate

Direction not assertedBalancedRhea 54688

(2E,6E,10E)-geranylgeranyl diphosphate = (13E)-labda-7,13-dien-15-yl diphosphate

Direction not assertedBalancedRhea 54692

holo-[4-hydroxyphenylalkanoate synthase] + 4-hydroxybenzoate + ATP = 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 54696

4-hydroxybenzoyl-5'-AMP + holo-[4-hydroxyphenylalkanoate synthase] = 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 54700

N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 54704

N-terminal N,N-dimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 54708

N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)

Direction not assertedBalance undeterminableRhea 54712

N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 54716

N-terminal N,N-dimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 54720

N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)

Direction not assertedBalance undeterminableRhea 54724

N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-CoA = N(6)-biotinyl-L-lysyl-[protein] + malonyl-CoA

Direction not assertedBalance undeterminableRhea 54728

N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 54732

N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalance undeterminableRhea 54736

9alpha,11alpha-methylene thromboxane A2 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-9alpha,11alpha-methylene thromboxane A2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 54740

9alpha,11alpha-methylene thromboxane A2 + reduced [NADPH--hemoprotein reductase] + O2 = 18-hydroxy-9alpha,11alpha-methylene thromboxane A2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 54744

firefly L-luciferin + ATP + CoA = L-firefly luciferyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 54748

methanophenazine + reduced coenzyme F420-(gamma-L-Glu)(n) = dihydromethanophenazine + oxidized coenzyme F420-(gamma-L-Glu)(n) + H(+)

Direction not assertedBalance undeterminableRhea 54752

deamido-NAD(+) + hydrogencarbonate = pyridinium-3,5-dicarboxylate mononucleotide + AMP + 2 H(+)

Direction not assertedBalancedRhea 54756

pyridinium-3,5-dicarboxylate mononucleotide + ATP + H(+) = 5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + diphosphate

Direction not assertedBalancedRhea 54760

5-carboxy-1-(5-O-phospho-beta-D-ribofuranosyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine = [LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)

Direction not assertedBalance undeterminableRhea 54764

[LarE protein]-S-[5-carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium-3-carbonyl]-L-cysteine = [LarE protein]-dehydroalanine + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide + H(+)

Direction not assertedBalance undeterminableRhea 54768

pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide + ATP + H(+) = 1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + diphosphate

Direction not assertedBalancedRhea 54772

1-(5-O-phospho-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl adenylate + [LarE protein]-L-cysteine = [LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine + AMP + H(+)

Direction not assertedBalance undeterminableRhea 54776

[LarE protein]-S-[1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridinium-3-carbonyl]-L-cysteine = pyridinium-3,5-bisthiocarboxylate mononucleotide + [LarE protein]-dehydroalanine + H(+)

Direction not assertedBalance undeterminableRhea 54780

Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = pyridinium-3,5-bisthiocarboxylate mononucleotide + Ni(2+)

Direction not assertedBalancedRhea 54784

pyridinium-3,5-dicarboxylate mononucleotide + [LarE protein]-L-cysteine + ATP = [LarE protein]-dehydroalanine + pyridinium-3-carboxylate-5-thiocarboxylate mononucleotide + AMP + diphosphate + H(+)

Direction not assertedBalance undeterminableRhea 54788

N(7)-methyl-GTP + L-histidyl-[protein] = N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein] + diphosphate

Direction not assertedBalance undeterminableRhea 54792

a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP(+) = an (R)-2-alkyl-3-oxoalkanoate + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 54796

N(tele)-(N(7)-methylguanosine 5'-phospho)-L-histidyl-[protein] + a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + L-histidyl-[protein]

Direction not assertedBalance undeterminableRhea 54800

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