Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

10,151–10,200 of 18,558 reactions from Rhea

S-(hercyn-2-yl)-L-cysteine S-oxide + H2O = 2-sulfenohercynine + pyruvate + NH4(+)
Direction not assertedBalancedRhea 52780
2-sulfenohercynine + AH2 + H(+) = ergothioneine + A + H2O
Direction not assertedBalancedRhea 52784
chlorophyll a + 2 H(+) = pheophytin a + Mg(2+)
Direction not assertedBalancedRhea 52788
chlorophyllide a + 2 H(+) = pheophorbide a + Mg(2+)
Direction not assertedBalancedRhea 52792
Ni-sirohydrochlorin + 2 H(+) = sirohydrochlorin + Ni(2+)
Direction not assertedBalancedRhea 52796
acetoacetyl-CoA + L-isoleucine + ATP = tenuazonic acid + AMP + diphosphate + CoA + 2 H(+)
Direction not assertedBalancedRhea 52800
(2E,6E)-farnesyl diphosphate = (+)-eremophilene + diphosphate

Direction not assertedBalancedRhea 52804

adenosine in U6 snRNA + S-adenosyl-L-methionine = N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 52808

1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)

ReversibleBalancedRhea 52812

an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)

Direction not assertedBalance undeterminableRhea 52816

succinyl-CoA + L-serine = O-succinyl-L-serine + CoA

Direction not assertedBalancedRhea 52820

(1R,4R)-dihydrocarvone + NADPH + O2 + H(+) = (4R,7R)-4-isopropenyl-7-methyloxepan-2-one + NADP(+) + H2O

Direction not assertedBalancedRhea 52824

(1S,4R)-isodihydrocarvone + NADPH + O2 + H(+) = (3S,6R)-6-isopropenyl-3-methyloxepan-2-one + NADP(+) + H2O

Direction not assertedBalancedRhea 52828

1-hydroxylimonen-2-one + NADPH + O2 + H(+) = 7-hydroxy-4-isopropenyl-7-methyloxepan-2-one + NADP(+) + H2O

Direction not assertedBalancedRhea 52832

indole + NADH + O2 + H(+) = indoxyl + NAD(+) + H2O

Direction not assertedBalancedRhea 52836

vanillate + UDP-alpha-D-glucose = 1-O-(4-hydroxy-3-methoxybenzoyl)-beta-D-glucose + UDP

Direction not assertedBalancedRhea 52840

3,4-dihydroxybenzoate + UDP-alpha-D-glucose = 1-O-(3,4-dihydroxy-benzoyl)-beta-D-glucose + UDP

Direction not assertedBalancedRhea 52844

carboxy-S-adenosyl-L-methionine + 5-hydroxyuridine(34) in tRNA = 5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 52848

a C2-C8-saturated long-chain fatty acyl-[ACP] + 2 reduced [flavodoxin] + 3 O2 = 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 2 oxidized [flavodoxin] + 3 H2O + 3 H(+)

Direction not assertedBalance undeterminableRhea 52852

(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + N,N-dimethylglycine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + reduced [electron-transfer flavoprotein]

Direction not assertedBalance undeterminableRhea 52856

a short-chain fatty acid + ATP + CoA = a short-chain fatty acyl-CoA + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 52860

an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)

Left to rightBalance undeterminableRhea 52864

17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP + H(+)

Left to rightBalancedRhea 52868

17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+)

Left to rightBalancedRhea 52872

16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 3-O-(beta-D-glucuronate) + UDP + H(+)

Left to rightBalancedRhea 52876

16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + UDP + H(+)

Left to rightBalancedRhea 52880

N-phenylhydroxylamine + 2 NADP(+) + H2O = nitrobenzene + 2 NADPH + 2 H(+)

Direction not assertedBalancedRhea 52884

N-phenylhydroxylamine + NADP(+) = nitrosobenzene + NADPH + H(+)

Direction not assertedBalancedRhea 52888

nitrosobenzene + NADP(+) + H2O = nitrobenzene + NADPH + H(+)

Direction not assertedBalancedRhea 52892

Ni-sirohydrochlorin + 2 L-glutamine + 2 ATP + 2 H2O = Ni-sirohydrochlorin a,c-diamide + 2 L-glutamate + 2 ADP + 2 phosphate + 2 H(+)

Direction not assertedBalancedRhea 52896

Ni-sirohydrochlorin a,c-diamide + 3 AH2 + ATP + H2O = 15,17(3)-seco-F430-17(3)-acid + 3 A + ADP + phosphate

Direction not assertedBalancedRhea 52900

15,17(3)-seco-F430-17(3)-acid + ATP = coenzyme F430 + ADP + phosphate

Direction not assertedBalancedRhea 52904

3-dimethylallyl-4-hydroxyphenylpyruvate + O2 = 3-dimethylallyl-4-hydroxymandelate + CO2

Direction not assertedBalancedRhea 52908

3-dimethylallyl-4-hydroxymandelate + O2 = 3-dimethylallyl-4-hydroxybenzoate + CO2 + H2O

Direction not assertedBalancedRhea 52912

16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + UDP + H(+)

Left to rightBalancedRhea 52916

16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + UDP + H(+)

Left to rightBalancedRhea 52920

16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 3-O-(beta-D-glucuronate) + UDP + H(+)

Left to rightBalancedRhea 52924

3',3'-c-di-GMP + 2 H2O = 2 GMP + 2 H(+)

Direction not assertedBalancedRhea 52928

3-oxobutanoyl-[ACP] + acetyl-[ACP] + H2O = (3S)-hydroxy-3-methylglutaryl-[ACP] + holo-[ACP] + H(+)

Direction not assertedBalance undeterminableRhea 52936

chenodeoxycholate + UDP-alpha-D-glucuronate = chenodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP

Left to rightBalancedRhea 52940

cholate + UDP-alpha-D-glucuronate = choloyl-24-O-(beta-D-glucuronate) + UDP

Direction not assertedBalancedRhea 52944

deoxycholate + UDP-alpha-D-glucuronate = deoxycholoyl-24-O-(beta-D-glucuronate) + UDP

Left to rightBalancedRhea 52948

lithocholate + UDP-alpha-D-glucuronate = lithocholoyl-24-O-(beta-D-glucuronate) + UDP

Left to rightBalancedRhea 52952

hyodeoxycholate + UDP-alpha-D-glucuronate = hyodeoxycholoyl-24-O-(beta-D-glucuronate) + UDP

Left to rightBalancedRhea 52956

hyocholate + UDP-alpha-D-glucuronate = hyocholoyl-24-O-(beta-D-glucuronate) + UDP

Left to rightBalancedRhea 52960

hyodeoxycholate + UDP-alpha-D-glucuronate = hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP + H(+)

Left to rightBalancedRhea 52964

hyocholate + UDP-alpha-D-glucuronate = hyocholate 6-O-(beta-D-glucuronate) + UDP + H(+)

Left to rightBalancedRhea 52968

a C2-C8-saturated long-chain fatty acyl-[ACP] + reduced [flavodoxin] + O2 = a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + oxidized [flavodoxin] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 52972

a (7S)-7-hydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + reduced [flavodoxin] + O2 = a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + oxidized [flavodoxin] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 52976

a (7R,8R)-7,8-dihydroxy-C2-C8-saturated long-chain fatty acyl-[ACP] + reduced [flavodoxin] + O2 = 7-oxoheptanoyl-[ACP] + a fatty aldehyde + oxidized [flavodoxin] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 52980

Page 204 of 372