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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Organisms
Materials
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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

951–1,000 of 18,558 reactions from Rhea

choloyl-CoA + glycine = glycocholate + CoA + H(+)
Left to rightBalancedRhea 14001
L,L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4(+)
Left to rightBalancedRhea 14005
2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate
Direction not assertedBalancedRhea 14009
taurolithocholate + 3'-phosphoadenylyl sulfate = taurolithocholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)
Left to rightBalancedRhea 14013
beta-nicotinamide D-riboside + ATP = beta-nicotinamide D-ribonucleotide + ADP + H(+)
Direction not assertedBalancedRhea 14017
ecdysone + AH2 + O2 = 20-hydroxyecdysone + A + H2O
Direction not assertedBalancedRhea 14021
L-sepiapterin + H2O + H(+) = (S)-xanthopterin-B2 + NH4(+)

? Direction not asserted

Balanced

Rhea 14025

selenite + A + H2O = selenate + AH2

Direction not assertedBalancedRhea 14029

sn-glycero-3-phospho-1D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + glycerol + H(+)

Left to rightBalancedRhea 14033

4,5beta-dihydrocortisone + NADP(+) = cortisone + NADPH + H(+)

Right to leftBalancedRhea 14037

(R)-vicianin + H2O = vicianose + mandelonitrile

Direction not assertedBalancedRhea 14041

1-carboxyvinyl carboxyphosphonate + H(+) = 3-(hydrohydroxyphosphoryl)pyruvate + CO2

Direction not assertedBalancedRhea 14045

taxa-4(5),11(12)-diene + reduced [NADPH--hemoprotein reductase] + O2 = taxa-4(20),11-dien-5alpha-ol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 14049

D-arabinose 5-phosphate + phosphoenolpyruvate + H2O = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate

Direction not assertedBalancedRhea 14053

a glycerophospholipid + a 1,2-diacyl-sn-glycerol = a monoacylglycerophospholipid + a triacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 14057

N-(carboxymethyl)-D-alanine + NAD(+) + H2O = glycine + pyruvate + NADH + H(+)

Direction not assertedBalancedRhea 14061

scyllo-inosose = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O

Direction not assertedBalancedRhea 14065

D-fructose + NADP(+) = 5-dehydro-D-fructose + NADPH + H(+)

Direction not assertedBalancedRhea 14069

3-hydroxy-L-glutamate + H(+) = 4-amino-3-hydroxybutanoate + CO2

Direction not assertedBalancedRhea 14073

3-oxopropanoate + L-alanine = beta-alanine + pyruvate

Right to leftBalancedRhea 14077

(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate

Direction not assertedBalancedRhea 14081

5-methylaminomethyl-2-thiouridine(34) in tRNA + (2E)-geranyl diphosphate = 5-methylaminomethyl-S-(2E)-geranyl-thiouridine(34) in tRNA + diphosphate

Direction not assertedBalancedRhea 14085

glycine + 2-oxoglutarate = glyoxylate + L-glutamate

Direction not assertedBalancedRhea 14089

L-tryptophan + 2-oxoglutarate = indole-3-pyruvate + L-glutamate

Direction not assertedBalancedRhea 14093

3-phenylpyruvate + L-aspartate = oxaloacetate + L-phenylalanine

Direction not assertedBalancedRhea 14097

[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O

Direction not assertedBalance undeterminableRhea 14101

L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)

Right to leftBalancedRhea 14105

L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)

Right to leftBalancedRhea 14109

a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H2O = a 3'-end 2'-deoxyribonucleotide-DNA + phosphate

Direction not assertedBalance undeterminableRhea 14113

[(1->4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1->4)-alpha-D-galacturonosyl](n-1)

Direction not assertedBalance undeterminableRhea 14117

3,4-dihydroxy-5-(all-trans-hexaprenyl)benzoate + S-adenosyl-L-methionine = 4-hydroxy-3-methoxy-5-(all-trans-hexaprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 14121

2 raffinose = 1(F)-alpha-D-galactosylraffinose + sucrose

Direction not assertedBalancedRhea 14125

cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H(+)

Direction not assertedBalancedRhea 14129

(-)-tabersonine + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxytabersonine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 14133

beta-D-galactosyl-(1<->1)-sphing-4-enine + 3'-phosphoadenylyl sulfate = 6-O-sulfo-beta-D-galactosyl-(1<->1)-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 14137

glutathione disulfide + sulfite + AMP + 2 H(+) = adenosine 5'-phosphosulfate + 2 glutathione

Direction not assertedBalancedRhea 14141

guanidinoacetate + ATP = phosphoguanidinoacetate + ADP + H(+)

Direction not assertedBalancedRhea 14145

luteolin 7-O-beta-D-glucuronide + UDP-alpha-D-glucuronate = luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP + H(+)

Direction not assertedBalancedRhea 14149

17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-alpha-D-glucosaminyl)estradiol 3-glucosiduronate + UDP + H(+)

Direction not assertedBalancedRhea 14153

triphosphate + H2O = phosphate + diphosphate

Left to rightBalancedRhea 14157

1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)

Direction not assertedBalancedRhea 14161

L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H(+)

Left to rightBalancedRhea 14165

glutarate + ATP + CoA = glutaryl-CoA + ADP + phosphate

Direction not assertedBalancedRhea 14169

dimethylallyl diphosphate + L-tryptophan = 4-(3-methylbut-2-enyl)-L-tryptophan + diphosphate

Direction not assertedBalancedRhea 14173

(R)-amygdalin + H2O = (R)-prunasin + D-glucose

Direction not assertedBalancedRhea 14177

N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2

Direction not assertedBalancedRhea 14181

3-phenylpyruvate + H(+) = 2-phenylacetaldehyde + CO2

Direction not assertedBalancedRhea 14185

D-tryptophan + O2 = N-formyl-D-kynurenine

Direction not assertedBalancedRhea 14189

3-hydroxybenzoate + AH2 + O2 = 2,3-dihydroxybenzoate + A + H2O

Direction not assertedBalancedRhea 14193

L-aspartate + NH4(+) + ATP = L-asparagine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 14197

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