Loading the page.
Subsystem: Drug metabolism Remove
51–100 of 572 reactions in Drug metabolism
ATP[c] + H2O[c] + 31-DMT or M-II, 31-O-desmethyl tacrolimus[c] = ADP[c] + H+[c] + Pi[c] + 31-DMT or M-II, 31-O-desmethyl tacrolimus[e]
Left to rightBalancedTransportHuman-GEM MAR12358
31-DMT or M-II, 31-O-desmethyl tacrolimus[c] = 31-DMT or M-II, 31-O-desmethyl tacrolimus[e]
ReversibleBalancedTransportHuman-GEM MAR12359
H+[r] + 2 NADPH[r] + 2 O2[r] + pravastatin[r] = 2 H2O[r] + 2 NADP+[r] + 3'-alpha,5'beta-dihydroxy-pravastatin / 3'-alpha5'beta6'beta-trihydroxy pravastatin[r]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR12360
3'-alpha,5'beta-dihydroxy-pravastatin / 3'-alpha5'beta6'beta-trihydroxy pravastatin[c] = 3'-alpha,5'beta-dihydroxy-pravastatin / 3'-alpha5'beta6'beta-trihydroxy pravastatin[e]
ReversibleBalancedTransportHuman-GEM MAR12361
HCO3-[c] + 3'-alpha,5'beta-dihydroxy-pravastatin / 3'-alpha5'beta6'beta-trihydroxy pravastatin[e] = HCO3-[e] + 3'-alpha,5'beta-dihydroxy-pravastatin / 3'-alpha5'beta6'beta-trihydroxy pravastatin[c]
ReversibleBalancedTransportHuman-GEM MAR12362
H+[r] + NADPH[r] + O2[r] + simvastatin lactone form[r] = NADP+[r] + 3',5'-dihydrodiol-simvastatin-lactone form[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12363
ATP[c] + H2O[c] + 3',5'-dihydrodiol-simvastatin-lactone form[c] = ADP[c] + H+[c] + Pi[c] + 3',5'-dihydrodiol-simvastatin-lactone form[e]
Left to rightBalancedTransportHuman-GEM MAR12364
3-hydroxy S-ibuprofen-glucuronide[c] = 3-hydroxy S-ibuprofen-glucuronide[e]
ReversibleBalancedTransportHuman-GEM MAR12365
3-hydroxy R-ibuprofen[c] = 3-hydroxy R-ibuprofen[e]
ReversibleBalancedTransportHuman-GEM MAR12366
UDP-glucuronate[r] + 3-hydroxy S-ibuprofen[r] = UDP[r] + 3-hydroxy S-ibuprofen-glucuronide[r]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR12367
3-hydroxy S-ibuprofen[c] = 3-hydroxy S-ibuprofen[e]
ReversibleBalancedTransportHuman-GEM MAR12368
H2O[c] + 3''-hydroxy-lovastatin lactone form[c] = H+[c] + 3''-hydroxy-lovastatin acid form[c]
Left to rightBalancedEC 3.1.1.2Human-GEM MAR12369
ATP[c] + H2O[c] + 3''-hydroxy-lovastatin acid form[c] = ADP[c] + H+[c] + Pi[c] + 3''-hydroxy-lovastatin acid form[e]
Left to rightBalancedTransportHuman-GEM MAR12370
2 CoA[m] + 2 FAD[m] + 2 H2O[m] + 2 NAD+[m] + 3'-S-hydroxy-pravastatin-CoA[m] = 2 acetyl-CoA[m] + 2 FADH2[m] + 2 H+[m] + 2 NADH[m] + O2[m] + 3'-S-hydroxy-pravastatin-tetranor-CoA[m]
Left to rightBalancedEC 1.3.99.-, 4.2.1.17, 1.1.1.211, 2.3.1.16Human-GEM MAR12371
2 CoA[x] + 2 H2O[x] + 2 NAD+[x] + O2[x] + 3'-S-hydroxy-pravastatin-CoA[x] = 2 acetyl-CoA[x] + 2 H+[x] + 2 H2O2[x] + 2 NADH[x] + 3'-S-hydroxy-pravastatin-tetranor-CoA[x]
Left to rightBalancedEC 1.3.3.6, 4.2.1.17, 1.1.1.35, 2.3.1.16Human-GEM MAR12372
ATP[c] + H2O[c] + 3'-S-hydroxy-pravastatin-tetranor[c] = ADP[c] + H+[c] + Pi[c] + 3'-S-hydroxy-pravastatin-tetranor[e]
Left to rightBalancedTransportHuman-GEM MAR12373
3'-S-hydroxy-pravastatin-tetranor[c] = 3'-S-hydroxy-pravastatin-tetranor[e]
ReversibleBalancedTransportHuman-GEM MAR12374
H+[r] + NADPH[r] + O2[r] + pravastatin[r] = H2O[r] + NADP+[r] + 3'-S-hydroxy-pravastatin[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.94Human-GEM MAR12375
ATP[c] + H2O[c] + 3'-S-hydroxy-pravastatin[c] = ADP[c] + H+[c] + Pi[c] + 3'-S-hydroxy-pravastatin[e]
Left to rightBalancedTransportHuman-GEM MAR12376
3'-S-hydroxy-pravastatin[c] = 3'-S-hydroxy-pravastatin[e]
ReversibleBalancedTransportHuman-GEM MAR12377
HCO3-[c] + 3'-S-hydroxy-pravastatin[e] = HCO3-[e] + 3'-S-hydroxy-pravastatin[c]
ReversibleBalancedTransportHuman-GEM MAR12378
H2O[c] + 3'-hydroxy-simvastatin-lactone form[c] = H+[c] + 3'-hydroxy-simvastatin-acid form[c]
Left to rightBalancedEC 3.1.1.2Human-GEM MAR12379
ATP[c] + H2O[c] + 3'-hydroxy-simvastatin-acid form[c] = ADP[c] + H+[c] + Pi[c] + 3'-hydroxy-simvastatin-acid form[e]
Left to rightBalancedTransportHuman-GEM MAR12380
6'-beta-hydroxy simvastatin lactone[r] = 3'-hydroxy-simvastatin-lactone form[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12381
pravastatin[c] = 3-alpha-iso-pravastatin[c]
Left to rightBalancedHuman-GEM MAR12382
ATP[c] + H2O[c] + 3-alpha-iso-pravastatin[c] = ADP[c] + H+[c] + Pi[c] + 3-alpha-iso-pravastatin[e]
Left to rightBalancedTransportHuman-GEM MAR12383
3-alpha-iso-pravastatin[c] = 3-alpha-iso-pravastatin[e]
ReversibleBalancedTransportHuman-GEM MAR12384
HCO3-[c] + 3-alpha-iso-pravastatin[e] = HCO3-[e] + 3-alpha-iso-pravastatin[c]
ReversibleBalancedTransportHuman-GEM MAR12385
SAM[c] + 3-hydroxy-acetaminophen[c] = H+[c] + SAH[c] + 3-methoxy-acetaminophen[c]
Left to rightBalancedHuman-GEM MAR12386
H+[r] + NADPH[r] + O2[r] + acetaminophen/paracetamol[r] = H2O[r] + NADP+[r] + 3-hydroxy-acetaminophen[r]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR12387
ATP[c] + H2O[c] + 3-hydroxy-acetaminophen[c] = ADP[c] + H+[c] + Pi[c] + 3-hydroxy-acetaminophen[e]
Left to rightBalancedTransportHuman-GEM MAR12388
ATP[c] + H2O[c] + 4-beta-OH-gliclazide[c] = ADP[c] + H+[c] + Pi[c] + 4-beta-OH-gliclazide[e]
Left to rightBalancedTransportHuman-GEM MAR12389
H+[r] + NADPH[r] + O2[r] + Gliclazide[r] = H2O[r] + NADP+[r] + 4-beta-OH-gliclazide[r]
Left to rightBalancedHuman-GEM MAR12390
4-beta-OH-gliclazide[c] = 4-beta-OH-gliclazide[e]
ReversibleBalancedTransportHuman-GEM MAR12391
H+[r] + NADPH[r] + O2[r] + atorvastatin-acid[r] = H2O[r] + NADP+[r] + 4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12392
H2O[c] + 4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[c] = H+[c] + 4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[c]
Left to rightBalancedEC 3.1.1.2Human-GEM MAR12393
ATP[c] + H2O[c] + 4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[c] = ADP[c] + H+[c] + Pi[c] + 4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[e]
Left to rightBalancedTransportHuman-GEM MAR12394
4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[c] = 4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[e]
ReversibleBalancedTransportHuman-GEM MAR12395
HCO3-[c] + 4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[e] = HCO3-[e] + 4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[c]
ReversibleBalancedTransportHuman-GEM MAR12396
H+[r] + NADPH[r] + O2[r] + atorvastatin-lactone[r] = H2O[r] + NADP+[r] + 4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12397
ATP[c] + 4-hydroxy-atorvastatin-acid / para-hydroxy-atorvastatin acid[c] = AMP[c] + PPi[c] + 4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[c]
Left to rightBalancedHuman-GEM MAR12398
ATP[c] + H2O[c] + 4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[c] = ADP[c] + H+[c] + Pi[c] + 4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[e]
Left to rightBalancedTransportHuman-GEM MAR12399
4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[c] = 4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[e]
ReversibleBalancedTransportHuman-GEM MAR12400
HCO3-[c] + 4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[e] = HCO3-[e] + 4-hydroxy-atorvastatin-lactone / para-hydroxy-atorvastatin lactone[c]
ReversibleBalancedTransportHuman-GEM MAR12401
4-OH-midazolam-glucuronide[c] = 4-OH-midazolam-glucuronide[e]
ReversibleBalancedTransportHuman-GEM MAR12402
UDP-glucuronate[r] + 4-OH-midazolam[r] = H+[r] + UDP[r] + 4-OH-midazolam-glucuronide[r]
Left to rightBalancedEC 2.4.1.17Human-GEM MAR12403
H+[r] + NADPH[r] + O2[r] + Midazolam[r] = H2O[r] + NADP+[r] + 4-OH-midazolam[r]
Left to rightBalancedEC 1.14.13.-, 1.14.14.1Human-GEM MAR12404
4-OH-midazolam[c] = 4-OH-midazolam[e]
ReversibleBalancedTransportHuman-GEM MAR12405
H+[r] + NADPH[r] + O2[r] + triol metabolite of pravastatin[r] = 2 H2O[r] + NADP+[r] + 3-keto-5,6,-dihydroxy-pravastatin[r]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR12406
ATP[c] + H2O[c] + 3-keto-5,6,-dihydroxy-pravastatin[c] = ADP[c] + H+[c] + Pi[c] + 3-keto-5,6,-dihydroxy-pravastatin[e]
Left to rightBalancedTransportHuman-GEM MAR12407