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Subsystem: Bile acid biosynthesis Remove
51–100 of 256 reactions in Bile acid biosynthesis
3alpha,7alpha-dihydroxy-5beta-cholestan-27-al[m] + H2O[m] + NADP+[m] = 3alpha,7alpha-dihydroxy-5beta-cholestanate[m] + 2 H+[m] + NADPH[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01691
3alpha,7alpha-dihydroxy-5beta-cholestan-26-al[c] + H2O[c] + NAD+[c] = 3alpha,7alpha-dihydroxy-5beta-cholestanate[c] + 2 H+[c] + NADH[c]
ReversibleBalancedEC 1.2.1.3Human-GEM MAR01692
3alpha,7alpha-dihydroxy-5beta-cholestan-26-al[m] + NADPH[m] + O2[m] = 3alpha,7alpha-dihydroxy-5beta-cholestanate[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01693
3alpha,7alpha-dihydroxy-5beta-cholestanate[c] + ATP[c] + CoA[c] = 25(R)DHCA-CoA[c] + AMP[c] + PPi[c]
Left to rightBalancedEC 6.2.1.28, 6.2.1.7Human-GEM MAR01697
3alpha,7alpha-dihydroxy-5beta-cholestanate[r] + ATP[r] + CoA[r] = 25(R)DHCA-CoA[r] + AMP[r] + PPi[r]
Left to rightBalancedEC 6.2.1.28, 6.2.1.7Human-GEM MAR01699
3alpha,7alpha-dihydroxy-5beta-cholestanate[x] + ATP[x] + CoA[x] = 25(R)DHCA-CoA[x] + AMP[x] + PPi[x]
Left to rightBalancedEC 6.2.1.28, 6.2.1.7Human-GEM MAR01700
25(R)DHCA-CoA[x] = 25(S)DHCA-CoA[x]
ReversibleBalancedEC 5.1.99.4Human-GEM MAR01703
25(S)DHCA-CoA[x] + FAD[x] = 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA[x] + FADH2[x]
Left to rightBalancedEC 1.17.99.3Human-GEM MAR01704
3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA[x] + H2O[x] = (24R,25R)3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA[x]
Left to rightBalancedEC 4.2.1.107Human-GEM MAR01706
(24R,25R)3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA[x] + NAD+[x] = 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestanoyl coa[x] + H+[x] + NADH[x]
Left to rightBalancedEC 4.2.1.107Human-GEM MAR01708
3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestanoyl coa[x] + CoA[x] = chenodeoxycholoyl-CoA[x] + propanoyl-CoA[x]
Left to rightBalancedEC 2.3.1.176Human-GEM MAR01710
7 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA[x] + 3 CO2[x] + 8 CoA[x] + 2 H2O[x] = 8 propanoyl-CoA[x] + 7 chenodeoxyglycocholoyl-CoA[x]
Left to rightBalancedEC 2.7.7.4Human-GEM MAR01711
chenodeoxycholoyl-CoA[x] + H2O[x] = chenodiol[x] + CoA[x] + H+[x]
Left to rightBalancedEC 3.1.2.2Human-GEM MAR01716
chenodeoxycholoyl-CoA[c] + H2O[c] = chenodiol[c] + CoA[c] + H+[c]
Left to rightBalancedEC 3.1.2.2Human-GEM MAR01718
chenodeoxycholoyl-CoA[x] + taurine[x] = CoA[x] + taurochenodeoxycholate[x]
Left to rightBalancedEC 2.3.1.65Human-GEM MAR01720
chenodeoxycholoyl-CoA[c] + glycine[c] = CoA[c] + glycochenodeoxycholate[c]
Left to rightBalancedEC 2.3.1.65Human-GEM MAR01722
chenodeoxycholoyl-CoA[c] + taurine[c] = CoA[c] + taurochenodeoxycholate[c]
Left to rightBalancedEC 2.3.1.65Human-GEM MAR01723
ATP[c] + chenodiol[c] + CoA[c] = AMP[c] + chenodeoxycholoyl-CoA[c] + PPi[c]
Left to rightBalancedEC 6.2.1.7Human-GEM MAR01726
ATP[r] + chenodiol[r] + CoA[r] = AMP[r] + chenodeoxycholoyl-CoA[r] + PPi[r]
Left to rightBalancedEC 6.2.1.7Human-GEM MAR01727
chenodiol[c] + PAPS[c] = H+[c] + PAP[c] + sulfochenodeoxycholate[c]
Left to rightBalancedEC 2.8.2.14Human-GEM MAR01729
H2O[c] + sulfochenodeoxycholate[c] = chenodiol[c] + H+[c] + sulfate[c]
Left to rightBalancedEC 3.1.6.2Human-GEM MAR01730
cholesterol[c] + H+[c] + NADPH[c] + O2[c] = 24-hydroxycholesterol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.25Human-GEM MAR01735
24-hydroxycholesterol[c] + H+[c] + NADPH[c] + O2[c] = cholest-5-ene-3beta,7alpha,24(S)-triol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.26Human-GEM MAR01737
cholest-5-ene-3beta,7alpha,24(S)-triol[c] + NAD+[c] = 4-cholesten-7alpha,24(S)-diol-3-one[c] + H+[c] + NADH[c]
Left to rightBalancedEC 1.1.1.181Human-GEM MAR01738
4-cholesten-7alpha,24(S)-diol-3-one[c] + H+[c] + NADPH[c] + O2[c] = 4-cholesten-7alpha,12alpha,24(S)-triol-3-one[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.139Human-GEM MAR01739
4-cholesten-7alpha,12alpha,24(S)-triol-3-one[c] + H+[c] + NADPH[c] = 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.3Human-GEM MAR01740
4-cholesten-7alpha,24(S)-diol-3-one[c] + H+[c] + NADPH[c] = 5beta-cholestan-7alpha,24(S)-diol-3-one[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.3Human-GEM MAR01741
5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one[c] + H+[c] + NADPH[c] = 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.50Human-GEM MAR01742
5beta-cholestan-7alpha,24(S)-diol-3-one[c] + H+[c] + NADPH[c] = 5beta-cholestan-3alpha,7alpha,24(S)-triol[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.50Human-GEM MAR01743
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol[m] + H+[m] + NADPH[m] + O2[m] = 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01746
5beta-cholestan-3alpha,7alpha,24(S)-triol[m] + H+[m] + NADPH[m] + O2[m] = 5beta-cholestan-3alpha,7alpha,24(S),27-tetrol[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01747
5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol[m] + H+[m] + NADPH[m] + O2[m] = 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al[m] + 2 H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01748
5beta-cholestan-3alpha,7alpha,24(S),27-tetrol[m] + H+[m] + NADPH[m] + O2[m] = 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al[m] + 2 H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01749
3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al[m] + NADPH[m] + O2[m] = H2O[m] + NADP+[m] + tetraHCA[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01750
3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al[m] + NADPH[m] + O2[m] = 3,7,24THCA[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01751
ATP[c] + CoA[c] + tetraHCA[c] = 25(R)TetraHCA-CoA[c] + AMP[c] + PPi[c]
Left to rightBalancedEC 6.2.1.7Human-GEM MAR01754
3,7,24THCA[c] + ATP[c] + CoA[c] = 3,7,24THCA-CoA[c] + AMP[c] + PPi[c]
Left to rightBalancedEC 6.2.1.7Human-GEM MAR01756
25(R)TetraHCA-CoA[x] = (24R,25R)3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA[x]
Left to rightBalancedEC 5.1.99.4Human-GEM MAR01760
3,7,24THCA-CoA[x] = (24R,25R)3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA[x]
Left to rightBalancedEC 5.1.99.4Human-GEM MAR01761
cholesterol[m] + H+[m] + NADPH[m] + O2[m] = 27-hydroxycholesterol[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01762
27-hydroxycholesterol[c] + H+[c] + NADPH[c] + O2[c] = cholest-5-ene-3beta,7alpha,27-triol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.29Human-GEM MAR01765
cholest-5-ene-3beta,7alpha,27-triol[c] + NAD+[c] = 4-cholesten-7alpha,27-diol-3-one[c] + H+[c] + NADH[c]
Left to rightBalancedEC 1.1.1.181Human-GEM MAR01766
4-cholesten-7alpha,27-diol-3-one[c] + H+[c] + NADPH[c] + O2[c] = 4-cholesten-7alpha,12alpha,27-triol-3-one[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.139Human-GEM MAR01767
4-cholesten-7alpha,12alpha,27-triol-3-one[c] + H+[c] + NADPH[c] = 5beta-cholestan-7alpha,12alpha,27-triol-3-one[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.3Human-GEM MAR01768
4-cholesten-7alpha,27-diol-3-one[c] + H+[c] + NADPH[c] = 5beta-cholestan-7alpha,27-diol-3-one[c] + NADP+[c]
Left to rightBalancedEC 1.3.1.3Human-GEM MAR01769
5beta-cholestan-7alpha,12alpha,27-triol-3-one[c] + H+[c] + NADPH[c] = 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.50Human-GEM MAR01770
5beta-cholestan-7alpha,27-diol-3-one[c] + H+[c] + NADPH[c] = 5beta-cholestane-3alpha,7alpha,26-triol[c] + NADP+[c]
Left to rightBalancedEC 1.1.1.50Human-GEM MAR01771
cholesterol[r] + H+[r] + NADPH[r] + O2[r] = 25-hydroxycholesterol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.99.38Human-GEM MAR01776
25-hydroxycholesterol[r] + H+[r] + NADPH[r] + O2[r] = cholest-5-ene-3beta,7alpha,25-triol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.29Human-GEM MAR01777
7alpha,25-dihydroxy-4-cholesten-3-one[r] + H+[r] + NADH[r] = cholest-5-ene-3beta,7alpha,25-triol[r] + NAD+[r]
ReversibleBalancedEC 1.1.1.181Human-GEM MAR01778