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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
Interactions
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Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

9,901–9,950 of 18,558 reactions from Rhea

phlorisobutanophenone + dimethylallyl diphosphate = 4-prenylphlorisobutanophenone + diphosphate
Direction not assertedBalancedRhea 51772
4-prenylphlorisobutanophenone + dimethylallyl diphosphate = deoxycohumulone + diphosphate
Direction not assertedBalancedRhea 51776
4-prenylphlormethylbutanophenone + dimethylallyl diphosphate = deoxyadlupulone + diphosphate
Direction not assertedBalancedRhea 51780
4-prenylphlorisovalerophenone + dimethylallyl diphosphate = deoxyhumulone + diphosphate
Direction not assertedBalancedRhea 51784
2-hydroxybenzoyl-5'-AMP + CoA = 2-hydroxybenzoyl-CoA + AMP + H(+)
Direction not assertedBalancedRhea 51788
salicylate + NADH + O2 + H(+) = 2,3-dihydroxybenzoate + NAD(+) + H2O
Direction not assertedBalancedRhea 51792
deoxycohumulone + dimethylallyl diphosphate = colupulone + diphosphate + H(+)

Direction not assertedBalancedRhea 51796

deoxyadlupulone + dimethylallyl diphosphate = adlupulone + diphosphate + H(+)

Direction not assertedBalancedRhea 51800

deoxyhumulone + dimethylallyl diphosphate = lupulone + diphosphate + H(+)

Direction not assertedBalancedRhea 51804

(9Z)-octadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-octadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 51808

tetradecanoate(out) + ATP(in) + CoA(in) + H(+)(out) = tetradecanoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 51812

dodecanoate(out) + ATP(in) + CoA(in) + H(+)(out) = dodecanoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 51816

decanoate(out) + ATP(in) + CoA(in) + H(+)(out) = decanoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 51820

octanoate(out) + ATP(in) + CoA(in) + H(+)(out) = octanoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 51824

docosanoate(out) + ATP(in) + CoA(in) + H(+)(out) = docosanoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 51828

tetracosanoate(out) + ATP(in) + CoA(in) + H(+)(out) = tetracosanoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 51832

(9Z)-tetradecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-tetradecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 51836

tauroallocholate(out) + 2 Na(+)(out) = tauroallocholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 51840

(9Z)-hexadecenoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 51844

8-methylmenaquinone-6 + succinate = 8-methylmenaquinol-6 + fumarate

Direction not assertedBalancedRhea 51848

(9Z,12Z)-octadecadienoate(out) + ATP(in) + CoA(in) + H(+)(out) = (9Z,12Z)-octadecadienoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 51852

(E)-hexadec-2-enoate(out) + ATP(in) + CoA(in) + H(+)(out) = (2E)-hexadecenoyl-CoA(in) + AMP(in) + diphosphate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 51856

umbelliferone + (2E)-geranyl diphosphate = 8-geranylumbelliferone + diphosphate

Direction not assertedBalancedRhea 51860

esculetin + (2E)-geranyl diphosphate = 8-geranylesculetin + diphosphate

Direction not assertedBalancedRhea 51864

umbelliferone + dimethylallyl diphosphate = demethylsuberosin + diphosphate

Direction not assertedBalancedRhea 51868

umbelliferone + dimethylallyl diphosphate = osthenol + diphosphate

Direction not assertedBalancedRhea 51872

2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate = desmethylxanthohumol + diphosphate

Direction not assertedBalancedRhea 51876

3,4,6-trichlorocatechol + O2 = (2Z,4E)-2,3,5-trichloromuconate + H(+)

Direction not assertedBalancedRhea 51880

L-proline betaine = D-proline betaine

Direction not assertedBalancedRhea 51884

2,3,5,6-tetrachlorohydroquinone + NAD(+) + H(+) = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH

Direction not assertedBalancedRhea 51888

N-acetylcadaverine + H2O = cadaverine + acetate

Direction not assertedBalancedRhea 51892

N(1)-acetylspermine + H2O = spermine + acetate

Direction not assertedBalancedRhea 51896

N(1)-acetylspermidine + H2O = spermidine + acetate

Direction not assertedBalancedRhea 51900

10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 51904

dATP + H2O = dADP + phosphate + H(+)

Left to rightBalancedRhea 51908

(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 51912

(2S)-2-amino-3-butenoate + H2O = 2-oxobutanoate + NH4(+)

Direction not assertedBalancedRhea 51916

a quinone + AH2 = a quinol + A

Direction not assertedBalance undeterminableRhea 51920

menaquinone-9 + AH2 = beta-dihydromenaquinone-9 + A

Direction not assertedBalancedRhea 51924

N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) + H2O = (S)-2,3-diaminopropanoate + 2-oxoglutarate + NADH + H(+)

Direction not assertedBalancedRhea 51928

2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite = 2 Fe(II)-[cytochrome c3] + thiosulfate

Direction not assertedBalance undeterminableRhea 51932

2-(glutathione-S-yl)-hydroquinone + glutathione = hydroquinone + glutathione disulfide

Direction not assertedBalancedRhea 51936

(1E,2S)-2-methylbutanal oxime = (1Z,2S)-2-methylbutanal oxime

Direction not assertedBalancedRhea 51940

8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine = roseoflavin + 2 S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalancedRhea 51944

(2S)-2-methylbutanenitrile + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxy-2-methylbutanenitrile + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 51948

(E)-2-methylpropanal oxime + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxy-2-methylpropanenitrile + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 51952

(E)-2-methylpropanal oxime = (Z)-2-methylpropanal oxime

Direction not assertedBalancedRhea 51956

(Z)-2-methylpropanal oxime = 2-methylpropanenitrile + H2O

Direction not assertedBalancedRhea 51960

2-methylpropanenitrile + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxy-2-methylpropanenitrile + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 51964

(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate

Left to rightBalancedRhea 51968

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