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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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Reference

Evidence

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Reach

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Organisms
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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

9,651–9,700 of 18,558 reactions from Rhea

4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine = anhydrotetracycline + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 50768
nitroethane + O2 + H2O = acetaldehyde + nitrite + H2O2 + H(+)
Direction not assertedBalancedRhea 50772
hexanal + NADP(+) = (E)-hex-2-enal + NADPH + H(+)
Right to leftBalancedRhea 50776
octanal + NADP(+) = (2E)-octenal + NADPH + H(+)
Right to leftBalancedRhea 50780
dodecanal + NADP(+) = (2E)-dodecenal + NADPH + H(+)
Right to leftBalancedRhea 50784
pentan-2-one + NADP(+) = (E)-pent-3-en-2-one + NADPH + H(+)
Right to leftBalancedRhea 50788
18-hydroxycorticosterone + 2 reduced [adrenodoxin] + O2 + 2 H(+) = aldosterone + 2 oxidized [adrenodoxin] + 2 H2O

Left to rightBalance undeterminableRhea 50792

prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

Left to rightBalancedRhea 50796

prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

Left to rightBalancedRhea 50800

prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione

Left to rightBalancedRhea 50804

prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione

Left to rightBalancedRhea 50808

androst-4-ene-3,17-dione + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 1alpha-hydroxyandrost-4-ene-3,17-dione + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 50812

androst-4-ene-3,17-dione + NADPH + H(+) = 5alpha-androstan-3,17-dione + NADP(+)

ReversibleBalancedRhea 50816

17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = testosterone + NADPH + H(+)

Right to leftBalancedRhea 50820

(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = 14-hydroperoxy-(4Z,7Z,10Z,12E,16Z)-docosapentaenoate

Left to rightBalancedRhea 50824

(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E)-docosapentaenoate

Direction not assertedBalancedRhea 50828

(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 17-hydroperoxy-(7Z,10Z,13Z,15E,19Z)-docosapentaenoate

Direction not assertedBalancedRhea 50832

(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + O2 = 14-hydroperoxy-(7Z,10Z,12E,16Z,19Z)-docosapentaenoate

Left to rightBalancedRhea 50836

(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate

Left to rightBalancedRhea 50840

(5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O

Left to rightBalancedRhea 50844

(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z,17Z)-eicosapentaenoate + A + H2O

Left to rightBalancedRhea 50848

(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O

Left to rightBalancedRhea 50852

(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

Left to rightBalancedRhea 50856

(9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O

Left to rightBalancedRhea 50860

(9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O

Left to rightBalancedRhea 50864

(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5,12,18R)-trihydroxy-(6Z,8E,10E,14Z,16E)-eicosapentaenoate

Direction not assertedBalancedRhea 50868

(15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + O2 = (5,6,15R)-trihydroxy-(7E,9E,11Z,13E,17Z)-eicosapentaenoate

Direction not assertedBalancedRhea 50872

a hydroperoxy polyunsaturated fatty acid + NADPH + H(+) = a hydroxy polyunsaturated fatty acid + NADP(+) + H2O

Direction not assertedBalance undeterminableRhea 50876

4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol = 4-O-[di(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)

Direction not assertedBalancedRhea 50880

(9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphate

Left to rightBalancedRhea 50884

an N-acylsphingoid base 1-phosphate + H2O = an N-acyl-sphingoid base + phosphate

Direction not assertedBalance undeterminableRhea 50888

a menaquinone + hydrogen sulfide + sulfite + 2 H(+) = a menaquinol + thiosulfate

Direction not assertedBalance undeterminableRhea 50892

8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O = (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate

Left to rightBalancedRhea 50896

10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O = (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate

Left to rightBalancedRhea 50900

L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 50904

a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O

Direction not assertedBalance undeterminableRhea 50908

4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-L-ribitol = 4-O-[1-D-ribitylphospho-(2R)-1-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)

Direction not assertedBalancedRhea 50912

a carboxylate + ATP + NADPH + H(+) = an aldehyde + AMP + diphosphate + NADP(+)

Direction not assertedBalance undeterminableRhea 50916

2 2-iminio-3-(indol-3-yl)propanoate + H2O2 = chromopyrrolate + NH4(+) + 2 H2O + H(+)

Direction not assertedBalancedRhea 50920

(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

Left to rightBalancedRhea 50924

(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

Left to rightBalancedRhea 50928

(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

Left to rightBalancedRhea 50932

(3S)-3-aminobutanoyl-CoA + 2-oxoglutarate = acetoacetyl-CoA + L-glutamate

Direction not assertedBalancedRhea 50936

L-phenylalanyl-tRNA(Phe) + L-leucyl-tRNA(Leu) = cyclo(L-phenylalanyl-L-leucyl) + tRNA(Phe) + tRNA(Leu) + H(+)

Direction not assertedBalance undeterminableRhea 50940

3-phenylpropanoate + NAD(+) = (E)-cinnamate + NADH + H(+)

Direction not assertedBalancedRhea 50944

a 2'-deoxycytidine in single-stranded DNA + H2O + H(+) = a 2'-deoxyuridine in single-stranded DNA + NH4(+)

Direction not assertedBalance undeterminableRhea 50948

7-chloro-L-tryptophan + AH2 + O2 = monodechloroaminopyrrolnitrin + A + CO2 + 2 H2O

Direction not assertedBalancedRhea 50952

cytidine(32) in tRNA(Ser) + S-adenosyl-L-methionine = N(3)-methylcytidine(32) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 50956

cytidine(32) in tRNA(Thr) + S-adenosyl-L-methionine = N(3)-methylcytidine(32) in tRNA(Thr) + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 50960

cytidine(8) in tRNA + H2O + H(+) = uridine(8) in tRNA + NH4(+)

Direction not assertedBalancedRhea 50964

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