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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

9,601–9,650 of 18,558 reactions from Rhea

N-terminal L-methionyl-L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] + CoA + H(+)
Direction not assertedBalance undeterminableRhea 50564
N-terminal L-methionyl-L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] + CoA + H(+)
Direction not assertedBalance undeterminableRhea 50568
N-terminal L-methionyl-L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] + CoA + H(+)
Direction not assertedBalance undeterminableRhea 50572
N-terminal L-methionyl-L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] + CoA + H(+)
Direction not assertedBalance undeterminableRhea 50576
N-terminal L-methionyl-L-lysyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] + CoA + H(+)
Direction not assertedBalance undeterminableRhea 50580
13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)

← Right to left

Balanced

Rhea 50584

13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)

Right to leftBalancedRhea 50588

13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)

Right to leftBalancedRhea 50592

N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50596

N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50600

N-terminal L-methionyl-[transmembrane protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50604

leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)

Left to rightBalancedRhea 50608

decanal + NADP(+) = (2E)-decenal + NADPH + H(+)

Right to leftBalancedRhea 50612

nonan-2-one + NADP(+) = (3E)-nonen-2-one + NADPH + H(+)

Right to leftBalancedRhea 50616

N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP + H(+)

Direction not assertedBalancedRhea 50620

an omega-(methylsulfanyl)-2-oxoalkanoate + acetyl-CoA + H2O = a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50624

a 2-(omega-methylsulfanyl)alkylmalate = a 3-(omega-methylsulfanyl)alkylmalate

Direction not assertedBalance undeterminableRhea 50628

a 2-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O

Direction not assertedBalance undeterminableRhea 50632

a 3-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O

Direction not assertedBalance undeterminableRhea 50636

2-(2-methylsulfanyl)ethylmalate = 3-(2-methylsulfanyl)ethylmalate

Direction not assertedBalancedRhea 50640

2-(3-methylsulfanyl)propylmalate = 3-(3-methylsulfanyl)propylmalate

Direction not assertedBalancedRhea 50644

2-(2-methylsulfanyl)ethylmalate = 2-(2-methylsulfanyl)ethylmaleate + H2O

Direction not assertedBalancedRhea 50648

2-(3-methylsulfanyl)propylmalate = 2-(2-methylsulfanyl)propylmaleate + H2O

Direction not assertedBalancedRhea 50652

3-(2-methylsulfanyl)ethylmalate = 2-(2-methylsulfanyl)ethylmaleate + H2O

Direction not assertedBalancedRhea 50656

3-(3-methylsulfanyl)propylmalate = 2-(2-methylsulfanyl)propylmaleate + H2O

Direction not assertedBalancedRhea 50660

a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->3)-beta-D-GlcNAc derivative + GDP + H(+)

Left to rightBalance undeterminableRhea 50664

a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + GDP-beta-L-fucose = an alpha-L-Fuc-(1->2)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP + H(+)

Left to rightBalance undeterminableRhea 50668

[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + H2O = [(1->4)-N-acetyl-beta-D-glucosaminyl](n-2) + N,N'-diacetylchitobiose

Direction not assertedBalance undeterminableRhea 50672

N-terminal L-asparaginyl-[protein] + H2O + H(+) = N-terminal L-aspartyl-[protein] + NH4(+)

Direction not assertedBalance undeterminableRhea 50676

N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH4(+)

Direction not assertedBalance undeterminableRhea 50680

N(5)-phenyl-L-glutamine + H2O = aniline + L-glutamate + H(+)

Direction not assertedBalancedRhea 50684

ADP-alpha-D-glucose + alpha-D-glucose 1-phosphate = alpha-maltose 1-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 50692

calciol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = calcidiol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 50696

calcidiol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = calcitriol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 50700

1-propanol + NAD(+) = propanal + NADH + H(+)

Direction not assertedBalancedRhea 50704

(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

Left to rightBalancedRhea 50708

tetracycline + FADH2 + chloride + O2 = 7-chlorotetracycline + FAD + 2 H2O + H(+)

Direction not assertedBalancedRhea 50712

dimethyl sulfone + FMNH2 + O2 = methanesulfinate + FMN + formaldehyde + H2O + 2 H(+)

Direction not assertedBalancedRhea 50716

methanesulfinate + FMNH2 + O2 = methanesulfonate + FMN + H2O + H(+)

Direction not assertedBalancedRhea 50720

(E)-4-hydroxyphenylacetaldehyde oxime = (Z)-(4-hydroxyphenyl)acetaldehyde oxime

Direction not assertedBalancedRhea 50724

(Z)-(4-hydroxyphenyl)acetaldehyde oxime = 4-hydroxyphenylacetonitrile + H2O

Direction not assertedBalancedRhea 50728

4-hydroxyphenylacetonitrile + reduced [NADPH--hemoprotein reductase] + O2 = (S)-4-hydroxymandelonitrile + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 50732

a quinone + hydrogen sulfide + sulfite + 2 H(+) = thiosulfate + a quinol

Direction not assertedBalance undeterminableRhea 50736

leukotriene C4 + H2O = leukotriene F4 + glycine

Left to rightBalancedRhea 50740

2 glyphosate + O2 = 2 aminomethylphosphonate + 2 glyoxylate + 2 H(+)

Direction not assertedBalancedRhea 50744

juglone + H2O = naphthalene-1,2,4,8-tetrol

Direction not assertedBalancedRhea 50748

2 naphthalene-1,2,4,8-tetrol + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H2O + 2 H(+)

Direction not assertedBalancedRhea 50752

reduced [flavodoxin] + NADP(+) = oxidized [flavodoxin] + NADPH + 2 H(+)

Direction not assertedBalance undeterminableRhea 50756

a quinone + sulfite + H2O = a quinol + sulfate

Direction not assertedBalance undeterminableRhea 50760

4-amino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-methionine = 4-methylamino-4-dedimethylamino-anhydrotetracycline + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 50764

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