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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
Interactions
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Reactions
Reach

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Organisms
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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

9,551–9,600 of 18,558 reactions from Rhea

(S)-scoulerine + reduced [NADPH--hemoprotein reductase] + O2 = (S)-nandinine + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)
Direction not assertedBalance undeterminableRhea 50364
2-methylbutan-2-ol + NADPH + O2 + H(+) = 3-hydroxy-3-methylbut-1-ene + NADP(+) + 2 H2O
Direction not assertedBalancedRhea 50368
an N-acylsphingoid base 1-phosphate(in) = an N-acylsphingoid base 1-phosphate(out)
Direction not assertedBalance undeterminableTransportRhea 50372
a ceramide(in) + ATP + H2O = a ceramide(out) + ADP + phosphate + H(+)
Direction not assertedBalance undeterminableTransportRhea 50376
3 malonyl-CoA + 3 H(+) = 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA
Direction not assertedBalancedRhea 50380
tetracycline + oxidized coenzyme F420-(gamma-L-Glu)(n) + H(+) = 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)
Direction not asserted

Balance undeterminable

Rhea 50384

5a,11a-dehydrotetracycline + NADPH + O2 + H(+) = 5a,11a-dehydrooxytetracycline + NADP(+) + H2O

Direction not assertedBalancedRhea 50388

oxytetracycline + oxidized coenzyme F420-(gamma-L-Glu)(n) + H(+) = 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)

Direction not assertedBalance undeterminableRhea 50392

(2-aminobenzoyl)acetate + octanoyl-CoA + H(+) = 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O

Direction not assertedBalancedRhea 50396

L-cysteinyl-[PqsC protein] + octanoyl-CoA = S-octanoyl-L-cysteinyl-[PqsC protein] + CoA

Direction not assertedBalance undeterminableRhea 50400

S-octanoyl-L-cysteinyl-[PqsC protein] + (2-aminobenzoyl)acetate + H(+) = L-cysteinyl-[PqsC protein] + 1-(2-aminophenyl)decane-1,3-dione + CO2

Direction not assertedBalance undeterminableRhea 50404

1-(2-aminophenyl)decane-1,3-dione = 2-heptyl-4(1H)-quinolone + H2O

Direction not assertedBalancedRhea 50408

N-terminal L-glutamyl-[protein] + L-leucyl-tRNA(Leu) = N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu) + H(+)

Direction not assertedBalance undeterminableRhea 50412

N-terminal L-arginyl-[protein] + L-leucyl-tRNA(Leu) = N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu) + H(+)

Direction not assertedBalance undeterminableRhea 50416

N-terminal L-aspartyl-[protein] + L-leucyl-tRNA(Leu) = N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu) + H(+)

Direction not assertedBalance undeterminableRhea 50420

(8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1

Left to rightBalancedRhea 50424

methanethiol + S-adenosyl-L-methionine = dimethyl sulfide + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 50428

prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O

Left to rightBalancedRhea 50432

prostaglandin H1 = prostaglandin E1

Direction not assertedBalancedRhea 50436

prostaglandin H1 = prostaglandin D1

Direction not assertedBalancedRhea 50440

(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 = prostaglandin G3

Left to rightBalancedRhea 50444

prostaglandin G3 + AH2 = prostaglandin H3 + A + H2O

Left to rightBalancedRhea 50448

prostaglandin H3 = prostaglandin E3

Direction not assertedBalancedRhea 50452

prostaglandin H3 = prostaglandin D3

Direction not assertedBalancedRhea 50456

a medium-chain fatty acid + holo-[ACP] + ATP = a medium-chain fatty acyl-[ACP] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 50460

4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 8 malonyl-CoA + 16 NADPH + 24 H(+) = 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 16 NADP(+) + 8 CoA + 8 H2O

Direction not assertedBalance undeterminableRhea 50464

4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 9 malonyl-CoA + 18 NADPH + 27 H(+) = 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 18 NADP(+) + 9 CoA + 9 H2O

Direction not assertedBalance undeterminableRhea 50468

anthraniloyl-CoA + malonyl-CoA + H(+) = (2-aminobenzoyl)acetyl-CoA + CO2 + CoA

Direction not assertedBalancedRhea 50472

L-cysteinyl-[PqsD protein] + anthraniloyl-CoA = S-anthraniloyl-L-cysteinyl-[PqsD protein] + CoA

Direction not assertedBalance undeterminableRhea 50476

N-terminal L-methionyl-L-aspartyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50480

N-terminal L-methionyl-L-asparaginyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50484

N-terminal L-methionyl-L-glutamyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50488

N-terminal L-methionyl-L-glutaminyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50492

N-terminal glycyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetylglycyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50496

N-terminal L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-alanyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50500

N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50504

N-terminal L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-valyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50508

N-terminal L-cysteinyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50512

N-terminal L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-threonyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50516

N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50520

N-terminal L-methionyl-L-isoleucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50524

N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50528

N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50532

prostaglandin E2 = prostaglandin A2 + H2O

Direction not assertedBalancedRhea 50536

prostaglandin A2 = prostaglandin C2

Direction not assertedBalancedRhea 50540

prostaglandin C2 = prostaglandin B2

Direction not assertedBalancedRhea 50544

prostaglandin E1 = prostaglandin A1 + H2O

Direction not assertedBalancedRhea 50548

prostaglandin C1 = prostaglandin B1

Direction not assertedBalancedRhea 50552

prostaglandin D2 = prostaglandin J2 + H2O

Direction not assertedBalancedRhea 50556

N-terminal L-methionyl-L-tryptophyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50560

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