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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

901–950 of 18,558 reactions from Rhea

a di-trans,poly-cis-dolichyl phosphate + H2O = a di-trans,poly-cis-dolichol + phosphate
Direction not assertedBalance undeterminableRhea 13797
hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)
Direction not assertedBalancedRhea 13801
a 3-oxo-5alpha-steroid + A = a 3-oxo-Delta(4)-steroid + AH2
Direction not assertedBalance undeterminableRhea 13805
aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate
Direction not assertedBalancedRhea 13809
benzene + NADH + O2 + H(+) = cis-1,2-dihydrobenzene-1,2-diol + NAD(+)
Direction not assertedBalancedRhea 13813
phylloquinone + [protein]-disulfide + H2O = 2,3-epoxyphylloquinone + [protein]-dithiol
Right to leftBalance undeterminableRhea 13817
glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2

Direction not assertedBalancedRhea 13821

GDP-alpha-D-rhamnose + NAD(+) = GDP-4-dehydro-alpha-D-rhamnose + NADH + H(+)

Direction not assertedBalancedRhea 13825

GDP-alpha-D-rhamnose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + NADPH + H(+)

Direction not assertedBalancedRhea 13829

L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine

Direction not assertedBalancedRhea 13833

cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) = 4,5-dihydroxyphthalate + NADH + H(+)

Direction not assertedBalancedRhea 13837

Fe(II)2-[transferrin] + NAD(+) + H(+) = Fe(III)2-[transferrin] + NADH

Direction not assertedBalance undeterminableRhea 13841

dihydroxyfumarate + H(+) = 2-hydroxy-3-oxopropanoate + CO2

Direction not assertedBalancedRhea 13845

D-arabinose = D-ribulose

Direction not assertedBalancedRhea 13849

4-methylene-L-glutamate + NH4(+) + ATP = 4-methylene-L-glutamine + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 13853

a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + D-glucose + H(+)

Direction not assertedBalance undeterminableRhea 13857

D-xylose + NAD(+) = D-xylono-1,5-lactone + NADH + H(+)

Direction not assertedBalancedRhea 13861

an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = a beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)

Left to rightBalance undeterminableRhea 13865

prephenate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH

Direction not assertedBalancedRhea 13869

(+)-copalyl diphosphate = abieta-7,13-diene + diphosphate

Direction not assertedBalancedRhea 13873

a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid

Direction not assertedBalance undeterminableRhea 13877

an aldehyde + a quinone + H2O = a quinol + a carboxylate + H(+)

Direction not assertedBalance undeterminableRhea 13881

stipitatonate + H2O = stipitatate + CO2

Direction not assertedBalancedRhea 13885

FAD + H2O = FMN + AMP + 2 H(+)

Left to rightBalancedRhea 13889

P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)

Left to rightBalancedRhea 13893

chorismate = prephenate

Direction not assertedBalancedRhea 13897

N-(aminomethyl)urea + H2O = N-(hydroxymethyl)urea + NH4(+)

Direction not assertedBalancedRhea 13901

a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)

Left to rightBalance undeterminableRhea 13905

urate D-ribonucleoside + phosphate = alpha-D-ribose 1-phosphate + urate

Direction not assertedBalancedRhea 13909

L-threonine = D-threonine

Direction not assertedBalancedRhea 13913

(-)-menthol + NADP(+) = (1R,4S)-menthone + NADPH + H(+)

Direction not assertedBalancedRhea 13917

ent-kaur-16-en-19-oate + 4 reduced [2Fe-2S]-[ferredoxin] + 2 O2 + 4 H(+) = gibberellin A12 aldehyde + 4 oxidized [2Fe-2S]-[ferredoxin] + 3 H2O

Direction not assertedBalance undeterminableRhea 13921

(3R)-hydroxytetradecanoyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]

Direction not assertedBalance undeterminableRhea 13925

agmatine + H2O = urea + putrescine

Direction not assertedBalancedRhea 13929

all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)

Left to rightBalancedRhea 13933

4-sulfobenzoate + NADH + O2 = 3,4-dihydroxybenzoate + sulfite + NAD(+)

Direction not assertedBalancedRhea 13937

D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 13941

(S)-mandelate = (R)-mandelate

Direction not assertedBalancedRhea 13945

2 reduced [rubredoxin] + NADP(+) + H(+) = 2 oxidized [rubredoxin] + NADPH

Direction not assertedBalance undeterminableRhea 13949

a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)

Direction not assertedBalance undeterminableRhea 13953

4 sulfur + O2 + 4 H2O = 2 hydrogen sulfide + 2 sulfite + 6 H(+)

Direction not assertedBalancedRhea 13957

protoporphyrin IX + Mg(2+) + ATP + H2O = Mg-protoporphyrin IX + ADP + phosphate + 3 H(+)

Direction not assertedBalancedRhea 13961

L,L-cystathionine + H2O = L-homocysteine + pyruvate + NH4(+)

Direction not assertedBalancedRhea 13965

a 3'-end 3'-phospho-ribonucleotide-RNA + GTP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + GMP + diphosphate

Direction not assertedBalance undeterminableRhea 13969

diphosphate + H2O + H(+)(in) = 2 phosphate + 2 H(+)(out)

Direction not assertedBalancedTransportRhea 13973

D-serine = pyruvate + NH4(+)

Direction not assertedBalancedRhea 13977

L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)

Direction not assertedBalancedRhea 13985

alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Direction not assertedBalancedRhea 13989

(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate

Left to rightBalancedRhea 13993

3-methyl-2-oxobutanoate + NAD(+) + CoA = 2-methylpropanoyl-CoA + CO2 + NADH

Direction not assertedBalancedRhea 13997

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