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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
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PathwaysReactions grouped under one name
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Reference

Evidence

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

9,351–9,400 of 18,558 reactions from Rhea

L-1-piperideine-6-carboxylate + NADP(+) + 2 H2O = L-2-aminoadipate + NADPH + H(+)
Direction not assertedBalancedRhea 49480
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(in) + ATP + H2O = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine(out) + ADP + phosphate + H(+)
Direction not assertedBalancedTransportRhea 49484
GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + 2-oxoglutarate + NH4(+)
Direction not assertedBalancedRhea 49488
GDP-4-dehydro-alpha-D-rhamnose + L-glutamate = 2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + 2-oxoglutarate + H2O + H(+)
Direction not assertedBalancedRhea 49492
2-GDP-(2S,3S,6R)-3-hydroxy-5-amino-6-methyl-3,6-dihydro-2H-pyran + H(+) = 2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane
Direction not assertedBalancedRhea 49496
2-GDP-(2S,3S,6R)-3-hydroxy-5-imino-6-methyloxane + H2O = GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NH4(+)
Direction not asserted

?

Balanced

Rhea 49500

phosphinomethylmalate = phosphinomethylisomalate

Direction not assertedBalancedRhea 49504

phosphinomethylmalate = 2-(phosphinatomethylidene)butanedioate + H2O

Direction not assertedBalancedRhea 49508

2-(phosphinatomethylidene)butanedioate + H2O = phosphinomethylisomalate

Direction not assertedBalancedRhea 49512

an N(1)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2

Direction not assertedBalance undeterminableRhea 49516

an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2

Left to rightBalance undeterminableRhea 49520

an N(6)-methyl-2'-deoxyadenosine in DNA + 2-oxoglutarate + O2 = a 2'-deoxyadenosine in DNA + formaldehyde + succinate + CO2

Left to rightBalance undeterminableRhea 49524

(ethylene terephthalate)(n) + H2O = (ethylene terephthalate)(n-1) + 4-[(2-hydroxyethoxy)carbonyl]benzoate + H(+)

Direction not assertedBalance undeterminableRhea 49528

4-[(2-hydroxyethoxy)carbonyl]benzoate + H2O = terephthalate + ethylene glycol + H(+)

Direction not assertedBalancedRhea 49532

2-amino-2-deoxy-D-gluconate = (2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate + H2O

Direction not assertedBalancedRhea 49536

(2Z,4S,5R)-2-amino-4,5,6-trihydroxyhex-2-enoate = (4S,5R)-4,5,6-trihydroxy-2-iminohexanoate

Direction not assertedBalancedRhea 49540

(4S,5R)-4,5,6-trihydroxy-2-iminohexanoate + H2O = 2-dehydro-3-deoxy-D-gluconate + NH4(+)

Direction not assertedBalancedRhea 49544

N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein] + H2O = lactate + L-arginyl-[protein] + H(+)

Direction not assertedBalance undeterminableRhea 49548

N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein] + H2O = lactate + L-lysyl-[protein] + H(+)

Direction not assertedBalance undeterminableRhea 49552

S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] + H2O = lactate + L-cysteinyl-[protein] + H(+)

Direction not assertedBalance undeterminableRhea 49556

D-sedoheptulose 7-phosphate = (R)-demethyl-4-deoxygadusol + phosphate + H2O + H(+)

Direction not assertedBalancedRhea 49560

D-sedoheptulose 7-phosphate = 2-epi-valiolone + phosphate

Direction not assertedBalancedRhea 49564

2-glutathionyl-2-methylbut-3-en-1-ol = (3R)-3,4-epoxy-3-methylbut-1-ene + glutathione

Direction not assertedBalancedRhea 49568

Fe-coproporphyrin III + 2 H(+) = coproporphyrin III + Fe(2+)

Direction not assertedBalancedRhea 49572

GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)

Direction not assertedBalancedRhea 49576

(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate

Direction not assertedBalancedRhea 49580

D-erythrulose 1-phosphate = L-erythrulose 1-phosphate

Direction not assertedBalancedRhea 49584

L-erythrulose 1-phosphate = D-erythrulose 4-phosphate

Direction not assertedBalancedRhea 49588

2-hydroxyisobutanoyl-CoA = (3S)-3-hydroxybutanoyl-CoA

Direction not assertedBalancedRhea 49592

an N-acylsphing-4-enine + UDP-alpha-D-galactose = N-acyl-D-galactosylsphing-4-enine + UDP + H(+)

Direction not assertedBalance undeterminableRhea 49596

octanedioate + ATP + CoA = octanedioyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 49600

2-glutathionyl-2-methylbut-3-en-1-ol + NAD(+) = 2-glutathionyl-2-methylbut-3-enal + NADH + H(+)

Direction not assertedBalancedRhea 49604

2-glutathionyl-2-methylbut-3-enal + NAD(+) + H2O = 2-glutathionyl-2-methylbut-3-enoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 49608

(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)

Direction not assertedBalancedRhea 49612

2-hydroxy-2-methylpropanal + NAD(+) + H2O = 2-hydroxy-2-methylpropanoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 49616

D-erythritol 1-phosphate + NADP(+) = D-erythrulose 1-phosphate + NADPH + H(+)

Direction not assertedBalancedRhea 49620

erythritol + ATP = D-erythritol 1-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 49624

3 malonyl-CoA + acetyl-CoA + 2 S-adenosyl-L-methionine = 3,5-dimethylorsellinate + 2 S-adenosyl-L-homocysteine + 3 CO2 + 4 CoA

Direction not assertedBalancedRhea 49628

3,5-dimethylorsellinate + (2E,6E)-farnesyl diphosphate = (3R)-3-farnesyl-6-hydroxy-2,3,5-trimethyl-4-oxocyclohexa-1,5-diene-1-carboxylate + diphosphate + H(+)

Direction not assertedBalancedRhea 49632

methylglyoxal + O2 + H2O = pyruvate + H2O2 + H(+)

Direction not assertedBalancedRhea 49636

protoviolaceinate + NADH + O2 + H(+) = violaceinate + NAD(+) + H2O

Direction not assertedBalancedRhea 49652

protodeoxyviolaceinate + NADH + O2 + H(+) = deoxyviolaceinate + NAD(+) + H2O

Direction not assertedBalancedRhea 49668

L-methionyl(47)-[F-actin] + NADPH + O2 + H(+) = L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+) + H2O

Direction not assertedBalance undeterminableRhea 49676

resorcinol + NADH + O2 + H(+) = benzene-1,2,4-triol + NAD(+) + H2O

Direction not assertedBalancedRhea 49684

nocardicin G + S-adenosyl-L-methionine = isonocardicin C + S-methyl-5'-thioadenosine + H(+)

Direction not assertedBalancedRhea 49708

3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + NADH + O2 + H(+) = 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + NAD(+) + H2O

Direction not assertedBalance undeterminableRhea 49716

protoviolaceinate + NADH + 2 O2 + 2 H(+) = violacein + CO2 + NAD(+) + 2 H2O

Direction not assertedBalancedRhea 49720

protoviolaceinate + NADPH + 2 O2 + 2 H(+) = violacein + CO2 + NADP(+) + 2 H2O

Direction not assertedBalancedRhea 49728

violaceinate + O2 + H(+) = violacein + CO2 + H2O

Direction not assertedBalancedRhea 49732

protodeoxyviolaceinate + NADH + 2 O2 + 2 H(+) = deoxyviolacein + CO2 + NAD(+) + 2 H2O

Direction not assertedBalancedRhea 49736

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