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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

9,151–9,200 of 18,558 reactions from Rhea

20-oxo-leukotriene B4 + reduced [NADPH--hemoprotein reductase] + O2 = 20-carboxy-leukotriene B4 + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)
Left to rightBalance undeterminableRhea 48672
6-trans-leukotriene B4 + reduced [NADPH--hemoprotein reductase] + O2 = 20-hydroxy-6-trans-leukotriene B4 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Left to rightBalance undeterminableRhea 48676
a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)
Direction not assertedBalance undeterminableRhea 48680
[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine
Direction not assertedBalance undeterminableRhea 48684
N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-meso-2,6-diaminoheptanedioyl-D-alanine + H2O = N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-meso-2,6-diaminoheptanedioate + D-alanine
Direction not assertedBalancedRhea 48688
1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + octanoate + H(+)

Left to rightBalancedRhea 48692

1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = octanoyl-3-(beta-D-galactosyl)-sn-glycerol + octanoate + H(+)

Left to rightBalancedRhea 48696

long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = long chain acyl-3-O-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 48700

(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate

Left to rightBalancedRhea 48704

long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 48708

2 Fe(2+) + H2O2 + 2 H(+) = 2 Fe(3+) + 2 H2O

Direction not assertedBalancedRhea 48712

(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O

Left to rightBalancedRhea 48716

aurachin B + NAD(+) + H2O = 4-hydroxy-2-methyl-3-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH

Direction not assertedBalancedRhea 48720

aurachin B + H2O + H(+) = 3,4-dihydroxy-2-methyl-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide

Direction not assertedBalancedRhea 48724

3,4-dihydroxy-2-methyl-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) = 4-hydroxy-2-methyl-3-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH + H(+)

Direction not assertedBalancedRhea 48728

[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O = [CysO sulfur-carrier protein]-C-terminal Gly-Gly + L-cysteine + H(+)

Direction not assertedBalance undeterminableRhea 48732

(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 48736

[CysO sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + O-phospho-L-serine + H(+) = [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate

Direction not assertedBalance undeterminableRhea 48740

(-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + succinate + CO2 + H2O

Direction not assertedBalancedRhea 48744

D-threitol + NAD(+) = D-erythrulose + NADH + H(+)

Direction not assertedBalancedRhea 48748

validamycin A + 2-oxoglutarate + O2 = validamycin B + succinate + CO2 + H(+)

Direction not assertedBalancedRhea 48752

erythritol + NAD(+) = D-erythrulose + NADH + H(+)

Direction not assertedBalancedRhea 48756

L-threitol + NAD(+) = L-erythrulose + NADH + H(+)

Direction not assertedBalancedRhea 48760

3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD(+) = 3-acetyl-3-devinylchlorophyllide a + NADH + H(+)

Direction not assertedBalancedRhea 48764

D-erythrulose + ATP = D-erythrulose 4-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 48768

3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a = 3-deacetyl-3-vinylbacteriochlorophyllide a + H2O

Direction not assertedBalancedRhea 48772

prostaglandin H2 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxyprostaglandin H2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 48776

L-erythrulose + ATP = L-erythrulose 1-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 48780

D-erythrulose 4-phosphate = D-erythrose 4-phosphate

Direction not assertedBalancedRhea 48784

Lc4Cer + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + GDP + H(+)

Left to rightBalance undeterminableRhea 48792

prostaglandin H1 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxyprostaglandin H1 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 48796

a neolactoside nLc4Cer + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer + GDP + H(+)

Left to rightBalance undeterminableRhea 48800

(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O

Left to rightBalancedRhea 48804

(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O

Left to rightBalancedRhea 48808

(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O

Left to rightBalancedRhea 48812

(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 17R-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + A + H2O

Left to rightBalancedRhea 48816

(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + AH2 + O2 = 13-hydroxy-(4Z,7Z,10Z,14E,16Z,19Z)-docosahexaenoate + A + H2O

Left to rightBalancedRhea 48820

Lc4Cer + GDP-beta-L-fucose = a lactoside III(4)-a-Fuc-Lc4Cer + GDP + H(+)

Left to rightBalance undeterminableRhea 48824

resorcinol + NADPH + O2 + H(+) = benzene-1,2,4-triol + NADP(+) + H2O

Direction not assertedBalancedRhea 48828

(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

Left to rightBalancedRhea 48832

(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O

Left to rightBalancedRhea 48836

(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O

Left to rightBalancedRhea 48840

(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

Left to rightBalancedRhea 48844

(9Z,12Z)-octadecadienoate + O2 = 13-hydroperoxy-(9Z,11E)-octadecadienoate

Left to rightBalancedRhea 48848

(7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 = 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O

Left to rightBalancedRhea 48852

(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O

Left to rightBalancedRhea 48856

18-HEPE + O2 = (5S)-hydroperoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate

Left to rightBalancedRhea 48860

2-methylpropan-1-amine + FADH2 + O2 = N-(2-methylpropyl)hydroxylamine + FAD + H2O + 2 H(+)

Direction not assertedBalancedRhea 48864

NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)

Left to rightBalancedRhea 48868

a gentamycin + GTP = a gentamycin 2''-phosphate + GDP + H(+)

Direction not assertedBalance undeterminableRhea 48872

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