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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

851–900 of 18,558 reactions from Rhea

N(4)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP + H(+)
Direction not assertedBalance undeterminableRhea 13581
butanoate + ATP = butanoyl phosphate + ADP
Direction not assertedBalancedRhea 13585
3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)
Direction not assertedBalancedRhea 13589
1,4-diguanidinobutane + H2O = agmatine + urea
Direction not assertedBalancedRhea 13597
cis-4-hydroxy-L-proline + NAD(+) = 4-oxo-L-proline + NADH + H(+)
Right to leftBalancedRhea 13601
2 L-ascorbate + O2 = 2 L-dehydroascorbate + 2 H2O
Direction not assertedBalancedRhea 13605

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)

Left to rightBalance undeterminableRhea 13609

beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + phosphate + H(+)

Direction not assertedBalancedRhea 13613

S-methyl-5'-thioadenosine + H2O = 5-(methylsulfanyl)-D-ribose + adenine

Direction not assertedBalancedRhea 13617

4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucose

Direction not assertedBalance undeterminableRhea 13621

N(6)-dimethylallyladenine + A + H2O = 3-methyl-2-butenal + adenine + AH2

Direction not assertedBalancedRhea 13625

(1S,5R)-carveol + NADP(+) = (R)-carvone + NADPH + H(+)

Direction not assertedBalancedRhea 13629

putrescine + L-glutamate + ATP = gamma-L-glutamylputrescine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 13633

methane + NADH + O2 + H(+) = methanol + NAD(+) + H2O

Direction not assertedBalancedRhea 13637

methane + NADPH + O2 + H(+) = methanol + NADP(+) + H2O

Direction not assertedBalancedRhea 13641

[6)-beta-D-fructofuranosyl-(2->](n) alpha-D-glucopyranoside + sucrose = [6)-beta-D-fructofuranosyl-(2->](n+1) alpha-D-glucopyranoside + D-glucose

Direction not assertedBalance undeterminableRhea 13653

acetyl-[citrate lyase ACP] + H2O = holo-[citrate lyase ACP] + acetate + H(+)

Direction not assertedBalance undeterminableRhea 13657

N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH4(+)

Direction not assertedBalancedRhea 13661

GTP = 3',5'-cyclic GMP + diphosphate

Left to rightBalancedRhea 13665

5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) = 3-hydroxy-2-methylpyridine-5-carboxylate + CO2

Direction not assertedBalancedRhea 13669

[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate

Direction not assertedBalance undeterminableRhea 13673

D-ribulose 5-phosphate = D-xylulose 5-phosphate

Direction not assertedBalancedRhea 13677

a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 13681

lathosterol + NADP(+) = 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H(+)

Direction not assertedBalancedRhea 13685

glycerol + diphosphate = glycerol 1-phosphate + phosphate + H(+)

Direction not assertedBalancedRhea 13689

trimethylsulfonium + (6S)-5,6,7,8-tetrahydrofolate = dimethyl sulfide + (6S)-5-methyl-5,6,7,8-tetrahydrofolate + H(+)

Direction not assertedBalancedRhea 13693

D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 13697

L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA

Direction not assertedBalancedRhea 13701

alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP-N-acetyl-alpha-D-glucosamine = alpha-D-Man-(1->3)-[alpha-D-GlcNAc-(1->2)]-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-D-Man + UDP + H(+)

Direction not assertedBalancedRhea 13705

a ubiquinone + succinate = a ubiquinol + fumarate

Direction not assertedBalance undeterminableRhea 13713

2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH + H(+)

Direction not assertedBalancedRhea 13717

testololactone + H2O = testolate + H(+)

Direction not assertedBalancedRhea 13721

alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H(+)

Direction not assertedBalancedRhea 13725

FAD = riboflavin cyclic-4',5'-phosphate + AMP + H(+)

Direction not assertedBalancedRhea 13729

an n-alkanal + NAD(+) = an alk-2-enal + NADH + H(+)

Direction not assertedBalance undeterminableRhea 13733

an n-alkanal + NADP(+) = an alk-2-enal + NADPH + H(+)

Right to leftBalance undeterminableRhea 13737

3-phenylpyruvate + L-tryptophan = indole-3-pyruvate + L-phenylalanine

Direction not assertedBalancedRhea 13741

ascopyrone M = microthecin

Direction not assertedBalancedRhea 13745

a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP

Direction not assertedBalance undeterminableRhea 13749

2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)

Direction not assertedBalancedRhea 13753

(Z)-2-phenyl-1-thioacetohydroximate + UDP-alpha-D-glucose = (Z)-desulfoglucotropeolin + UDP

Direction not assertedBalancedRhea 13757

L-methionine + S-adenosyl-L-methionine = S-methyl-L-methionine + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 13761

bromochloromethane + H2O = bromide + formaldehyde + chloride + 2 H(+)

Direction not assertedBalancedRhea 13765

glycerol + NAD(+) = dihydroxyacetone + NADH + H(+)

Direction not assertedBalancedRhea 13769

(S)-cheilanthifoline + reduced [NADPH--hemoprotein reductase] + O2 = (S)-stylopine + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 13773

D-ribose 5-phosphate + NH4(+) + ATP = 5-phospho-beta-D-ribosylamine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 13777

an L-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)

Left to rightBalance undeterminableRhea 13781

(3S)-citramalyl-CoA = itaconyl-CoA + H2O

Right to leftBalancedRhea 13785

[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP-alpha-D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)](n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + 2 GDP + 2 H(+)

Direction not assertedBalance undeterminableRhea 13789

2-methyleneglutarate = 2-methylene-3-methylsuccinate

Direction not assertedBalancedRhea 13793

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