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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

8,751–8,800 of 18,558 reactions from Rhea

(2E,6E)-farnesyl diphosphate = alpha-selinene + diphosphate
Direction not assertedBalancedRhea 47052
4alpha-methylzymosterol + 6 Fe(II)-[cytochrome b5] + 3 O2 + 5 H(+) = 4alpha-carboxyzymosterol + 6 Fe(III)-[cytochrome b5] + 4 H2O
Left to rightBalance undeterminableRhea 47056
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O
Direction not assertedBalance undeterminableRhea 47060
4alpha-hydroxymethyl-4beta-methylzymosterol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(III)-[cytochrome b5] + 2 H2O
Direction not assertedBalance undeterminableRhea 47064
4beta-methylzymosterol-4alpha-carbaldehyde + 2 Fe(II)-[cytochrome b5] + O2 + H(+) = 4beta-methylzymosterol-4alpha-carboxylate + 2 Fe(III)-[cytochrome b5] + H2O
Direction not assertedBalance undeterminableRhea 47068
1-eicosanoylglycerol + H2O = eicosanoate + glycerol + H(+)

? Direction not asserted

Balanced

Rhea 47072

17beta-hydroxyandrosta-1,4-dien-3-one + NADPH + H(+) = 17beta-hydroxy-5beta-androst-1-en-3-one + NADP(+)

Left to rightBalancedRhea 47076

17beta-hydroxyestr-4-en-3-one + NADPH + H(+) = 17beta-hydroxy-5beta-estran-3-one + NADP(+)

Left to rightBalancedRhea 47080

4-methylsulfanyl-2-oxobutanoate + L-tyrosine = 3-(4-hydroxyphenyl)pyruvate + L-methionine

Direction not assertedBalancedRhea 47084

(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + NADH + H(+)

Left to rightBalancedRhea 47088

(S)-2,3-dihydrodipicolinate + NADP(+) = dipicolinate + NADPH + H(+)

Direction not assertedBalancedRhea 47092

(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate + 7 diphosphate

Direction not assertedBalancedRhea 47096

choloyl-CoA + taurine = taurocholate + CoA + H(+)

Left to rightBalancedRhea 47100

5,10-methylenetetrahydromethanopterin + glycine + H2O = 5,6,7,8-tetrahydromethanopterin + L-serine

Direction not assertedBalancedRhea 47104

cholate + taurine = taurocholate + H2O

Direction not assertedBalancedRhea 47108

chenodeoxycholate + glycine = glycochenodeoxycholate + H2O

Direction not assertedBalancedRhea 47112

eicosanoate + glycine = N-eicosanoylglycinate + H2O

Direction not assertedBalancedRhea 47116

docosanoate + glycine = N-docosanoylglycine + H2O

Direction not assertedBalancedRhea 47120

hexacosanoate + glycine = N-hexacosanoylglycine + H2O

Direction not assertedBalancedRhea 47124

deoxycholate + ATP + CoA = deoxycholoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 47128

11-cis-retinal + NAD(+) + H2O = 11-cis-retinoate + NADH + 2 H(+)

Left to rightBalancedRhea 47132

lithocholate + ATP + CoA = lithocholoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 47136

(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (6Z,9Z,12Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

Left to rightBalance undeterminableRhea 47140

(9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

Left to rightBalance undeterminableRhea 47144

caffeine + a ubiquinone + H2O = 1,3,7-trimethylurate + a ubiquinol

Direction not assertedBalance undeterminableRhea 47148

2,5-dioxopentanoate + NAD(+) + H2O = 2-oxoglutarate + NADH + 2 H(+)

Direction not assertedBalancedRhea 47152

7alpha,25-dihydroxycholesterol + NAD(+) = 7alpha,25-dihydroxy-4-cholesten-3-one + NADH + H(+)

Left to rightBalancedRhea 47156

4beta-methylzymosterol-4alpha-carboxylate + NAD(+) = 3-dehydro-4-methylzymosterol + CO2 + NADH

Left to rightBalancedRhea 47160

4alpha-carboxyzymosterol + NAD(+) = zymosterone + CO2 + NADH

Left to rightBalancedRhea 47164

4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADH

Left to rightBalancedRhea 47168

4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol + NAD(+) = 5alpha-cholest-8-en-3-one + CO2 + NADH

Left to rightBalancedRhea 47172

(2R)-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O

Direction not assertedBalancedRhea 47176

(25R)-cholest-5-en-3beta,7alpha,26-triol + NAD(+) = (25R)-7alpha,26-dihydroxycholest-4-en-3-one + NADH + H(+)

Left to rightBalancedRhea 47180

5alpha-cholesta-7,24-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 7-dehydrodesmosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O

Left to rightBalance undeterminableRhea 47184

Co(I)-[methylated-thiol-specific corrinoid protein] + methanethiol = methyl-Co(III)-[methylated-thiol-specific corrinoid protein] + hydrogen sulfide

Direction not assertedBalance undeterminableRhea 47188

methyl-Co(III)-[methylated-thiol-specific corrinoid protein] + coenzyme M = Co(I)-[methylated-thiol-specific corrinoid protein] + methyl-coenzyme M + H(+)

Direction not assertedBalance undeterminableRhea 47192

a short-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]

Left to rightBalance undeterminableRhea 47196

(24S)-7alpha-dihydroxycholesterol + NAD(+) = (24S)-7alpha,24-dihydroxycholest-4-en-3-one + NADH + H(+)

Left to rightBalancedRhea 47200

estrone + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxyestrone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 47204

estrone + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxyestrone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 47208

17beta-estradiol + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxy-17beta-estradiol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 47212

17beta-estradiol + reduced [NADPH--hemoprotein reductase] + O2 = 6beta-hydroxyestradiol-17beta + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 47216

3beta-hydroxyandrost-5-en-17-one + reduced [NADPH--hemoprotein reductase] + O2 = 3beta,16alpha-dihydroxy-androst-5-en-17-one + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 47220

dehydroepiandrosterone 3-sulfate + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxydehydroepiandrosterone 3-sulfate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 47224

docosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]

Left to rightBalance undeterminableRhea 47228

tetracosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]

Left to rightBalance undeterminableRhea 47232

eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]

Left to rightBalance undeterminableRhea 47236

octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]

Left to rightBalance undeterminableRhea 47240

an NDP-alpha-D-glucose + (2R)-3-phosphoglycerate = (2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + a ribonucleoside 5'-diphosphate + H(+)

Direction not assertedBalance undeterminableRhea 47244

L-gulono-1,4-lactone + 2 Fe(III)-[cytochrome c] = L-ascorbate + 2 Fe(II)-[cytochrome c] + 3 H(+)

Direction not assertedBalance undeterminableRhea 47248

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