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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

8,651–8,700 of 18,558 reactions from Rhea

7alpha-hydroxycholest-4-en-3-one + NADPH + H(+) = 7alpha-hydroxy-5beta-cholestan-3-one + NADP(+)
Left to rightBalancedRhea 46640
cortisol + NADPH + H(+) = 5beta-dihydrocortisol + NADP(+)
Left to rightBalancedRhea 46644
17-hydroxy-3-oxochol-4-en-22-oyl-CoA = androst-4-ene-3,17-dione + propanoyl-CoA
Direction not assertedBalancedRhea 46648
epitestosterone + NADPH + H(+) = 5beta-dihydroepitestosterone + NADP(+)
Left to rightBalancedRhea 46652
androst-4-ene-3,17-dione + NADPH + H(+) = 5beta-androstane-3,17-dione + NADP(+)
Left to rightBalancedRhea 46656
progesterone + NADPH + H(+) = 5beta-pregnan-3,20-dione + NADP(+)
Left to rightBalancedRhea 46660
corticosterone + NADPH + H(+) = 5beta-dihydrocorticosterone + NADP(+)

→ Left to right

Balanced

Rhea 46664

21-hydroxyprogesterone + NADPH + H(+) = 5beta-dihydrodeoxycorticosterone + NADP(+)

Left to rightBalancedRhea 46668

aldosterone + NADPH + H(+) = 5beta-dihydroaldosterone + NADP(+)

Direction not assertedBalancedRhea 46672

(4R)-hydroxy-(6R)-2,2,6-trimethylcyclohexanone + NAD(+) = (6R)-2,2,6-trimethyl-1,4-cyclohexanedione + NADH + H(+)

Direction not assertedBalancedRhea 46676

2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)

Left to rightBalance undeterminableRhea 46680

3-oxochol-4-en-24-oyl-CoA + A = (22E)-3-oxochola-4,22-dien-24-oyl-CoA + AH2

Direction not assertedBalancedRhea 46684

(25S)-3-oxocholest-4-en-26-oyl-CoA + A = 3-oxo-cholest-4,24-dien-26-oyl-CoA + AH2

Direction not assertedBalancedRhea 46688

4-hydroxybenzoate + ATP + H(+) = 4-hydroxybenzoyl-5'-AMP + diphosphate

Direction not assertedBalancedRhea 46692

a pseudouridine in rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 46696

(R)-lipoate + GTP + H(+) = (R)-lipoyl-GMP + diphosphate

Left to rightBalancedRhea 46700

salicylate + ATP + H(+) = 2-hydroxybenzoyl-5'-AMP + diphosphate

Direction not assertedBalancedRhea 46704

2-hydroxybenzoyl-5'-AMP + holo-[ACP] = salicyl-[ACP] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 46708

pseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 46712

pseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-methionine = N(1)-methylpseudouridine(914) in M. jannaschii 16S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 46716

(3R)-hydroxyhexanoyl-CoA = (2E)-hexenoyl-CoA + H2O

Direction not assertedBalancedRhea 46720

(2S)-2-methyltetradecanoyl-CoA = (2R)-2-methyltetradecanoyl-CoA

Direction not assertedBalancedRhea 46724

(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2

Left to rightBalancedRhea 46728

(2R,6)-dimethylheptanoyl-CoA = (2S,6)-dimethylheptanoyl-CoA

Left to rightBalancedRhea 46732

a monoacyl-sn-glycero-3-phosphate + H2O = a monoacylglycerol + phosphate

Left to rightBalance undeterminableRhea 46736

7-dehydrodesmosterol + NADPH + H(+) = desmosterol + NADP(+)

Left to rightBalancedRhea 46740

hydrogencarbonate + ATP = carboxyphosphate + ADP

Direction not assertedBalancedRhea 46744

carboxyphosphate + NH4(+) = carbamate + phosphate + 2 H(+)

Direction not assertedBalancedRhea 46748

7alpha-hydroxycholest-4-en-3-one + reduced [NADPH--hemoprotein reductase] + O2 = 7alpha,12alpha-dihydroxycholest-4-en-3-one + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 46752

a 1-acyl-2-hexadecanoyl-glycerolipid + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 1-acyl-2-[(7Z)-hexadecenoyl]-glycerolipid + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 46756

2,4-dinitrotoluene + NADH + O2 = 4-methyl-5-nitrocatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 46760

a 1-acyl-2-hexadecanoyl-glycerolipid + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 1-acyl-2-[(3E)-hexadec-3-enoyl]-glycerolipid + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 46764

a 1-acyl-2-hexadecanoyl-glycerolipid + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 1-acyl-2-[(9Z)-hexadecenoyl]-glycerolipid + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 46768

a 1-octadecanoyl 2-acyl-glycerolipid + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 46772

a 1-[(9Z)-octadecenoyl]-2-acyl-glycerolipid + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 46776

a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 46780

a 1-[(9Z,12Z)-octadecdienoyl]-2-acyl-glycerolipid + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 1-[(9Z,12Z,15Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 46784

a 1-[(6Z,9Z,12Z)-octadectrienoyl]-2-acyl-glycerolipid + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 1-[(6Z,9Z,12Z,15Z)-octadectetraenoyl]-2-acyl-glycerolipid + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 46788

an (11Z,14Z)-icosadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an (8Z,11Z,14Z)-icosatrienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46792

an (11Z,14Z,17Z)-icosatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an (8Z,11Z,14Z,17Z)-eicosatetraenoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46796

2 reduced [2Fe-2S]-[ferredoxin] + Na(+)(in) + NAD(+) + H(+) = 2 oxidized [2Fe-2S]-[ferredoxin] + Na(+)(out) + NADH

Direction not assertedBalance undeterminableTransportRhea 46800

a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine = a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 46804

[trehalose-6-phosphate synthase]-L-cysteine + S-adenosyl-L-methionine = [trehalose-6-phosphate synthase]-S-methyl-L-cysteine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 46808

4,4-dimethyl-8,14-cholestadien-3beta-ol + NADPH + H(+) = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)

Direction not assertedBalancedRhea 46812

4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 46816

4alpha-hydroxymethyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46820

4alpha-hydroxyformyl-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + O2 + H(+) = 4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 46824

4alpha-carboxy-4beta-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-8-en-3-one + CO2 + NADPH

Left to rightBalancedRhea 46828

4alpha-methyl-5alpha-cholest-8-en-3-one + NADPH + H(+) = 4alpha-methyl-5alpha-cholest-8-en-3beta-ol + NADP(+)

Left to rightBalancedRhea 46832

4alpha-methyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 4alpha-hydroxymethyl-5alpha-cholest-8-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 46836

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