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ReactionsRhea and Human-GEM, by subsystem
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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

8,601–8,650 of 18,558 reactions from Rhea

(25R)-3beta,4beta-dihydroxycholest-5-en-26-al + 2 reduced [adrenodoxin] + O2 + H(+) = (25R)-3beta,4beta-dihydroxycholest-5-en-26-oate + 2 oxidized [adrenodoxin] + H2O
Left to rightBalance undeterminableRhea 46436
a (9Z,12Z)-octadecadienoyl-containing glycerolipid + AH2 + O2 = a (8E,10E,12Z)-octadecatrienoyl-containing glycerolipid + A + 2 H2O
Direction not assertedBalance undeterminableRhea 46440
(11Z)-hexadecenoyl-CoA + AH2 + O2 = (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O
Direction not assertedBalancedRhea 46444
2 L-tyrosyl-tRNA(Tyr) = cyclo(L-tyrosyl-L-tyrosyl) + 2 tRNA(Tyr)
Direction not assertedBalancedRhea 46448
2 L-leucyl-tRNA(Leu) = cyclo(L-leucyl-L-leucyl) + 2 tRNA(Leu) + 2 H(+)
Direction not assertedBalancedRhea 46452
5alpha-cholest-8,14-dien-3beta-ol + NADPH + H(+) = 5alpha-cholest-8-en-3beta-ol + NADP(+)
Direction not assertedBalancedRhea

46456

(22R)-hydroxycholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (22R,7alpha)-dihydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 46460

(24S)-25-epoxycholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S,25)-epoxy-7alpha-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 46464

an N-(acyl)-sphingosylphosphocholine(in) + ATP + H2O = an N-(acyl)-sphingosylphosphocholine(out) + ADP + phosphate + H(+)

Left to rightBalance undeterminableTransportRhea 46468

4alpha-methylzymosterol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 4alpha-hydroxymethylzymosterol + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 46472

4alpha-hydroxymethylzymosterol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 4alpha-formylzymosterol + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46476

4alpha-formylzymosterol + 2 Fe(II)-[cytochrome b5] + O2 + H(+) = 4alpha-carboxyzymosterol + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 46480

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)

Direction not assertedBalancedRhea 46484

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(in) = 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine(out)

Left to rightBalancedTransportRhea 46488

1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(in) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine(out)

Left to rightBalancedTransportRhea 46492

N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(in) = N-(hexadecanoyl)-sphing-4-enine-1-phosphocholine(out)

Left to rightBalancedTransportRhea 46496

UMP + 2-oxoglutarate + O2 = uridine-5'-aldehyde + succinate + CO2 + phosphate

Direction not assertedBalancedRhea 46500

dodecanoyl-AMP + holo-[ACP] = dodecanoyl-[ACP] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 46504

nitrobenzene + NADH + O2 = catechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 46508

an N-(1,2-saturated acyl)sphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-[(2'R)-hydroxyacyl]sphinganine + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 46512

dodecanoyl-[ACP] + FAD + H(+) = (2Z)-dodecenoyl-[ACP] + FADH2

Direction not assertedBalance undeterminableRhea 46516

an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 46520

(11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46524

(11Z,14Z,17Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46528

a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (9Z,11E,13Z)-octadeca-9,11,13-trienoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46532

(6Z,9Z,12Z)-octadecatrienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46536

(6Z,9Z,12Z,15Z)-octadecatetraenoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (9Z,12Z,15Z)-octadeca-9,12,15-trien-6-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46540

an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O

Left to rightBalance undeterminableRhea 46544

a (4E,8E)-4-sphinga-4,8-dienine ceramide + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acyl-(4E,8E,10E)-sphingatrienine + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46548

a (9Z,12Z)-octadecadienoyl-containing glycerolipid + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a (9Z)-octadec-9-en-12-ynoyl-containing glycerolipid + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46552

lathosterol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 7-dehydrocholesterol + 2 Fe(III)-[cytochrome b5] + 2 H2O

Left to rightBalance undeterminableRhea 46556

episterol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 5-dehydroepisterol + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 46560

apo-[ACP] + acetyl-CoA = acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalance undeterminableRhea 46564

5-hexenoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 5-hexynoyl-[ACP] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 46568

hexanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 5-hexenoyl-[ACP] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 46572

sitosterol + NADPH + O2 + H(+) = stigmasterol + NADP(+) + 2 H2O

Direction not assertedBalancedRhea 46576

vitamin D2 + reduced [NADPH--hemoprotein reductase] + O2 = 25-hydroxyvitamin D2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 46580

1alpha-hydroxyvitamin D2 + reduced [NADPH--hemoprotein reductase] + O2 = 1alpha,25-dihydroxyvitamin D2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 46584

calciol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = calcidiol + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 46588

alfacalcidol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = calcitriol + 2 oxidized [adrenodoxin] + H2O

Direction not assertedBalance undeterminableRhea 46592

[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)

Direction not assertedBalance undeterminableRhea 46600

[HPr protein]-O-phospho-L-serine + phosphate + H(+) = [HPr protein]-L-serine + diphosphate

Direction not assertedBalance undeterminableRhea 46604

L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)

Left to rightBalance undeterminableRhea 46608

(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + cholesterol = (5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterol + CoA

Left to rightBalancedRhea 46612

calcidiol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = (23S)-23,25-dihydroxycalciol + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 46616

(9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA

Left to rightBalancedRhea 46620

a D-5-monosubstituted hydantoin = a L-5-monosubstituted hydantoin

Direction not assertedBalance undeterminableRhea 46624

3beta-hydroxyandrost-5-en-17-one + NADPH + H(+) = androst-5-en-3beta,17beta-diol + NADP(+)

Left to rightBalancedRhea 46628

7alpha,12alpha-dihydroxycholest-4-en-3-one + NADPH + H(+) = 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP(+)

Left to rightBalancedRhea 46632

5beta-dihydrotestosterone + NADP(+) = testosterone + NADPH + H(+)

Direction not assertedBalancedRhea 46636

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