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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
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Reactions
Reach

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Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

8,301–8,350 of 18,558 reactions from Rhea

a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(2E)-enoyl-CoA + NADP(+)
Direction not assertedBalance undeterminableRhea 45232
(25R)-3beta-hydroxy-5-cholesten-26-al + 2 reduced [adrenodoxin] + O2 + H(+) = (25R)-3beta-hydroxy-5-cholestenoate + 2 oxidized [adrenodoxin] + H2O
Left to rightBalance undeterminableRhea 45236
a (3E,5Z)-dienoyl-CoA = a (2E,4E)-(5,6-saturated)-dienoyl-CoA
Left to rightBalance undeterminableRhea 45240
(3E,5Z)-octadienoyl-CoA = (2E,4E)-octadienoyl-CoA
Left to rightBalancedRhea 45244
butanoate(out) = butanoate(in)
Direction not assertedBalancedTransportRhea 45248
tetradecanoate(out) = tetradecanoate(in)
Direction not assertedBalancedTransportRhea 45252
hexadecanoate(out) = hexadecanoate(in)

Direction not assertedBalancedTransportRhea 45256

tetracosanoate(out) = tetracosanoate(in)

Direction not assertedBalancedTransportRhea 45260

(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)-octadecadienoate(in)

Direction not assertedBalancedTransportRhea 45264

4'-hydroxyechinenone + AH2 + O2 = 4',4'-dihydroxyechinenone + A + H2O

Direction not assertedBalancedRhea 45268

12-phosphooxy-(9Z)-octadecenoate + H2O = 12-hydroxy-(9Z)-octadecenoate + phosphate

Left to rightBalancedRhea 45272

12-phosphooxy-(9E)-octadecenoate + H2O = 12-hydroxy-(9E)-octadecenoate + phosphate

Left to rightBalancedRhea 45276

12-(phosphooxy)octadecanoate + H2O = 12-hydroxyoctadecanoate + phosphate

Left to rightBalancedRhea 45280

eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)

Left to rightBalancedRhea 45284

2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 2 O2 = 2-glyceryl-prostaglandin G2

Left to rightBalancedRhea 45288

2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O

Left to rightBalancedRhea 45292

a sphingosylphosphocholine + H2O = a sphingoid base + phosphocholine + H(+)

Left to rightBalance undeterminableRhea 45296

an N-(acyl)-sphingosylphosphocholine + H2O = an N-acyl-sphingoid base + phosphocholine + H(+)

Left to rightBalance undeterminableRhea 45300

1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphocholine + H(+)

Left to rightBalancedRhea 45304

prostaglandin D2-ethanolamide + NADPH + H(+) = 11beta-prostaglandin F2-ethanolamide + NADP(+)

Left to rightBalancedRhea 45308

prostaglandin F2alpha + NADP(+) = prostaglandin H2 + NADPH + H(+)

Right to leftBalancedRhea 45312

prostaglandin D2 + NADPH + H(+) = 11beta-prostaglandin F2 + NADP(+)

Left to rightBalancedRhea 45316

N-(15Z-tetracosenoyl)sphing-4-enine-1-phosphocholine + H2O = N-(15Z-tetracosenoyl)-sphing-4-enine + phosphocholine + H(+)

Left to rightBalancedRhea 45320

N-(tetracosanoyl)-sphing-4-enine-1-phosphocholine + H2O = N-tetracosanoyl-sphing-4-enine + phosphocholine + H(+)

Left to rightBalancedRhea 45324

7,8-dihydroneopterin = 7,8-dihydromonapterin

Direction not assertedBalancedRhea 45328

7,8-dihydroneopterin + O2 = 7,8-dihydroxanthopterin + glycolaldehyde + formate + H(+)

Direction not assertedBalancedRhea 45332

[Wnt protein]-L-serine + (9Z)-hexadecenoyl-CoA = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA

Direction not assertedBalance undeterminableRhea 45336

[Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + H2O = [Wnt protein]-L-serine + (9Z)-hexadecenoate + H(+)

Direction not assertedBalance undeterminableRhea 45340

a globoside NOR1 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a globoside NORint (d18:1(4E)) + UDP + H(+)

Direction not assertedBalance undeterminableRhea 45344

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphing-4-enine + H2O = sphing-4-enine + (5Z,8Z,11Z,14Z)-eicosatetraenoate

Left to rightBalancedRhea 45348

9,10-epoxyoctadecanoate + H2O = 9,10-dihydroxyoctadecanoate

Left to rightBalancedRhea 45352

N-(11Z-eicosenoyl)-sphing-4-enine + H2O = (11Z)-eicosenoate + sphing-4-enine

Left to rightBalancedRhea 45356

N-(11Z-eicosenoyl)-sphinganine + H2O = (11Z)-eicosenoate + sphinganine

Left to rightBalancedRhea 45360

N-(11Z-eicosenoyl)-(4R)-hydroxysphinganine + H2O = (11Z)-eicosenoate + (4R)-hydroxysphinganine

Left to rightBalancedRhea 45364

N-(9Z-octadecenoyl)-(4R)-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + (9Z)-octadecenoate

Left to rightBalancedRhea 45368

N-(9Z-octadecenoyl)-sphinganine + H2O = sphinganine + (9Z)-octadecenoate

Left to rightBalancedRhea 45372

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sphinganine + H2O = sphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate

Left to rightBalancedRhea 45376

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-(4R)-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + (5Z,8Z,11Z,14Z)-eicosatetraenoate

Left to rightBalancedRhea 45380

N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)

Left to rightBalancedRhea 45384

N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-octadecanoyl-sn-glycero-3-phospho-ethanolamine + (9Z)-octadecenoate + H(+)

Left to rightBalancedRhea 45388

N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-eicosanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)

Left to rightBalancedRhea 45392

N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)

Left to rightBalancedRhea 45396

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)

Left to rightBalancedRhea 45400

1-O-(9Z-octadecenyl)-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-(9Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 45404

(2E)-dodecenoyl-CoA + NADH + H(+) = dodecanoyl-CoA + NAD(+)

Direction not assertedBalancedRhea 45408

prostaglandin D2-1-glycerol ester + H2O = prostaglandin D2 + glycerol + H(+)

Left to rightBalancedRhea 45412

2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 + H2O = 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+)

Left to rightBalancedRhea 45416

N,1-diacyl-sn-glycero-3-phosphoethanolamine + H2O = N-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 45420

N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)

Left to rightBalancedRhea 45424

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + sn-glycerol 3-phosphate + H(+)

Left to rightBalancedRhea 45428

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