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ReactionsRhea and Human-GEM, by subsystem
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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

7,701–7,750 of 18,558 reactions from Rhea

(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA
Left to rightBalancedRhea 42816
tetracenomycin A2 + 2 NADPH + 2 O2 + 2 H(+) = tetracenomycin C + 2 NADP(+) + H2O
Direction not assertedBalancedRhea 42820
tetracenomycin A2 + 2 NADH + 2 O2 + 2 H(+) = tetracenomycin C + 2 NAD(+) + H2O
Direction not assertedBalancedRhea 42824
2-hydroxy-5-methyl-1-naphthoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O
Direction not assertedBalance undeterminableRhea 42828
(2E)-octenal + pyruvate + H(+) = (S)-3-acetyloctanal + CO2
Direction not assertedBalancedRhea 42832
5 malonyl-CoA + acetyl-CoA + 3 NADPH + 7 H(+) = 5-methyl-1-naphthoate + 5 CO2 + 3 NADP(+) + 6 CoA + 4 H2O
Direction not assertedBalancedRhea 42836

5 malonyl-CoA + acetyl-CoA + 2 NADPH + 6 H(+) = 2-hydroxy-5-methyl-1-naphthoate + 5 CO2 + 2 NADP(+) + 6 CoA + 3 H2O

Direction not assertedBalancedRhea 42840

6 (S)-methylmalonyl-CoA + malonyl-CoA + 5 NADPH + 12 H(+) = narbonolide + 7 CO2 + 5 NADP(+) + 7 CoA + 2 H2O

Direction not assertedBalancedRhea 42844

8-demethyltetracenomycin C + dTDP-beta-L-rhamnose = 8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + dTDP + H(+)

Direction not assertedBalancedRhea 42848

holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + S-adenosyl-L-methionine + 2 NADPH + 3 H(+) = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + S-adenosyl-L-homocysteine + 2 CO2 + 2 NADP(+) + 2 CoA + H2O

Direction not assertedBalance undeterminableRhea 42852

1,2-dioctanoyl-sn-glycero-3-diphosphate + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + phosphate + H(+)

Left to rightBalancedRhea 42856

1,2-dioctanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctanoyl-sn-glycerol + phosphate

Left to rightBalancedRhea 42860

norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine = norspermine + S-methyl-5'-thioadenosine + H(+)

Direction not assertedBalancedRhea 42864

norspermine + S-adenosyl 3-(methylsulfanyl)propylamine = caldopentamine + S-methyl-5'-thioadenosine + 2 H(+)

Direction not assertedBalancedRhea 42868

N(4)-aminopropylspermidine + S-adenosyl 3-(methylsulfanyl)propylamine = N(4)-bis(aminopropyl)spermidine + S-methyl-5'-thioadenosine + H(+)

Direction not assertedBalancedRhea 42872

S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = N(4)-aminopropylspermidine + S-methyl-5'-thioadenosine + H(+)

Direction not assertedBalancedRhea 42876

spermine + S-adenosyl 3-(methylsulfanyl)propylamine = N(4)-aminopropylspermine + S-methyl-5'-thioadenosine + H(+)

Direction not assertedBalancedRhea 42880

(R)-mevalonate + ATP = (R)-3-phosphomevalonate + ADP + H(+)

Direction not assertedBalancedRhea 42884

(R)-3-phosphomevalonate + ATP = (R)-3,5-bisphosphomevalonate + ADP + H(+)

Direction not assertedBalancedRhea 42888

5'-deoxyadenosine + H2O + H(+) = 5'-deoxyinosine + NH4(+)

Direction not assertedBalancedRhea 42892

L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 42896

guanosine(745) in 23S rRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(745) in 23S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 42900

guanosine(748) in 23S rRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(748) in 23S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 42904

uridine(1939) in 23S rRNA + S-adenosyl-L-methionine = 5-methyluridine(1939) in 23S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 42908

cytidine(1962) in 23S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(1962) in 23S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 42912

adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 42916

uridine(1498) in 16S rRNA + S-adenosyl-L-methionine = N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 42920

cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 42924

cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 42928

cytidine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32) in tRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 42932

uridine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methyluridine(32) in tRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 42936

cytidine(34) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(34) in tRNA precursor + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 42940

cytidine(40) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(40) in tRNA precursor + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 42944

cytidine(48) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 42948

cytidine(49) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 42952

cytidine(38) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(38) in tRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 42956

2 reduced [nitric oxide reductase rubredoxin domain] + NAD(+) + H(+) = 2 oxidized [nitric oxide reductase rubredoxin domain] + NADH

Direction not assertedBalance undeterminableRhea 42960

uridine(54/55) in tRNA = pseudouridine(54/55) in tRNA

Direction not assertedBalancedRhea 42964

cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 42968

a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a cardiolipin + ethanolamine

Direction not assertedBalance undeterminableRhea 42972

L-tryptophan = indole + 2-aminoprop-2-enoate

Direction not assertedBalancedRhea 42976

L-tyrosine = phenol + 2-aminoprop-2-enoate

Direction not assertedBalancedRhea 42980

(+)-copalyl diphosphate = (-)-pimara-8(14),15-diene + diphosphate

Direction not assertedBalancedRhea 42984

(2E,6E,10E)-geranylgeranyl diphosphate = cembrene C + diphosphate

Direction not assertedBalancedRhea 42988

(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (R)-nephthenol + diphosphate

Direction not assertedBalancedRhea 42992

(2E,6E,10E)-geranylgeranyl diphosphate = (R)-cembrene A + diphosphate

Direction not assertedBalancedRhea 42996

(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol + diphosphate

Direction not assertedBalancedRhea 43000

O-carbamoyl-L-serine + H(+) = 2-aminoprop-2-enoate + NH4(+) + CO2

Direction not assertedBalancedRhea 43004

D-serine = 2-aminoprop-2-enoate + H2O

Direction not assertedBalancedRhea 43008

L-homocysteine = 2-aminobut-2-enoate + hydrogen sulfide + H(+)

Direction not assertedBalancedRhea 43012

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