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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
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Reactions
Reach

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Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

7,601–7,650 of 18,558 reactions from Rhea

lactose(out) + N(pros)-phospho-L-histidyl-[protein] = lactose 6-phosphate(in) + L-histidyl-[protein]
Direction not assertedBalance undeterminableRhea 42400
lactose 6-phosphate + H2O = D-galactose 6-phosphate + beta-D-glucose
Direction not assertedBalancedRhea 42404
(2R)-2-phosphoglycerate + ATP = (2R)-2,3-bisphosphoglycerate + ADP + H(+)
Direction not assertedBalancedRhea 42408
(2R)-2,3-bisphosphoglycerate + ATP + H(+) = cyclic (2R)-2,3-bisphosphoglycerate + ADP + phosphate
Direction not assertedBalancedRhea 42412
a ubiquinone + L-proline = (S)-1-pyrroline-5-carboxylate + a ubiquinol + H(+)
Direction not assertedBalance undeterminableRhea 42416
L-lysine + 2-oxoglutarate + O2 = (4R)-4-hydroxy-L-lysine + succinate + CO2
Direction not assertedBalancedRhea 42420

2-methylmaleate + H2O = (2R,3S)-3-methylmalate

Direction not assertedBalancedRhea 42424

clavaminate = (3R,5R)-clavulanate-9-aldehyde

Direction not assertedUnbalancedRhea 42428

3-hydroxy-cis,cis-muconate = maleylacetate

Direction not assertedBalancedRhea 42432

N(pros)-phospho-L-histidyl-[protein] + L-ascorbate(out) = L-ascorbate 6-phosphate(in) + L-histidyl-[protein]

Direction not assertedBalance undeterminableRhea 42436

L-aspartate + NAD(+) = iminosuccinate + NADH + H(+)

Direction not assertedBalancedRhea 42440

L-aspartate + NADP(+) = iminosuccinate + NADPH + H(+)

Direction not assertedBalancedRhea 42444

(R)-2-hydroxyglutaryl-CoA = (2E)-glutaconyl-CoA + H2O

Direction not assertedBalancedRhea 42448

4-(2-aminophenyl)-2,4-dioxobutanoate = kynurenate + H2O

Direction not assertedBalancedRhea 42452

4alpha-methylzymosterol = zymosterol

Direction not assertedUnbalancedRhea 42456

dibenzofuran + NADH + O2 + H(+) = biphenyl-2,2',3-triol + NAD(+)

Direction not assertedBalancedRhea 42460

biphenyl-2,2',3-triol + O2 = 2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + 2 H(+)

Direction not assertedBalancedRhea 42464

2-hydroxy-6-(2-hydroxyphenyl)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + salicylate

Direction not assertedBalancedRhea 42468

dibenzo-p-dioxin + NADH + O2 = 2,2',3-trihydroxydiphenyl ether + NAD(+) + H(+)

Direction not assertedBalancedRhea 42472

2,2',3-trihydroxydiphenyl ether + O2 + H(+) = 2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate

Direction not assertedBalancedRhea 42476

2-hydroxy-6-(2-hydroxyphenoxy)-6-oxo-cis,cis-hexa-2,4-dienoate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + catechol + H(+)

Direction not assertedBalancedRhea 42480

D-sorbitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-sorbitol 6-phosphate(in) + L-histidyl-[protein]

Direction not assertedBalance undeterminableRhea 42484

baccatin III + (3R)-3-amino-3-phenylpropanoyl-CoA = 3'-N-debenzoyl-2'-deoxytaxol + CoA

Direction not assertedBalancedRhea 42488

3'-N-debenzoyl-2'-deoxytaxol + reduced [NADPH--hemoprotein reductase] + O2 = 3'-N-debenzoyltaxol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 42492

(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NADP(+) = 6-lactoyl-5,6,7,8-tetrahydropterin + NADPH + H(+)

Direction not assertedBalancedRhea 42500

N(6)-acetyl-L-lysine + 2-oxoglutarate = 6-acetamido-2-oxohexanoate + L-glutamate

Direction not assertedBalancedRhea 42504

6-acetamido-2-oxohexanoate + NAD(+) + H2O = 5-acetamidopentanoate + CO2 + NADH + H(+)

Direction not assertedBalancedRhea 42508

5-acetamidopentanoate + H2O = 5-aminopentanoate + acetate

Direction not assertedBalancedRhea 42512

L-gulono-1,4-lactone + H2O = L-gulonate + H(+)

Direction not assertedBalancedRhea 42516

uridine(2605) in 23S rRNA = pseudouridine(2605) in 23S rRNA

Direction not assertedBalancedRhea 42520

uridine(1911/1915/1917) in 23S rRNA = pseudouridine(1911/1915/1917) in 23S rRNA

Direction not assertedBalancedRhea 42524

uridine(955/2504/2580) in 23S rRNA = pseudouridine(955/2504/2580) in 23S rRNA

Direction not assertedBalancedRhea 42528

uridine(55) in tRNA = pseudouridine(55) in tRNA

Left to rightBalancedRhea 42532

uridine(65) in tRNA = pseudouridine(65) in tRNA

Direction not assertedBalancedRhea 42536

uridine(13) in tRNA = pseudouridine(13) in tRNA

Direction not assertedBalancedRhea 42540

uridine(32) in tRNA = pseudouridine(32) in tRNA

Direction not assertedBalancedRhea 42544

uridine(746) in 23S rRNA = pseudouridine(746) in 23S rRNA

Direction not assertedBalancedRhea 42548

uridine(31) in tRNA = pseudouridine(31) in tRNA

Direction not assertedBalancedRhea 42552

uridine(2819) in 21S rRNA = pseudouridine(2819) in 21S rRNA

Direction not assertedBalancedRhea 42556

uridine(27/28) in mitochondrial tRNA = pseudouridine(27/28) in mitochondrial tRNA

Direction not assertedBalancedRhea 42560

uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA

Direction not assertedBalancedRhea 42564

2,3-dihydroxy-p-cumate + O2 = 3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+)

Direction not assertedBalancedRhea 42568

3-carboxy-2-hydroxy-7-methyl-6-oxo-(2Z,4Z)-octadienoate + H(+) = 2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + CO2

Direction not assertedBalancedRhea 42572

2-hydroxy-7-methyl-6-oxo-(2E,4E)-octadienoate + H2O = 2-oxopent-4-enoate + 2-methylpropanoate + H(+)

Direction not assertedBalancedRhea 42576

tRNA(Sec) + L-serine + ATP = L-seryl-tRNA(Sec) + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 42580

1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate

Left to rightBalancedRhea 42584

1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 42588

1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 42592

(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2

Left to rightBalancedRhea 42596

prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O

Left to rightBalancedRhea 42600

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