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ReactionsRhea and Human-GEM, by subsystem
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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

7,351–7,400 of 18,558 reactions from Rhea

toluene + NADH + O2 + H(+) = 4-methylphenol + NAD(+) + H2O
Direction not assertedBalancedRhea 41380
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)
Left to rightBalancedRhea 41384
1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = nonanedioate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
Left to rightBalancedRhea 41388
2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + choline + H(+)
Direction not assertedBalancedRhea 41392
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine = 1-O-(1Z-alkenyl)-2-acetyl-sn-glycero-3-phosphoethanolamine + 1-O-hexadecyl-sn-glycero-3-phosphocholine
Left to rightBalance undeterminableRhea 41396
1-hexanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexanoyl-sn-glycero-3-phosphate + choline + H(+)
Left to right

Balanced

Rhea 41400

(R)-2-methylpyrrolidine + NADP(+) = 2-methyl-1-pyrroline + NADPH + H(+)

Direction not assertedBalancedRhea 41404

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)

Left to rightBalancedRhea 41408

1,2-didecanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-didecanoyl-sn-glycero-3-phosphate + choline + H(+)

Left to rightBalancedRhea 41412

1,2-dioctanoyl-sn-glycero-3-phosphocholine + H2O = 1,2-dioctanoyl-sn-glycero-3-phosphate + choline + H(+)

Left to rightBalancedRhea 41416

2 3-amino-4-hydroxybenzoate + N-acetyl-L-cysteine + 2 O2 + H(+) = grixazone B + CO2 + 4 H2O

Direction not assertedBalancedRhea 41420

2 3-amino-4-hydroxybenzaldehyde + N-acetyl-L-cysteine + 2 O2 = grixazone A + formate + 3 H2O + H(+)

Direction not assertedBalancedRhea 41424

L-tyrosine + S-adenosyl-L-methionine = 3-methyl-L-tyrosine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 41428

3-methyl-L-tyrosine + H2O2 = 5-hydroxy-3-methyl-L-tyrosine + H2O

Direction not assertedBalancedRhea 41432

cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA

Left to rightBalancedRhea 41436

(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (1R)-(2-amino-1-hydroxyethyl)phosphonate + succinate + CO2

Direction not assertedBalancedRhea 41440

(1R)-(2-amino-1-hydroxyethyl)phosphonate + O2 = glycine + phosphate + 2 H(+)

Direction not assertedBalancedRhea 41444

L-isoleucine + 2-oxoglutarate + O2 = (4S)-4-hydroxy-L-isoleucine + succinate + CO2

Direction not assertedBalancedRhea 41448

5-methyl-1-naphthoate + NADPH + O2 + H(+) = 3-hydroxy-5-methyl-1-naphthoate + NADP(+) + H2O

Direction not assertedBalancedRhea 41452

1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + an N-acylsphing-4-enine = an N-acylsphing-4-enine 1-phosphoethanolamine + 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol

Direction not assertedBalance undeterminableRhea 41456

1,2-diacyl-glycero-3-phosphocholine + an N-acylsphing-4-enine = a sphingomyelin + a 1,2-diacylglycerol

Direction not assertedBalance undeterminableRhea 41460

ent-sandaracopimara-8(14),15-diene + reduced [NADPH--hemoprotein reductase] + O2 = ent-sandaracopimaradien-3beta-ol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 41464

ent-sandaracopimaradien-3beta-ol + reduced [NADPH--hemoprotein reductase] + O2 = oryzalexin E + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 41468

ent-sandaracopimaradien-3beta-ol + reduced [NADPH--hemoprotein reductase] + O2 = oryzalexin D + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 41472

zymosterol + an acyl-CoA = zymosterol ester + CoA

Direction not assertedBalance undeterminableRhea 41476

episterol + an acyl-CoA = an episterol ester + CoA

Direction not assertedBalance undeterminableRhea 41480

1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine

Left to rightBalancedRhea 41484

1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine

Left to rightBalancedRhea 41488

1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine

Left to rightBalancedRhea 41492

1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine

Left to rightBalancedRhea 41496

1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine

Left to rightBalancedRhea 41500

L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O

Direction not assertedBalancedRhea 41508

L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O

Direction not assertedBalancedRhea 41512

phylloquinone + reduced [NADPH--hemoprotein reductase] + O2 = omega-hydroxyphylloquinone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 41516

menaquinone-4 + reduced [NADPH--hemoprotein reductase] + O2 = omega-hydroxymenaquinone-4 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 41520

5 malonyl-CoA + 5 H(+) = naphthalene-1,3,6,8-tetrol + 5 CO2 + 5 CoA + H2O

Direction not assertedBalancedRhea 41524

(2E)-octenoyl-[ACP] + NADH + H(+) = octanoyl-[ACP] + NAD(+)

Direction not assertedBalance undeterminableRhea 41528

(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = 3-hydroxy-L-phenylalanine + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

Direction not assertedBalancedRhea 41532

2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine = 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 41536

8-demethyl-8-alpha-L-rhamnosyl-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 41540

8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 41544

8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-methionine = 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)-tetracenomycin C + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 41548

(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = ophiobolin F + diphosphate

Direction not assertedBalancedRhea 41552

L-arginyl-[ribosomal protein uL16] + 2-oxoglutarate + O2 = (3R)-3-hydroxy-L-arginyl-[ribosomal protein uL16] + succinate + CO2

Direction not assertedBalance undeterminableRhea 41556

(3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FADH2 + O2 = (3S)-3-amino-3-(3-chloro-4,5-dihydroxyphenyl)propanoyl-[SgcC2 peptidyl-carrier protein] + FAD + H2O + H(+)

Direction not assertedBalance undeterminableRhea 41560

dTDP-beta-L-rhodosamine + aklavinone = aclacinomycin T + dTDP + 2 H(+)

Direction not assertedBalancedRhea 41564

dTDP-2-deoxy-beta-L-fucose + aclacinomycin T = aclacinomycin S + dTDP + H(+)

Direction not assertedBalancedRhea 41568

lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)

Left to rightBalancedRhea 41572

dTDP-beta-L-mycarose + erythronolide B = 3-O-alpha-L-mycarosylerythronolide B + dTDP + H(+)

Direction not assertedBalancedRhea 41576

5,10-dihydrophenazine 1-carboxylate + dimethylallyl diphosphate = 5,10-dihydro-9-dimethylallylphenazine 1-carboxylate + diphosphate

Direction not assertedBalancedRhea 41580

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