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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

651–700 of 18,558 reactions from Rhea

D-iditol + NAD(+) = keto-D-sorbose + NADH + H(+)
Direction not assertedBalancedRhea 12725
lutein = (3R,3'S)-zeaxanthin
Direction not assertedBalancedRhea 12729
nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)
Direction not assertedBalancedRhea 12733
[PrdC protein]-Se-L-selenocysteinyl-S-L-cysteine + 5-aminopentanoate = [PrdC protein]-L-selenocysteine/L-cysteine + D-proline
Direction not assertedBalance undeterminableRhea 12737
ADP + H2O + H(+) = IDP + NH4(+)
Direction not assertedBalancedRhea 12741
a 1,4-lactone + H2O = a 4-hydroxyacid + H(+)
Direction not assertedBalance undeterminableRhea 12745
3,4,5-trihydroxybenzoate + H(+) = 1,2,3-trihydroxybenzene + CO2

Direction not assertedBalancedRhea 12749

glycerol + NADP(+) = dihydroxyacetone + NADPH + H(+)

Direction not assertedBalancedRhea 12753

dihydrozeatin + NADP(+) = zeatin + NADPH + H(+)

Direction not assertedBalancedRhea 12757

precorrin-3B + S-adenosyl-L-methionine = precorrin-4 + S-adenosyl-L-homocysteine + 3 H(+)

Direction not assertedBalancedRhea 12761

2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate + CoA = 2 reduced [2Fe-2S]-[ferredoxin] + acetyl-CoA + CO2 + H(+)

Direction not assertedBalance undeterminableRhea 12765

D-gluconate + A = 2-dehydro-D-gluconate + AH2

Direction not assertedBalancedRhea 12769

proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + H2O

Direction not assertedBalancedRhea 12773

2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + chemical entity

Direction not assertedBalance undeterminableRhea 12777

an alditol + NAD(+) = an aldose + NADH + H(+)

Direction not assertedBalance undeterminableRhea 12785

an alditol + NADP(+) = an aldose + NADPH + H(+)

Right to leftBalance undeterminableRhea 12789

1D-myo-inositol hexakisphosphate + ATP = 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ADP

Direction not assertedBalancedRhea 12793

(6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 = scopolamine + succinate + CO2 + H2O + H(+)

Direction not assertedBalancedRhea 12797

L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H(+)

Left to rightBalance undeterminableRhea 12801

(S)-canadine + S-adenosyl-L-methionine = (S)-cis-N-methylcanadine + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 12805

4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O

Direction not assertedBalancedRhea 12809

L-glutamate = D-glutamate

ReversibleBalancedRhea 12813

2,3-dihydrobiochanin A + NADP(+) = biochanin A + NADPH + 2 H(+)

Direction not assertedBalancedRhea 12817

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde

Direction not assertedBalancedRhea 12821

acetyl phosphate + methylamine + [thioredoxin]-disulfide + H2O = sarcosine + [thioredoxin]-dithiol + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 12825

(2S,3S)-3-methyl-L-aspartate = mesaconate + NH4(+)

Direction not assertedBalancedRhea 12829

an N-acyl-D-glutamate + H2O = D-glutamate + a carboxylate

Direction not assertedBalance undeterminableRhea 12833

choline + ATP = phosphocholine + ADP + H(+)

Left to rightBalancedRhea 12837

pyridoxamine + pyruvate = pyridoxal + L-alanine

Direction not assertedBalancedRhea 12841

[L-4-(L-arginin-2-N-yl)aspartate](n) + H2O = [L-4-(L-arginin-2-N-yl)aspartate](n-1) + L-4-(L-arginin-2-N-yl)aspartate

Direction not assertedBalance undeterminableRhea 12845

O-phospho-L-seryl-[myosin light chain] + H2O = L-seryl-[myosin light chain] + phosphate

Direction not assertedBalance undeterminableRhea 12849

(S)-4-hydroxymandelonitrile + UDP-alpha-D-glucose = dhurrin + UDP + H(+)

Direction not assertedBalancedRhea 12853

(2S,3S)-3-methyl-L-aspartate = L-glutamate

Direction not assertedBalancedRhea 12857

guanosine + H2O + H(+) = xanthosine + NH4(+)

Direction not assertedBalancedRhea 12861

1-methyladenosine + H2O = 1-methyladenine + D-ribose

Direction not assertedBalancedRhea 12865

(2E)-geranyl diphosphate = (4S)-limonene + diphosphate

Direction not assertedBalancedRhea 12869

(2R)-hydroxy-4-methylpentanoate + NADP(+) = 4-methyl-2-oxopentanoate + NADPH + H(+)

Direction not assertedBalancedRhea 12873

acetylacetone + O2 = methylglyoxal + acetate + H(+)

Direction not assertedBalancedRhea 12877

ADP-alpha-D-glucose + sn-glycerol 3-phosphate = 2-O-(alpha-D-glucopyranosyl)-sn-glycerol 3-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 12881

queuosine(34) in tRNA(Asp) + GDP-alpha-D-mannose = O-4''-alpha-D-mannosylqueuosine(34) in tRNA(Asp) + GDP + H(+)

Left to rightBalancedRhea 12885

L-gulonate + NAD(+) = 3-dehydro-L-gulonate + NADH + H(+)

Left to rightBalancedRhea 12889

prostaglandin H2 = prostaglandin E2

Left to rightBalancedRhea 12893

2-cis-(+)-abscisate + reduced [NADPH--hemoprotein reductase] + O2 = (+)-8'-hydroxyabscisate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 12897

D-arginine + H2O = D-ornithine + urea

Direction not assertedBalancedRhea 12901

alpha-D-mannose 1-phosphate + GDP + H(+) = GDP-alpha-D-mannose + phosphate

Direction not assertedBalancedRhea 12905

2 Fe(II)-[cytochrome] + nitrate + 2 H(+) = 2 Fe(III)-[cytochrome] + nitrite + H2O

Direction not assertedBalance undeterminableRhea 12909

(R)-lipoate + ATP + H(+) = (R)-lipoyl-5'-AMP + diphosphate

Direction not assertedBalancedRhea 12913

3alpha(S)-strictosidine + H2O = strictosidine aglycone + D-glucose

Direction not assertedBalancedRhea 12917

succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

Left to rightBalancedRhea 12921

D-erythrose 4-phosphate + L-lysyl-[protein] = N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] + H2O

Direction not assertedBalance undeterminableRhea 12925

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