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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Organisms
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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

6,301–6,350 of 18,558 reactions from Rhea

7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)
Direction not assertedBalance undeterminableRhea 37119
tetracosenoyl-CoA + sphing-4-enine = N-(tetracosenoyl)-sphing-4-enine + CoA + H(+)
Left to rightBalancedRhea 37123
dioxidophosphate + 2-oxoglutarate + H2O2 = phosphonate + succinate + CO2 + H(+)
Direction not assertedBalancedRhea 37127
1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
Left to rightBalancedRhea 37131
1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z,12Z)-octadecadienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
Left to rightBalancedRhea 37135
1-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z,12Z,15Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
Left to right

→

Balanced

Rhea 37139

1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 37143

1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 37147

1-heptadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-heptadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 37151

heptadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 37155

1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 37159

1-octadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 37163

(2E,6E)-farnesol + NAD(+) = (2E,6E)-farnesal + NADH + H(+)

Direction not assertedBalancedRhea 37167

1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 37171

pentadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-pentadecanoyl-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 37175

1-(6Z,9Z,12Z-octadecatrienoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = (6Z,9Z,12Z)-octadecatrienoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 37179

1-eicosanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-eicosanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 37183

1-tetradecanoyl-sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-tetradecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 37187

2',3'-cyclophospho-AMP + H2O = adenosine 2'-phosphate + H(+)

Direction not assertedBalancedRhea 37191

sn-glycerol 3-phosphate + octadecanoyl-CoA = 1-octadecanoyl-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 37195

sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 37199

(9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphate = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 37203

(9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA

Left to rightBalancedRhea 37207

2',3'-cyclophospho-GMP + H2O = guanosine 2'-phosphate + H(+)

Direction not assertedBalancedRhea 37211

D-valine + A + H2O = 3-methyl-2-oxobutanoate + AH2 + NH4(+)

Direction not assertedBalancedRhea 37219

1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 37223

(E,E)-sorbate + H(+) = (E)-1,3-pentadiene + CO2

Direction not assertedBalancedRhea 37227

L-alaninamide + H2O = L-alanine + NH4(+)

Direction not assertedBalancedRhea 37231

2',3'-cyclophospho-UMP + H2O = uridine 2'-phosphate + H(+)

Direction not assertedBalancedRhea 37239

(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA

Left to rightBalancedRhea 37243

thymidine 3'-phosphate + H2O = thymidine + phosphate

Direction not assertedBalancedRhea 37247

cysteamine S-phosphate + H2O = cysteamine + phosphate

Direction not assertedBalancedRhea 37251

D-asparagine + A + H2O = 2-oxosuccinamate + AH2 + NH4(+)

Direction not assertedBalancedRhea 37255

(2S)-2-aminobutanoate + NAD(+) + H2O = 2-oxobutanoate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 37259

L-alanyl-L-aspartate(out) + ATP + H2O = L-alanyl-L-aspartate(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 37263

L-alanyl-L-aspartate + H2O = L-aspartate + L-alanine

Direction not assertedBalancedRhea 37267

L-alanyl-L-glutamine(out) + ATP + H2O = L-alanyl-L-glutamine(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 37271

L-alanyl-L-glutamine + H2O = L-glutamine + L-alanine

Direction not assertedBalancedRhea 37275

L-alanyl-L-histidine(out) + ATP + H2O = L-alanyl-L-histidine(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 37279

L-alanyl-L-histidine + H2O = L-histidine + L-alanine

Left to rightBalancedRhea 37283

L-alanyl-L-leucine(out) + ATP + H2O = L-alanyl-L-leucine(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 37287

L-alanyl-L-leucine + H2O = L-leucine + L-alanine

Direction not assertedBalancedRhea 37291

L-alanyl-L-threonine(out) + ATP + H2O = L-alanyl-L-threonine(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 37295

L-alanyl-L-threonine + H2O = L-threonine + L-alanine

Direction not assertedBalancedRhea 37299

glycyl-L-asparagine(out) + ATP + H2O = glycyl-L-asparagine(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 37303

glycyl-L-asparagine + H2O = L-asparagine + glycine

Direction not assertedBalancedRhea 37307

glycyl-L-glutamine(out) + ATP + H2O = glycyl-L-glutamine(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 37311

glycyl-L-glutamine + H2O = L-glutamine + glycine

Direction not assertedBalancedRhea 37315

glycyl-L-methionine(out) + ATP + H2O = glycyl-L-methionine(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 37319

glycyl-L-methionine + H2O = L-methionine + glycine

Direction not assertedBalancedRhea 37323

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