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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

5,801–5,850 of 18,558 reactions from Rhea

(S)-carnitine(out) = (S)-carnitine(in)
Direction not assertedBalancedTransportRhea 35067
4-methylphenol(in) = 4-methylphenol(out)
Direction not assertedBalancedTransportRhea 35071
doxorubicin(in) + H(+)(out) = doxorubicin(out) + H(+)(in)
Direction not assertedBalancedTransportRhea 35075
doxorubicin(in) = doxorubicin(out)
Direction not assertedBalancedTransportRhea 35079
diacetylchitobiose-6'-phosphate + H2O = N'-monoacetylchitobiose-6'-phosphate + acetate
Direction not assertedBalancedRhea 35083
N'-monoacetylchitobiose-6'-phosphate + H2O = D-glucosamine + N-acetyl-D-glucosamine 6-phosphate
Direction not assertedBalancedRhea 35087
anthranilate + L-phenylalanine + S-adenosyl-L-methionine + 2 ATP = cyclopeptine + 2 AMP + S-adenosyl-L-homocysteine + 2 diphosphate + 2 H(+)

Direction not assertedBalancedRhea 35091

choline = trimethylamine + acetaldehyde

Direction not assertedBalancedRhea 35095

fusidate(in) + H(+)(out) = fusidate(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 35099

fusidate(in) = fusidate(out)

Direction not assertedBalancedTransportRhea 35103

3-nitrotyramine + O2 + H2O = 4-hydroxy-3-nitrophenylacetaldehyde + H2O2 + NH4(+)

Direction not assertedBalancedRhea 35107

2-dehydro-L-idonate + NADP(+) = 2,5-didehydro-D-gluconate + NADPH + H(+)

Direction not assertedBalancedRhea 35111

4-coumaroyl-CoA + malonyl-CoA + H(+) = (4-coumaroyl)acetyl-CoA + CO2 + CoA

Direction not assertedBalancedRhea 35115

(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O = bisdemethoxycurcumin + CO2 + 2 CoA

Direction not assertedBalancedRhea 35119

L-alanyl-D-glutamate(out) + H(+)(out) = L-alanyl-D-glutamate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 35123

L-alanyl-D-glutamate(out) = L-alanyl-D-glutamate(in)

Direction not assertedBalancedTransportRhea 35127

L-alanyl-L-glutamate(out) + H(+)(out) = L-alanyl-L-glutamate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 35131

L-alanyl-L-glutamate(out) = L-alanyl-L-glutamate(in)

Direction not assertedBalancedTransportRhea 35135

(E)-feruloylacetyl-CoA + (E)-4-coumaroyl-CoA + H2O = demethoxycurcumin + CO2 + 2 CoA

Direction not assertedBalancedRhea 35139

benzoyl-CoA + 3 malonyl-CoA + 2 H(+) = 2,4,6-trihydroxybenzophenone + 3 CO2 + 4 CoA

Direction not assertedBalancedRhea 35143

(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(in) = (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol(out)

Direction not assertedBalancedTransportRhea 35147

4-hydroxy-3-nitrophenylacetaldehyde + NAD(+) + H2O = (3-nitro-4-oxidophenyl)acetate + NADH + 2 H(+)

Direction not assertedBalancedRhea 35151

(S)-4,5-dihydroxypentane-2,3-dione = (2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one

Direction not assertedBalancedRhea 35155

(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one + H2O = (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol

Direction not assertedBalancedRhea 35159

minocycline(in) + H(+)(out) = minocycline(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 35163

minocycline(in) = minocycline(out)

Direction not assertedBalancedTransportRhea 35167

novobiocin(in) + H(+)(out) = novobiocin(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 35171

novobiocin(in) = novobiocin(out)

Direction not assertedBalancedTransportRhea 35175

hexanoyl-[ACP] + 7 malonyl-CoA + 6 H(+) = noranthrone + holo-[ACP] + 7 CO2 + 7 CoA + 2 H2O

Direction not assertedBalance undeterminableRhea 35179

5-hydroxythiophene-2-carbonyl-CoA + H2O = 4-carboxy-2-thioxobutanoyl-CoA

Direction not assertedBalancedRhea 35183

noranthrone + O2 = norsolorinic acid + H2O

Direction not assertedBalancedRhea 35191

L-quinate(in) = L-quinate(out)

Direction not assertedBalancedTransportRhea 35195

(S,S)-tartrate(out) = (S,S)-tartrate(in)

Direction not assertedBalancedTransportRhea 35199

IDP + H2O = IMP + phosphate + H(+)

Left to rightBalancedRhea 35207

dIDP + H2O = dIMP + phosphate + H(+)

Left to rightBalancedRhea 35211

XDP + H2O = XMP + phosphate + H(+)

Direction not assertedBalancedRhea 35215

8-oxo-dADP + H2O = 8-oxo-dAMP + phosphate + H(+)

Left to rightBalancedRhea 35219

2-oxo-dADP + H2O = 2-oxo-dAMP + phosphate + H(+)

Left to rightBalancedRhea 35223

rifampicin(in) + H(+)(out) = rifampicin(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 35227

rifampicin(in) = rifampicin(out)

Direction not assertedBalancedTransportRhea 35231

tetracycline(in) + H(+)(out) = tetracycline(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 35235

tetracycline(in) = tetracycline(out)

Direction not assertedBalancedTransportRhea 35239

thiamine diphosphate + ADP + H(+) = adenosine thiamine triphosphate + phosphate

Direction not assertedBalancedRhea 35243

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(in) + ATP + H2O = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli)(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 35247

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(in) + ATP + H2O = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli)(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 35251

lipid A-core(in) + ATP + H2O = lipid A-core(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 35255

7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(in) + ATP + H2O = 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 35259

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 35263

ethanol(in) = ethanol(out)

Direction not assertedBalancedTransportRhea 35267

a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

Direction not assertedBalance undeterminableRhea 35271

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