Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

5,451–5,500 of 18,558 reactions from Rhea

tetradecanoate + ATP + CoA = tetradecanoyl-CoA + AMP + diphosphate
Left to rightBalancedRhea 33619
dodecanoate + ATP + CoA = dodecanoyl-CoA + AMP + diphosphate
Left to rightBalancedRhea 33623
decanoate + ATP + CoA = decanoyl-CoA + AMP + diphosphate
Left to rightBalancedRhea 33627
octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate
Left to rightBalancedRhea 33631
docosanoate + ATP + CoA = docosanoyl-CoA + AMP + diphosphate
Direction not assertedBalancedRhea 33635
tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate
Left to rightBalancedRhea 33639
(9Z)-tetradecenoate + ATP + CoA = (9Z)-tetradecenoyl-CoA + AMP + diphosphate
Direction not asserted

?

Balanced

Rhea 33643

(9Z)-hexadecenoate + ATP + CoA = (9Z)-hexadecenoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 33647

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 33651

(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in)

Direction not assertedBalancedTransportRhea 33655

N-tetracosanoylsphinganine + NADPH + O2 + H(+) = N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+) + H2O

Direction not assertedBalancedRhea 33659

N-hexacosanoyl-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 33663

N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 + H(+) = N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) + H2O

Direction not assertedBalancedRhea 33667

an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O = N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+)

Direction not assertedBalance undeterminableRhea 33671

N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) + H2O = N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2 + H(+)

Direction not assertedBalancedRhea 33675

N-tetracosanoylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = N-tetracosanoyl-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 33679

octadecanoyl-CoA + L-serine + H(+) = 3-oxoeicosasphinganine + CO2 + CoA

Left to rightBalancedRhea 33683

3'-N-debenzoyltaxol + benzoyl-CoA = paclitaxel + CoA + H(+)

Direction not assertedBalancedRhea 33687

2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate

Direction not assertedBalancedRhea 33691

C20 sphinganine + NADP(+) = 3-oxoeicosasphinganine + NADPH + H(+)

Direction not assertedBalancedRhea 33695

C20 sphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 33699

(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA = N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine + CoA + H(+)

Direction not assertedBalancedRhea 33703

L-threonine + ATP = O-phospho-L-threonine + ADP + H(+)

Direction not assertedBalancedRhea 33707

4-sulfomuconolactone + H2O = maleylacetate + sulfite + 2 H(+)

Direction not assertedBalancedRhea 33711

4-hydroxyeicosasphinganine 1-phosphate = 2-hydroxyoctadecanal + phosphoethanolamine

Direction not assertedBalancedRhea 33715

N-hexacosanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = N-(hexacosanoyl)-sphinganine-1-(1D-myo-inositol) + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 33719

N-tetracosanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = N-tetracosanoylsphinganine-(1D-myo-inositol) + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 33723

N-(2-hydroxyhexacosanoyl)-sphinganine + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = Ins-1-P-Cer(d18:0/2-OH-26:0) + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 33727

1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine

ReversibleBalance undeterminableRhea 33731

hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O

ReversibleBalancedRhea 33739

an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphate

Left to rightBalance undeterminableRhea 33743

a 1-acyl-sn-glycerol + ATP = a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)

Left to rightBalance undeterminableRhea 33747

a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate

Left to rightBalance undeterminableRhea 33751

N-hexadecanoyl-(4R)-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + hexadecanoate

Direction not assertedBalancedRhea 33755

a 3-oxo-fatty acyl-CoA + NADPH + H(+) = a 3-hydroxy-fatty acyl-CoA + NADP(+)

Direction not assertedBalance undeterminableRhea 33759

a (2E)-enoyl-CoA + NADPH + H(+) = a 2,3-saturated acyl-CoA + NADP(+)

Left to rightBalance undeterminableRhea 33763

a 3-hydroxy-fatty acyl-CoA = a (2E)-enoyl-CoA + H2O

Direction not assertedBalance undeterminableRhea 33767

CDP-N-methylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + CMP + H(+)

Direction not assertedBalance undeterminableRhea 33771

CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)

Direction not assertedBalance undeterminableRhea 33775

6-kestotriose + sucrose = 6,6-kestotetraose + beta-D-glucose

Direction not assertedBalancedRhea 33779

1(F)-beta-D-fructosylsucrose + sucrose = 1,6-kestotetraose + beta-D-glucose

Direction not assertedBalancedRhea 33783

3'-ketolactose + H2O = 3-keto-beta-D-galactose + beta-D-glucose

Direction not assertedBalancedRhea 33787

sucrose 6(F)-phosphate + H2O = beta-D-fructose + beta-D-glucose 6-phosphate

Direction not assertedBalancedRhea 33791

sucrose + H2O = beta-D-fructose + alpha-D-glucose

Direction not assertedBalancedRhea 33795

L-histidinol + NAD(+) = L-histidinal + NADH + H(+)

Direction not assertedBalancedRhea 33799

L-histidinal + NAD(+) + H2O = L-histidine + NADH + 2 H(+)

Direction not assertedBalancedRhea 33803

(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2

Direction not assertedBalancedRhea 33807

3 2,3-dihydroxybenzoate + 3 L-threonine + 3 glycine + 6 ATP = corynebactin + 6 AMP + 6 diphosphate + 3 H2O + 3 H(+)

Direction not assertedBalancedRhea 33811

N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CDP-glycerol = 4-O-[(2R)-glycerylphospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + CMP + H(+)

Direction not assertedBalancedRhea 33815

3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate = 3-[(1E,4R)-4-hydroxycyclohex-2-en-1-ylidene]pyruvate

Direction not assertedBalancedRhea 33819

Page 110 of 372