Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

501–550 of 18,558 reactions from Rhea

N-benzylformamide + H2O = benzylamine + formate
Direction not assertedBalancedRhea 12096
1,5-anhydro-D-fructose = microthecin + H2O
Direction not assertedBalancedRhea 12100
dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP
Left to rightBalancedRhea 12104
indole-3-pyruvate + S-adenosyl-L-methionine = (R)-3-(indol-3-yl)-2-oxobutanoate + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 12112
H2 + A = AH2
Direction not assertedBalancedRhea 12116
alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate
Direction not assertedBalancedRhea 12120
shikimate + 4-coumaroyl-CoA = trans-4-coumaroylshikimate + CoA

? Direction not asserted

Balanced

Rhea 12124

2 oxidized [2Fe-2S]-[ferredoxin] + 2 L-glutamate = L-glutamine + 2 reduced [2Fe-2S]-[ferredoxin] + 2-oxoglutarate + 2 H(+)

Direction not assertedBalance undeterminableRhea 12128

Cd(2+)(in) + ATP + H2O = Cd(2+)(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 12132

a 4,5-saturated-(2E)-enoyl-CoA + NADP(+) = a (2E,4E)-dienoyl-CoA + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 12136

a 2'-deoxyribonucleoside + ATP = a 2'-deoxyribonucleoside 5'-phosphate + ADP + H(+)

Direction not assertedBalance undeterminableRhea 12140

cyanidin 3-O-rutinoside + UDP-alpha-D-glucose = cyanidin 3-O-rutinoside 5-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 12144

(3R,4S,5S,6R)-pentachlorocyclohexene = (3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + chloride + H(+)

Direction not assertedBalancedRhea 12152

2-glutathionyl-2-methylbut-3-en-1-ol + 2 NAD(+) + H2O = 2-glutathionyl-2-methylbut-3-enoate + 2 NADH + 3 H(+)

Direction not assertedBalancedRhea 12156

2-deoxy-D-gluconate + NAD(+) = 3-dehydro-2-deoxy-D-gluconate + NADH + H(+)

Direction not assertedBalancedRhea 12160

a phenol + 3'-phosphoadenylyl sulfate = an aryl sulfate + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalance undeterminableRhea 12164

allyl alcohol + NADP(+) = acrolein + NADPH + H(+)

Direction not assertedBalancedRhea 12168

alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)

ReversibleBalancedRhea 12172

phenylethanolamine + S-adenosyl-L-methionine = N-methylphenylethanolamine + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 12176

anthranilate + S-adenosyl-L-methionine = N-methylanthranilate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 12180

(S,S)-butane-2,3-diol + NAD(+) = (S)-acetoin + NADH + H(+)

Direction not assertedBalancedRhea 12184

N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2

Left to rightBalance undeterminableRhea 12188

(2E,6E)-farnesyl diphosphate + H2O = (+)-(1(10)E,4E,6S,7R)-germacradien-6-ol + diphosphate

Direction not assertedBalancedRhea 12192

keto-D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O

Direction not assertedBalancedRhea 12196

2'-deoxymugineate + 2-oxoglutarate + O2 = mugineate + succinate + CO2

Direction not assertedBalancedRhea 12200

dihydromonacolin L carboxylate + reduced [NADPH--hemoprotein reductase] + O2 = 3alpha-hydroxy-3,5-dihydromonacolin L carboxylate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 12204

4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

Direction not assertedBalancedRhea 12208

9H-fluoren-9-ol + NADP(+) = 9H-fluoren-9-one + NADPH + H(+)

Direction not assertedBalancedRhea 12212

9H-fluoren-9-ol + NAD(+) = 9H-fluoren-9-one + NADH + H(+)

Direction not assertedBalancedRhea 12216

L-leucine + NAD(+) + H2O = 4-methyl-2-oxopentanoate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 12220

L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 12228

acetyl phosphate + [thioredoxin]-disulfide + NH4(+) + H2O = [thioredoxin]-dithiol + glycine + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 12232

nicotinate + NADP(+) + H2O = 6-hydroxynicotinate + NADPH + H(+)

Direction not assertedBalancedRhea 12236

3 malonyl-CoA + acetyl-CoA + NADPH + 3 H(+) = 6-methylsalicylate + 3 CO2 + NADP(+) + 4 CoA + H2O

Direction not assertedBalancedRhea 12240

UDP-N-acetyl-alpha-D-muramate + NADP(+) = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH + H(+)

Direction not assertedBalancedRhea 12248

4-O-(beta-D-glucosyl)-(E)-coniferol + H2O = (E)-coniferol + D-glucose

Direction not assertedBalancedRhea 12252

L-arogenate + NAD(+) = L-tyrosine + CO2 + NADH

Direction not assertedBalancedRhea 12256

NADH + ATP = ADP + NADPH + H(+)

Direction not assertedBalancedRhea 12260

putrescine + 2-oxoglutarate = 1-pyrroline + L-glutamate + H2O

Direction not assertedBalancedRhea 12268

L-dopa + H(+) = dopamine + CO2

Direction not assertedBalancedRhea 12272

3-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 3-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]

Left to rightBalance undeterminableRhea 12276

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)

Left to rightBalance undeterminableRhea 12280

3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate

ReversibleBalancedRhea 12284

an alpha-L-fucoside + H2O = L-fucose + an alcohol

Left to rightBalance undeterminableRhea 12288

tRNA(Ser) + L-serine + ATP = L-seryl-tRNA(Ser) + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 12292

deacetylipecoside + H2O = secologanin + dopamine

Direction not assertedBalancedRhea 12296

uridine(47) in tRNA(Phe) + S-adenosyl-L-methionine = 3-[(3S)-3-amino-3-carboxypropyl]uridine(47) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)

Direction not assertedBalance undeterminableRhea 12300

(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 12304

(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)

Left to rightBalancedRhea 12308

dibenzothiophene 5,5-dioxide + FMNH2 + NADH + O2 = 2'-hydroxybiphenyl-2-sulfinate + FMN + NAD(+) + H2O + H(+)

Direction not assertedBalancedRhea 12312

Page 11 of 372