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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

Chemistry

Reactions
Reach

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Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

451–500 of 18,558 reactions from Rhea

6-O-methylnorlaudanosoline + S-adenosyl-L-methionine = nororientaline + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 11892
7alpha-hydroxycholesterol + NAD(+) = 7alpha-hydroxycholest-4-en-3-one + NADH + H(+)
Left to rightBalancedRhea 11896
(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH
Direction not assertedBalancedRhea 11900
2-amino-4-hydroxypteridine + H2O + H(+) = 2,4-dihydroxypteridine + NH4(+)
Direction not assertedBalancedRhea 11904
nonane-4,6-dione + H2O = pentan-2-one + butanoate + H(+)
Direction not assertedBalancedRhea 11908
13,14-dihydro-15-oxo-prostaglandin E2 + NADP(+) = 15-oxoprostaglandin E2 + NADPH + H(+)
Right to leftBalancedRhea 11912
13,14-dihydro-15-oxo-prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)

Right to leftBalancedRhea 11916

(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O

Direction not assertedBalancedRhea 11920

a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a globoside Gb3Cer (d18:1(4E)) + UDP + H(+)

Left to rightBalance undeterminableRhea 11924

hydroxylamine + NH4(+) = hydrazine + H2O + H(+)

Direction not assertedBalancedRhea 11928

2-hydroxy-2-methylpropanenitrile = acetone + hydrogen cyanide

Direction not assertedBalancedRhea 11932

4-coumaroyl-CoA + 3 malonyl-CoA + 3 H(+) = trans-resveratrol + 4 CO2 + 4 CoA

Direction not assertedBalancedRhea 11936

L-citrulline + H2O + 2 H(+) = L-ornithine + NH4(+) + CO2

Direction not assertedBalancedRhea 11940

(3R,6R)-1,3,4,6-tetrachlorocyclohexa-1,4-diene + 2 H2O = 2,5-dichlorocyclohexa-2,5-dien-1,4-diol + 2 chloride + 2 H(+)

Direction not assertedBalancedRhea 11944

4-hydroxybenzoyl-CoA + H2O = 4-hydroxybenzoate + CoA + H(+)

Direction not assertedBalancedRhea 11948

3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate

Direction not assertedBalancedRhea 11952

cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose

Left to rightBalancedRhea 11956

N-succinyl-(2S,6S)-2,6-diaminopimelate + 2-oxoglutarate = (S)-2-succinylamino-6-oxoheptanedioate + L-glutamate

Direction not assertedBalancedRhea 11960

5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol

Left to rightBalancedRhea 11964

kynurenate + AH2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + A

Direction not assertedBalancedRhea 11968

4 Fe(2+) + O2 + 6 H2O = 4 iron(III) oxide-hydroxide + 12 H(+)

Direction not assertedBalancedRhea 11972

anhydrotetracycline + NADPH + O2 + H(+) = 5a,11a-dehydrotetracycline + NADP(+) + H2O

Direction not assertedBalancedRhea 11976

2 gamma-L-glutamyl-L-cysteine + NADP(+) = bis-gamma-glutamylcystine + NADPH + H(+)

Direction not assertedBalancedRhea 11980

progesterone + AH2 + O2 = testosterone acetate + A + H2O

Direction not assertedBalancedRhea 11984

a 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = a 1-acyl-2-(9-cyclopronane)-acyl-sn-glycero-3-phospholipid + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 11988

L-pipecolate + O2 = L-1-piperideine-6-carboxylate + H2O2 + H(+)

Direction not assertedBalancedRhea 11992

biphenyl-2-ol + NADH + O2 + H(+) = biphenyl-2,3-diol + NAD(+) + H2O

Direction not assertedBalancedRhea 11996

formate + NADP(+) = CO2 + NADPH

Direction not assertedBalancedRhea 12000

indoxyl + UDP-alpha-D-glucose = indican + UDP + H(+)

Direction not assertedBalancedRhea 12004

[G protein-coupled receptor] + ATP = [G protein-coupled receptor]-phosphate + ADP + H(+)

Left to rightBalance undeterminableRhea 12008

thiamine + ATP = thiamine phosphate + ADP + H(+)

Direction not assertedBalancedRhea 12012

(2E,6E)-farnesyl diphosphate = (-)-germacrene D + diphosphate

Direction not assertedBalancedRhea 12016

a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)

Direction not assertedBalance undeterminableRhea 12020

1-O-(trans-sinapoyl)-beta-D-glucose + choline = O-sinapoylcholine + D-glucose

Direction not assertedBalancedRhea 12024

L-5-carboxymethylhydantoin + H2O = N-carbamoyl-L-aspartate + H(+)

Direction not assertedBalancedRhea 12028

a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)

Direction not assertedBalance undeterminableRhea 12032

(S)-3-(imidazol-5-yl)lactate + NAD(+) = 3-(imidazol-5-yl)pyruvate + NADH + H(+)

Direction not assertedBalancedRhea 12036

(S)-3-(imidazol-5-yl)lactate + NADP(+) = 3-(imidazol-5-yl)pyruvate + NADPH + H(+)

Direction not assertedBalancedRhea 12040

a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 12044

3-oxoadipate + succinyl-CoA = 3-oxoadipyl-CoA + succinate

Direction not assertedBalancedRhea 12048

(2E,6E)-farnesyl diphosphate = trichodiene + diphosphate

Direction not assertedBalancedRhea 12052

D-erythrose 4-phosphate + NAD(+) + H2O = 4-phospho-D-erythronate + NADH + 2 H(+)

Direction not assertedBalancedRhea 12056

6 malonyl-CoA + acetyl-CoA + 5 H(+) = 3,6,7,9-tetrahydroxy-3-methyl-2,3-dihydro-1H-naphtho[2,1-b]pyran-1-one + 6 CO2 + 7 CoA + H2O

Direction not assertedBalancedRhea 12060

apo-[ACP] + CoA = holo-[ACP] + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalance undeterminableRhea 12068

an (S)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)

Direction not assertedBalance undeterminableRhea 12072

an aromatic primary alcohol + NAD(+) = an aromatic aldehyde + NADH + H(+)

Direction not assertedBalance undeterminableRhea 12076

malonyl-[ACP] + acetyl-CoA + H(+) = 3-oxobutanoyl-[ACP] + CO2 + CoA

Direction not assertedBalance undeterminableRhea 12080

D-mannitol + NAD(+) = D-fructose + NADH + H(+)

Direction not assertedBalancedRhea 12084

an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

Left to rightBalance undeterminableRhea 12088

(S)-acetoin = (R)-acetoin

Direction not assertedBalancedRhea 12092

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