Proteins/UNIPROT:Q9ULT6

ZNRF3

ProteinUNIPROT:Q9ULT6

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity)..

Function from UniProtKB (Q9ULT6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

complex neurodevelopmental disorder has a germline basis in ZNRF3DiseaseGenCC HGNC:18126|MONDO:0100038Inferred only

Statements

12 statements

12 statements · 3 reference databases · Subject: ZNRF3 · Sources: gene ontology, Hetionet, Reactome

Order

OR1N2 covaries with ZNRF3ProteinHetionet hetionet:covaries:138882-84133Inferred only
OR4K15 covaries with ZNRF3ProteinHetionet hetionet:covaries:81127-84133Inferred only
GFI1B interacts with ZNRF3ProteinHetionet hetionet:interacts:8328-84133Inferred only
LRP6 interacts with ZNRF3ProteinHetionet hetionet:interacts:4040-84133Inferred only
UBE2N interacts with ZNRF3ProteinHetionet hetionet:interacts:7334-84133Inferred only
ZNRF3 participates in Regulation of FZD by ubiquitinationPathwayReactome R-HSA-4641263Inferred only
ZNRF3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ZNRF3 participates in Signaling by WNTPathwayReactome R-HSA-195721Inferred only
ZNRF3 participates in TCF dependent signaling in response to WNTPathwayReactome R-HSA-201681Inferred only
ZNRF3 regulates negative regulation of canonical Wnt signaling pathwayBiological processgene ontology Q9ULT6|GO:0090090Inferred only
ZNRF3 regulates negative regulation of non-canonical Wnt signaling pathwayBiological processgene ontology Q9ULT6|GO:2000051Inferred only
ZNRF3 regulates regulation of Wnt signaling pathway, planar cell polarity pathwayBiological processgene ontology Q9ULT6|GO:2000095Inferred only

Other names

5 names

Resolves to: ZNRF3

Also called: KIAA1133RING finger protein 203RING-type E3 ubiquitin transferase ZNRF3RNF203Zinc/RING finger protein 3

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