Proteins/UNIPROT:Q8TF32

ZNF431

ProteinUNIPROT:Q8TF32

Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity)..

Function from UniProtKB (Q8TF32), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

11 statements

11 statements · 3 reference databases · Subject: ZNF431 · Sources: gene ontology, Hetionet, Reactome

Order

ANXA7 interacts with ZNF431ProteinHetionet hetionet:interacts:170959-310Inferred only
CDKN1A interacts with ZNF431ProteinHetionet hetionet:interacts:1026-170959Inferred only
SMN1; SMN2 interacts with ZNF431ProteinHetionet hetionet:interacts:170959-6606Inferred only
SMN1; SMN2 interacts with ZNF431ProteinHetionet hetionet:interacts:170959-6607Inferred only
TK1 interacts with ZNF431ProteinHetionet hetionet:interacts:170959-7083Inferred only
UBC interacts with ZNF431ProteinHetionet hetionet:interacts:170959-7316Inferred only
ZNF431 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
ZNF431 participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
ZNF431 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
ZNF431 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q8TF32|GO:0000122Inferred only
ZNF431 regulates regulation of DNA-templated transcriptionBiological processgene ontology Q8TF32|GO:0006355Inferred only

Other names

2 names

Resolves to: ZNF431

Also called: KIAA1969Zinc finger protein 431

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