Proteins/UNIPROT:Q9BRR0

ZKSCAN3

ProteinUNIPROT:Q9BRR0

Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migration in various tumors and myelomas..

Function from UniProtKB (Q9BRR0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

15 statements

15 statements · 3 reference databases · Subject: ZKSCAN3 · Sources: gene ontology, Hetionet, Reactome

Order

ZKSCAN3 covaries with BCANProteinHetionet hetionet:covaries:63827-80317Inferred only
ECHDC1 covaries with ZKSCAN3ProteinHetionet hetionet:covaries:55862-80317Inferred only
ZKSCAN3 covaries with LCA5LProteinHetionet hetionet:covaries:150082-80317Inferred only
NR4A3 covaries with ZKSCAN3ProteinHetionet hetionet:covaries:8013-80317Inferred only
ZKSCAN3 covaries with SMG5ProteinHetionet hetionet:covaries:23381-80317Inferred only
GRB2 interacts with ZKSCAN3ProteinHetionet hetionet:interacts:2885-80317Inferred only
ZKSCAN3 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
ZKSCAN3 participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
ZKSCAN3 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
ZKSCAN3 regulates negative regulation of autophagyBiological processgene ontology Q9BRR0|GO:0010507Inferred only
ZKSCAN3 regulates negative regulation of cellular senescenceBiological processgene ontology Q9BRR0|GO:2000773Inferred only
ZKSCAN3 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q9BRR0|GO:0045892Inferred only

Show the remaining 3

ZKSCAN3 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q9BRR0|GO:0000122Inferred only
ZKSCAN3 regulates positive regulation of DNA-templated transcriptionBiological processgene ontology Q9BRR0|GO:0045893Inferred only
ZKSCAN3 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q9BRR0|GO:0006357Inferred only

Other names

10 names

Resolves to: ZKSCAN3

Also called: Zf47Zfp-47ZFP47Zinc finger and SCAN domain-containing protein 13Zinc finger protein 306Zinc finger protein 309Zinc finger protein 47 homologZNF306ZNF309ZSCAN13

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