Proteins/UNIPROT:Q9UPR3

SMG5

ProteinUNIPROT:Q9UPR3

Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity..

Function from UniProtKB (Q9UPR3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 3 reference databases · Subject: SMG5 · Sources: gene ontology, Hetionet, Reactome

Order

ZKSCAN3 covaries with SMG5ProteinHetionet hetionet:covaries:23381-80317Inferred only
APP interacts with SMG5ProteinHetionet hetionet:interacts:23381-351Inferred only
SMG1 interacts with SMG5ProteinHetionet hetionet:interacts:23049-23381Inferred only
SMG6 interacts with SMG5ProteinHetionet hetionet:interacts:23293-23381Inferred only
STUB1 interacts with SMG5ProteinHetionet hetionet:interacts:10273-23381Inferred only
TERT interacts with SMG5ProteinHetionet hetionet:interacts:23381-7015Inferred only
UBC interacts with SMG5ProteinHetionet hetionet:interacts:23381-7316Inferred only
UPF1 interacts with SMG5ProteinHetionet hetionet:interacts:23381-5976Inferred only
SMG5 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
SMG5 participates in Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)PathwayReactome R-HSA-975957Inferred only
SMG5 participates in Nonsense-Mediated Decay (NMD)PathwayReactome R-HSA-927802Inferred only
SMG5 regulates regulation of dephosphorylationBiological processgene ontology Q9UPR3|GO:0035303Inferred only

Show the remaining 4

SMG5 regulates regulation of telomere maintenanceBiological processgene ontology Q9UPR3|GO:0032204Inferred only
SMG5 regulates regulation of telomere maintenance via telomeraseBiological processgene ontology Q9UPR3|GO:0032210Inferred only
DMAC2L increases the expression of SMG5ProteinHetionet hetionet:regulates:27109-23381Inferred only
KMT2A increases the expression of SMG5ProteinHetionet hetionet:regulates:4297-23381Inferred only

Other names

7 names

Resolves to: SMG5

Also called: EST1-like protein BEST1BhSMG-5KIAA1089LPTS-interacting proteinLPTS-RP1SMG-5 homolog

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