ZFYVE27

Molecular tethering protein, which plays a role in the formation of membrane contact sites between the endoplasmic reticulum and late endosomes/lysosomes. Promotes neurite formation by tethering endosomes to the endoplasmic reticulum membrane: interacts with Rab7-positive late endosomes, acting as a bridge to form endoplasmic reticulum membrane-endosome contact sites. Acts in cooperation with vesicle-associated membrane protein-associated protein (VAPA or VAPB), thereby facilitating loading of the endosome membrane with KIF5, which is required for movement of the endosomes along microtubules in the plus-end direction. Also associates with Rab11-positive recycling endosomes, facilitating exocytosis and membrane expansion. Contributes to both the formation and stabilization of the tubular endoplasmic reticulum network. Involved in endoplasmic reticulum morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections..

Function from UniProtKB (Q5T4F4), read 2026-09-23. CC BY 4.0.