Proteins/UNIPROT:P09544

WNT2

ProteinUNIPROT:P09544

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Functions as a upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity)..

Function from UniProtKB (P09544), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

36 statements

36 statements · 4 reference databases · Subject: WNT2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

AQP5 interacts with WNT2ProteinHetionet hetionet:interacts:362-7472Inferred only
WNT2 interacts with FZD1ProteinHetionet hetionet:interacts:7472-8321Inferred only
WNT2 interacts with FZD9ProteinHetionet hetionet:interacts:7472-8326Inferred only
HCK interacts with WNT2ProteinHetionet hetionet:interacts:3055-7472Inferred only
WNT2 interacts with RRAGCProteinHetionet hetionet:interacts:64121-7472Inferred only
SFRP1 interacts with WNT2ProteinHetionet hetionet:interacts:6422-7472Inferred only
WNT2 interacts with UQCR11ProteinHetionet hetionet:interacts:10975-7472Inferred only
WNT2 interacts with WNT3AProteinHetionet hetionet:interacts:7472-89780Inferred only
WNT2 participates in 7q11 23 copy number variation syndromePathwayWikiPathways WP4932Inferred only
WNT2 participates in Alzheimer 39 s diseasePathwayWikiPathways WP5124Inferred only
WNT2 participates in Alzheimer 39 s disease and miRNA effectsPathwayWikiPathways WP2059Inferred only
WNT2 participates in Amplification and expansion of oncogenic pathways as metastatic traitsPathwayWikiPathways WP3678Inferred only

Show the remaining 24

WNT2 participates in Breast cancer pathwayPathwayWikiPathways WP4262Inferred only
WNT2 participates in Cancer pathwaysPathwayWikiPathways WP5434Inferred only
WNT2 participates in Class B/2 (Secretin family receptors)PathwayReactome R-HSA-373080Inferred only
WNT2 participates in DNA damage response only ATM dependent PathwayWikiPathways WP710Inferred only
WNT2 participates in Embryonic stem cell pluripotency pathwaysPathwayWikiPathways WP3931Inferred only
WNT2 participates in Epithelial to mesenchymal transition in colorectal cancerPathwayWikiPathways WP4239Inferred only
WNT2 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
WNT2 participates in lncRNA in canonical Wnt signaling and colorectal cancerPathwayWikiPathways WP4258Inferred only
WNT2 participates in ncRNAs in Wnt signaling in hepatocellular carcinomaPathwayWikiPathways WP4336Inferred only
WNT2 participates in Osteoblast differentiation and related diseasesPathwayWikiPathways WP4787Inferred only
WNT2 participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
WNT2 participates in Pluripotent stem cell differentiation pathwayPathwayWikiPathways WP2848Inferred only
WNT2 participates in Polycystic kidney disease pathwayPathwayWikiPathways WP2571Inferred only
WNT2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
WNT2 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
WNT2 participates in Signaling by WNTPathwayReactome R-HSA-195721Inferred only
WNT2 participates in WNT ligand biogenesis and traffickingPathwayReactome R-HSA-3238698Inferred only
WNT2 participates in Wnt signalingPathwayWikiPathways WP428Inferred only
WNT2 participates in Wnt signaling and pluripotencyPathwayWikiPathways WP399Inferred only
WNT2 participates in Wnt signaling in kidney diseasePathwayWikiPathways WP4150Inferred only
WNT2 regulates positive regulation of cell population proliferationBiological processgene ontology P09544|GO:0008284Inferred only
WNT2 regulates positive regulation of fibroblast proliferationBiological processgene ontology P09544|GO:0048146Inferred only
WNT2 regulates positive regulation of neurogenesisBiological processgene ontology P09544|GO:0050769Inferred only
WNT2 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology P09544|GO:0045944Inferred only

Other names

4 names

Resolves to: WNT2

Also called: Int-1-like protein 1Int-1-related proteinINT1L1IRP

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