Proteins/UNIPROT:Q5VIR6

VPS53

ProteinUNIPROT:Q5VIR6

Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane..

Function from UniProtKB (Q5VIR6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

pontocerebellar hypoplasia type 2E has a germline basis in VPS53DiseaseGenCC HGNC:25608|MONDO:0014370Inferred only
pontocerebellar hypoplasia, type 13 has a germline basis in VPS53DiseaseGenCC HGNC:25608|MONDO:0032831Inferred only

Statements

10 statements

10 statements · 2 reference databases · Subject: VPS53 · Sources: Hetionet, Reactome

Order

VPS53 covaries with DMDProteinHetionet hetionet:covaries:1756-55275Inferred only
VPS53 interacts with EXOC2ProteinHetionet hetionet:interacts:55275-55770Inferred only
UBC interacts with VPS53ProteinHetionet hetionet:interacts:55275-7316Inferred only
VCP interacts with VPS53ProteinHetionet hetionet:interacts:55275-7415Inferred only
VPS51 interacts with VPS53ProteinHetionet hetionet:interacts:55275-738Inferred only
VPS52 interacts with VPS53ProteinHetionet hetionet:interacts:55275-6293Inferred only
VPS53 participates in Intra-Golgi and retrograde Golgi-to-ER trafficPathwayReactome R-HSA-6811442Inferred only
VPS53 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
VPS53 participates in Retrograde transport at the Trans-Golgi-NetworkPathwayReactome R-HSA-6811440Inferred only
VPS53 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only

Other names

1 name

Resolves to: VPS53

Also called: Vacuolar protein sorting-associated protein 53 homolog

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