Proteins/UNIPROT:O75351

VPS4B

ProteinUNIPROT:O75351

Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their ATP-dependent disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan..

(Microbial infection) In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses)..

Function from UniProtKB (O75351), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

dentin dysplasia type I has a germline basis in VPS4BDiseaseGenCC HGNC:10895|MONDO:0007436Inferred only

Statements

27 statements

27 statements · 3 reference databases · Subject: VPS4B · Sources: gene ontology, Hetionet, Reactome

Order

CHMP1A interacts with VPS4BProteinHetionet hetionet:interacts:5119-9525Inferred only
VPS4B interacts with CHMP1BProteinHetionet hetionet:interacts:57132-9525Inferred only
VPS4B interacts with CHMP2AProteinHetionet hetionet:interacts:27243-9525Inferred only
CUL3 interacts with VPS4BProteinHetionet hetionet:interacts:8452-9525Inferred only
VPS4B interacts with HTRA2ProteinHetionet hetionet:interacts:27429-9525Inferred only
VPS4B interacts with PDCD6IPProteinHetionet hetionet:interacts:10015-9525Inferred only
UBC interacts with VPS4BProteinHetionet hetionet:interacts:7316-9525Inferred only
VPS4B interacts with VPS4AProteinHetionet hetionet:interacts:27183-9525Inferred only
VPS4B participates in Budding and maturation of HIV virionPathwayReactome R-HSA-162588Inferred only
VPS4B participates in DiseasePathwayReactome R-HSA-1643685Inferred only
VPS4B participates in Endosomal Sorting Complex Required For Transport (ESCRT)PathwayReactome R-HSA-917729Inferred only
VPS4B participates in HIV InfectionPathwayReactome R-HSA-162906Inferred only

Show the remaining 15

VPS4B participates in HIV Life CyclePathwayReactome R-HSA-162587Inferred only
VPS4B participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
VPS4B participates in Late Phase of HIV Life CyclePathwayReactome R-HSA-162599Inferred only
VPS4B participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
VPS4B participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
VPS4B participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
VPS4B regulates negative regulation of exosomal secretionBiological processgene ontology O75351|GO:1903542Inferred only
VPS4B regulates positive regulation of centriole elongationBiological processgene ontology O75351|GO:1903724Inferred only
VPS4B regulates positive regulation of exosomal secretionBiological processgene ontology O75351|GO:1903543Inferred only
VPS4B regulates positive regulation of G2/M transition of mitotic cell cycleBiological processgene ontology O75351|GO:0010971Inferred only
VPS4B regulates regulation of centrosome duplicationBiological processgene ontology O75351|GO:0010824Inferred only
VPS4B regulates regulation of mitotic spindle assemblyBiological processgene ontology O75351|GO:1901673Inferred only
CNDP2 decreases the expression of VPS4BProteinHetionet hetionet:regulates:55748-9525Inferred only
RBKS increases the expression of VPS4BProteinHetionet hetionet:regulates:64080-9525Inferred only
RPA1 increases the expression of VPS4BProteinHetionet hetionet:regulates:6117-9525Inferred only

Reactions

1 reaction

ATP(4-)+waterADP(3-)+hydrogenphosphate+hydron
Catalysed by HFM1 or SMCHD1 or FIGNL2 or DDX39A or DDX3X or CHD1 or CHD2 or TOR1A or TOR1B or DDX3Y or DHX15 or GET3 and 193 more alternatives

Other names

5 names

Resolves to: VPS4B

Also called: Cell migration-inducing gene 1 proteinProtein SKD1SKD1Suppressor of K(+) transport growth defect 1VPS42

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