Proteins/UNIPROT:Q70CQ1

USP49

ProteinUNIPROT:Q70CQ1

Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub), a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Antagonizes DNA double-strand break-induced ubiquitination of H2AX thereby participating in the maintenance of genome integrity. Plays a role in the negative regulation of cell proliferation through the AKT pathway by deubiquitinating FKBP51, leading to enhanced AKT1 dephosphorylation by PHLPP1. Also regulates the mitotic spindle checkpoint and prevents aneuploidy. Negatively regulates cellular antiviral responses via deconjugating 'Lys-63'-linked ubiquitination of STING1. Significantly enhances the anti-HIV-1 activity of APOBEC3G. Mechanistically, stabilizes APOBEC3G by counteracting HIV-1 Vif-mediated APOBEC3G ubiquitination..

Function from UniProtKB (Q70CQ1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

11 statements

11 statements · 3 reference databases · Subject: USP49 · Sources: gene ontology, Hetionet, Reactome

Order

USP49 covaries with CDX1ProteinHetionet hetionet:covaries:1044-25862Inferred only
MED17 interacts with USP49ProteinHetionet hetionet:interacts:25862-9440Inferred only
USP49 interacts with MED18ProteinHetionet hetionet:interacts:25862-54797Inferred only
USP49 interacts with MED8ProteinHetionet hetionet:interacts:112950-25862Inferred only
RBCK1 interacts with USP49ProteinHetionet hetionet:interacts:10616-25862Inferred only
TRIM35 interacts with USP49ProteinHetionet hetionet:interacts:23087-25862Inferred only
USP49 participates in DeubiquitinationPathwayReactome R-HSA-5688426Inferred only
USP49 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
USP49 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
USP49 participates in Ub-specific processing proteasesPathwayReactome R-HSA-5689880Inferred only
USP49 regulates negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionBiological processgene ontology Q70CQ1|GO:0051898Inferred only

Reactions

1 reaction

water+MAM03104cproton+a thiol+MAM03105c
Catalysed by USP2 or USP28 or USP36 or USP13 or OTUD5 or USP33 or CYLD or USP40 or USP48 or USP14 or USP10 or USP31 and 43 more alternatives
Reaction pageLeft to rightBalance undeterminable

Other names

3 names

Resolves to: USP49

Also called: Deubiquitinating enzyme 49Ubiquitin thioesterase 49Ubiquitin-specific-processing protease 49

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