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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q70EL4

USP43

Protein·UNIPROT:Q70EL4

Open in the graph

May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity)..

Function from UniProtKB (Q70EL4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

5 statements

5 statements · 2 reference databases · Subject: USP43 · Sources: Hetionet, Reactome

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USP43 covaries with HOXC10ProteinHetionet hetionet:covaries:124739-3226Inferred only
USP43 participates in DNA Damage BypassPathwayReactome R-HSA-73893Inferred only
USP43 participates in DNA RepairPathwayReactome R-HSA-73894Inferred only
USP43 participates in Termination of translesion DNA synthesisPathwayReactome R-HSA-5656169Inferred only
USP43 participates in Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templatePathwayReactome R-HSA-110313Inferred only

Reactions

1 reaction

water+MAM03104cproton+a thiol+MAM03105c
Catalysed by USP2 or USP28 or USP36 or USP13 or OTUD5 or USP33 or CYLD or USP40 or USP48 or USP14 or USP10 or USP31 and 43 more alternatives
Reaction pageLeft to rightBalance undeterminable

Other names

3 names

Resolves to: USP43

Also called: Deubiquitinating enzyme 43Ubiquitin thioesterase 43Ubiquitin-specific-processing protease 43

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EC 3.4.19.12

cytosol

Human-GEM MAR09490CC BY 4.0Reference data