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Proteins/UNIPROT:Q70CQ3

USP30

Protein·UNIPROT:Q70CQ3

Open in the graph

Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65'. Acts as a negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity)..

Function from UniProtKB (Q70CQ3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

1 statement

1 statement · 1 reference database · Subject: USP30 · Sources: Hetionet

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UBC interacts with USP30ProteinHetionet hetionet:interacts:7316-84749Inferred only

Reactions

1 reaction

water+MAM03104cproton+a thiol+MAM03105c
Catalysed by USP2 or USP28 or USP36 or USP13 or OTUD5 or USP33 or CYLD or USP40 or USP48 or USP14 or USP10 or USP31 and 43 more alternatives
Reaction pageLeft to rightBalance undeterminable

Other names

4 names

Resolves to: USP30

Also called: Deubiquitinating enzyme 30Ub-specific protease 30Ubiquitin thioesterase 30Ubiquitin-specific-processing protease 30

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EC 3.4.19.12

GO:0005829

Human-GEM MAR09490CC BY 4.0Reference data