Proteins/UNIPROT:Q9BXU7

USP26

ProteinUNIPROT:Q9BXU7

Deubiquitinase regulating several biological processes through the deubiquitination of components of these processes. Involved in somatic cell reprogramming through the 'Lys-48'-linked deubiquitination and stabilization of CBX4 and CBX6, two components of the polycomb-repressive complex 1 (PRC1). Also deubiquitinates and probably stabilizes the androgen receptor (AR), regulating the androgen receptor signaling pathway. May play a role in spermatogenesis..

Function from UniProtKB (Q9BXU7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

13 statements

13 statements · 4 reference databases · Subject: USP26 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

USP26 covaries with BRD8ProteinHetionet hetionet:covaries:10902-83844Inferred only
USP26 covaries with CEP192ProteinHetionet hetionet:covaries:55125-83844Inferred only
USP26 covaries with CHAMP1ProteinHetionet hetionet:covaries:283489-83844Inferred only
USP26 covaries with MBNL3ProteinHetionet hetionet:covaries:55796-83844Inferred only
USP26 covaries with SCML1ProteinHetionet hetionet:covaries:6322-83844Inferred only
USP26 interacts with USP17L7ProteinHetionet hetionet:interacts:392197-83844Inferred only
USP26 participates in DeubiquitinationPathwayReactome R-HSA-5688426Inferred only
USP26 participates in Male infertilityPathwayWikiPathways WP4673Inferred only
USP26 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
USP26 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
USP26 participates in Ub-specific processing proteasesPathwayReactome R-HSA-5689880Inferred only
USP26 regulates negative regulation of proteasomal ubiquitin-dependent protein catabolic processBiological processgene ontology Q9BXU7|GO:0032435Inferred only

Show the remaining 1

USP26 regulates regulation of androgen receptor signaling pathwayBiological processgene ontology Q9BXU7|GO:0060765Inferred only

Reactions

1 reaction

water+MAM03104cproton+a thiol+MAM03105c
Catalysed by USP2 or USP28 or USP36 or USP13 or OTUD5 or USP33 or CYLD or USP40 or USP48 or USP14 or USP10 or USP31 and 43 more alternatives
Reaction pageLeft to rightBalance undeterminable

Other names

3 names

Resolves to: USP26

Also called: Deubiquitinating enzyme 26Ubiquitin thioesterase 26Ubiquitin-specific-processing protease 26

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