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Proteins/UNIPROT:Q96N76

UROC1

Protein·UNIPROT:Q96N76

Open in the graph

Catalyzes the conversion of trans-urocanate to 4-imidazolone-5-propionate, the second step in histidine catabolism..

Function from UniProtKB (Q96N76), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

urocanic aciduria has a germline basis in UROC1DiseaseGenCC HGNC:26444|MONDO:0010167Inferred only

Statements

2 statements

2 statements · 2 reference databases · Subject: UROC1 · Sources: Hetionet, Human-GEM

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SUMO1 interacts with UROC1ProteinHetionet hetionet:interacts:131669-7341Inferred only
trans-urocanate is a substrate of UROC1CompoundHuman-GEM MAR04712Inferred only

Reactions

2 reactions

water+trans-urocanateMAM01009c
Catalysed by UROC1
Reaction pageLeft to rightBalancedEC 4.2.1.49GO:0005829
Human-GEM MAR04712CC BY 4.0Reference data
CHEBI:77893trans-urocanate+water
Catalysed by UROC1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:13101CC BY 4.0Reference data

Other names

2 names

Resolves to: UROC1

Also called: Imidazolonepropionate hydrolaseUrocanase

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