Proteins/UNIPROT:Q9H3U1

UNC45A

ProteinUNIPROT:Q9H3U1

Acts as a co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity)..

Function from UniProtKB (Q9H3U1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

osteootohepatoenteric syndrome has a germline basis in UNC45ADiseaseGenCC HGNC:30594|MONDO:0859164Inferred only

Statements

18 statements

18 statements · 1 reference database · Subject: UNC45A · Sources: Hetionet

Order

ISYNA1 covaries with UNC45AProteinHetionet hetionet:covaries:51477-55898Inferred only
LRFN2 covaries with UNC45AProteinHetionet hetionet:covaries:55898-57497Inferred only
UNC45A covaries with MXRA8ProteinHetionet hetionet:covaries:54587-55898Inferred only
ZIC1 covaries with UNC45AProteinHetionet hetionet:covaries:55898-7545Inferred only
SMAD9 interacts with UNC45AProteinHetionet hetionet:interacts:4093-55898Inferred only
ATP1B1 increases the expression of UNC45AProteinHetionet hetionet:regulates:481-55898Inferred only
CD58 increases the expression of UNC45AProteinHetionet hetionet:regulates:965-55898Inferred only
CXCL12 increases the expression of UNC45AProteinHetionet hetionet:regulates:6387-55898Inferred only
FAH decreases the expression of UNC45AProteinHetionet hetionet:regulates:2184-55898Inferred only
GMPS increases the expression of UNC45AProteinHetionet hetionet:regulates:8833-55898Inferred only
GSTZ1 increases the expression of UNC45AProteinHetionet hetionet:regulates:2954-55898Inferred only
MSH6 increases the expression of UNC45AProteinHetionet hetionet:regulates:2956-55898Inferred only

Show the remaining 6

NFE2L2 increases the expression of UNC45AProteinHetionet hetionet:regulates:4780-55898Inferred only
PSMD3 increases the expression of UNC45AProteinHetionet hetionet:regulates:5709-55898Inferred only
RPIA increases the expression of UNC45AProteinHetionet hetionet:regulates:22934-55898Inferred only
STAMBP increases the expression of UNC45AProteinHetionet hetionet:regulates:10617-55898Inferred only
TGFBR1 increases the expression of UNC45AProteinHetionet hetionet:regulates:7046-55898Inferred only
ZMIZ1 increases the expression of UNC45AProteinHetionet hetionet:regulates:57178-55898Inferred only

Other names

5 names

Resolves to: UNC45A

Also called: GCUNC-45SMAP-1SMAP1Smooth muscle cell-associated protein 1Unc-45A

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