Proteins/UNIPROT:Q14CS0

UBXN2B

ProteinUNIPROT:Q14CS0

Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis..

Function from UniProtKB (Q14CS0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 2 reference databases · Subject: UBXN2B · Sources: gene ontology, Hetionet

Order

UBC interacts with UBXN2BProteinHetionet hetionet:interacts:137886-7316Inferred only
UBXN2B regulates negative regulation of protein localization to centrosomeBiological processgene ontology Q14CS0|GO:1904780Inferred only
UBXN2B regulates positive regulation of mitotic centrosome separationBiological processgene ontology Q14CS0|GO:0046604Inferred only
CAMK2G increases the expression of UBXN2BProteinHetionet hetionet:regulates:818-137886Inferred only
ESR2 increases the expression of UBXN2BProteinHetionet hetionet:regulates:2100-137886Inferred only
FBXO11 decreases the expression of UBXN2BProteinHetionet hetionet:regulates:80204-137886Inferred only
HDAC1 decreases the expression of UBXN2BProteinHetionet hetionet:regulates:3065-137886Inferred only
LZIC increases the expression of UBXN2BProteinHetionet hetionet:regulates:84328-137886Inferred only
MGST2 increases the expression of UBXN2BProteinHetionet hetionet:regulates:4258-137886Inferred only
NCOR2 increases the expression of UBXN2BProteinHetionet hetionet:regulates:9612-137886Inferred only
PFDN2 increases the expression of UBXN2BProteinHetionet hetionet:regulates:5202-137886Inferred only
PPP2R3A increases the expression of UBXN2BProteinHetionet hetionet:regulates:5523-137886Inferred only

Show the remaining 4

RPN1 increases the expression of UBXN2BProteinHetionet hetionet:regulates:6184-137886Inferred only
RUVBL2 increases the expression of UBXN2BProteinHetionet hetionet:regulates:10856-137886Inferred only
SDHA increases the expression of UBXN2BProteinHetionet hetionet:regulates:6389-137886Inferred only
SMAD4 increases the expression of UBXN2BProteinHetionet hetionet:regulates:4089-137886Inferred only

Other names

2 names

Resolves to: UBXN2B

Also called: NSFL1 cofactor p37p97 cofactor p37

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