Proteins/UNIPROT:Q53H54

TYW2

ProteinUNIPROT:Q53H54tRNA wybutosine-synthesizing protein 2 homolog

S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86..

Function from UniProtKB (Q53H54), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 3 reference databases · Subject: TYW2 · Sources: Hetionet, Reactome, Rhea

Order

TYW2 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
TYW2 participates in Synthesis of wybutosine at G37 of tRNA(Phe)PathwayReactome R-HSA-6782861Inferred only
TYW2 participates in tRNA modification in the nucleus and cytosolPathwayReactome R-HSA-6782315Inferred only
TYW2 participates in tRNA processingPathwayReactome R-HSA-72306Inferred only
IL4R increases the expression of TYW2ProteinHetionet hetionet:regulates:3566-55039Inferred only
PSAP increases the expression of TYW2ProteinHetionet hetionet:regulates:5660-55039Inferred only
TLE1 increases the expression of TYW2ProteinHetionet hetionet:regulates:7088-55039Inferred only
S-methyl-5'-thioadenosine is a substrate of TYW2CompoundRhea RHEA:36355Inferred only

Reactions

1 reaction

4-demethylwyosine(37) in tRNA(Phe)+S-adenosyl-L-methionine4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe)+S-methyl-5'-thioadenosine+hydron
Catalysed by TYW2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:36355CC BY 4.0Reference data

Other names

4 names

Resolves to: TYW2

Also called: TRM12TRMT12tRNA-yW-synthesizing protein 2tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase

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