Proteins/UNIPROT:Q9GZX9

TWSG1

ProteinUNIPROT:Q9GZX9

May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity)..

Function from UniProtKB (Q9GZX9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 3 reference databases · Subject: TWSG1 · Sources: gene ontology, Hetionet, WikiPathways

Order

BMP4 interacts with TWSG1ProteinHetionet hetionet:interacts:57045-652Inferred only
CHRD interacts with TWSG1ProteinHetionet hetionet:interacts:57045-8646Inferred only
TWSG1 participates in Mesodermal commitment pathwayPathwayWikiPathways WP2857Inferred only
TWSG1 regulates negative regulation of CD4-positive, alpha-beta T cell activationBiological processgene ontology Q9GZX9|GO:2000515Inferred only
TWSG1 regulates negative regulation of CD4-positive, alpha-beta T cell proliferationBiological processgene ontology Q9GZX9|GO:2000562Inferred only
TWSG1 regulates negative regulation of cytokine productionBiological processgene ontology Q9GZX9|GO:0001818Inferred only
TWSG1 regulates positive regulation of SMAD protein signal transductionBiological processgene ontology Q9GZX9|GO:0060391Inferred only
TWSG1 regulates positive regulation of transforming growth factor beta receptor signaling pathwayBiological processgene ontology Q9GZX9|GO:0030511Inferred only
TWSG1 regulates regulation of BMP signaling pathwayBiological processgene ontology Q9GZX9|GO:0030510Inferred only
DUSP3 increases the expression of TWSG1ProteinHetionet hetionet:regulates:1845-57045Inferred only
ELP1 decreases the expression of TWSG1ProteinHetionet hetionet:regulates:8518-57045Inferred only
FANCL decreases the expression of TWSG1ProteinHetionet hetionet:regulates:55120-57045Inferred only

Show the remaining 4

NENF decreases the expression of TWSG1ProteinHetionet hetionet:regulates:29937-57045Inferred only
TOMM34 decreases the expression of TWSG1ProteinHetionet hetionet:regulates:10953-57045Inferred only
TRIM13 decreases the expression of TWSG1ProteinHetionet hetionet:regulates:10206-57045Inferred only
ZFX decreases the expression of TWSG1ProteinHetionet hetionet:regulates:7543-57045Inferred only

Other names

2 names

Resolves to: TWSG1

Also called: TSGTwisted gastrulation protein homolog 1

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