Proteins/UNIPROT:Q6SA08

TSSK4

ProteinUNIPROT:Q6SA08

Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells. Phosphorylates CREM on 'Ser-116' in vitro (By similarity). Phosphorylates ODF2 on 'Ser-95' (By similarity)..

Function from UniProtKB (Q6SA08), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

9 statements

9 statements · 3 reference databases · Subject: TSSK4 · Sources: Hetionet, UniProt, WikiPathways

Order

OR8I2 covaries with TSSK4ProteinHetionet hetionet:covaries:120586-283629Inferred only
CREB1 interacts with TSSK4ProteinHetionet hetionet:interacts:1385-283629Inferred only
SMURF2 interacts with TSSK4ProteinHetionet hetionet:interacts:283629-64750Inferred only
TGFBR1 interacts with TSSK4ProteinHetionet hetionet:interacts:283629-7046Inferred only
TSSK4 participates in Male infertilityPathwayWikiPathways WP4673Inferred only
TSSK4 increases the expression of DHRS2ProteinHetionet hetionet:regulates:283629-10202Inferred only
TSSK4 decreases the expression of PRCPProteinHetionet hetionet:regulates:283629-5547Inferred only
TSSK4 decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:283629-6192Inferred only
TSSK4 requires the cofactor magnesium(2+)CompoundUniProt Q6SA08Inferred only

Reactions

2 reactions

L-seryl-[protein]+ATP(4-)O-phospho-L-seryl-[protein]+ADP(3-)+hydron
Catalysed by SGK1 or CDC7 or PLK4 or STK25 or CIT or RIOK3 or MAP2K7 or CHEK1 or BCKDK or IKBKB or CASK or AURKA and 347 more alternatives
Reaction pageLeft to right

Other names

8 names

Resolves to: TSSK4

Also called: 22EC14orf20Serine/threonine-protein kinase 22ESTK22ETestis-specific kinase 4TSK-4TSSK-4TSSK5

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