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Proteins/UNIPROT:O75648
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base..
Function from UniProtKB (O75648), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
7 statements
7 statements · 4 reference databases · Subject: TRMU · Sources: Bgee, Hetionet, Reactome, Rhea
2 reactions
proton+CHEBI:16680+MAM03059cS-adenosyl-L-methionine+MAM03058c
Catalysed by TRMU
Reaction pageReversibleBalance undeterminableEC 2.8.1.-cytosol
Human-GEM MAR09521CC BY 4.0Reference data
5-taurinomethyluridine(34) in tRNA+S-sulfanyl-L-cysteinyl-[protein]+AH2+ATP(4-)5-taurinomethyl-2-thiouridine(34) in tRNA+L-cysteinyl-[protein]+A+
3 names
Resolves to: TRMU
Catalysed by TRMU
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47040CC BY 4.0Reference data